Differentially passive circuits that switch and oscillate

The concept of passivity is central to analyze circuits as interconnections of passive components. We illustrate that when used differentially, the same concept leads to an interconnection theory for electrical circuits that switch and oscillate as interconnections of passive components with operational amplifiers (op-amps). The approach builds on recent results on dominance and p-passivity aimed at generalizing dissipativity theory to the analysis of non-equilibrium nonlinear systems. Our paper shows how those results apply to basic and well-known nonlinear circuit architectures. They illustrate the potential of dissipativity theory to design and analyze switching and oscillating circuits quantitatively, very much like their linear counterparts

Design of a low-voltage op-amp-less ASDM to linearise VCO-ADC

A very simple asynchronous sigma delta modulator design for linearisation of VCO ADC's is presented. The circuit only consists of a passive feedback filter and a Schmitt Trigger. By proper sizing, the non-linearity error can be reduced to well below 0.12% for input signals that go almost rail-to-rail. The design has been manufactured in the low power version of TSMC 65 nm technology and was measured at a 1 V power supply

A Fully Differential Phase-Locked Loop With Reduced Loop Bandwidth Variation

Phase-Locked Loops (PLLs) are essential building blocks to wireless communications as they are responsible for implementing the frequency synthesizer within a wireless transceiver. In order to maintain the rapid pace of development thus far seen in wireless technology, the PLL must develop accordingly to meet the increasingly demanding requirements imposed on it by today's (and tomorrows) wireless devices. Specically this entails meeting stringent noise specications imposed by modern wireless standards, meeting low power consumption budgets to prolong battery lifetimes, operating under reduced supply voltages imposed by modern technology nodes and within the noisy environments of complex system-on-chip (SOC) designs, all in addition to consuming as little silicon area as possible. The ability of the PLL to achieve the above is thus key to its continual progress in enabling wireless technology achieve increasingly powerful products which increasingly benet our daily lives. This thesis furthers the development of PLLs with respect to meeting the challenges imposed upon it by modern wireless technology, in two ways. Firstly, the thesis describes in detail the advantages to be gained through employing a fully dierential PLL. Specically, such PLLs are shown to achieve low noise performance, consume less silicon area than their conventional counterparts whilst consuming similar power, and being better suited to the low supply voltages imposed by continual technology downsizing. Secondly, the thesis proposes a sub-banded VCO architecture which, in addition to satisfying simultaneous requirements for large tuning ranges and low phase noise, achieves signicant reductions in PLL loop bandwidth variation. First and foremost, this improves on the stability of the PLL in addition to improving its dynamic locking behaviour whilst oering further improvements in overall noise performance. Since the proposed sub-banded architecture requires no additional power over a conventional sub-banded architecture, the solution thus remains attractive to the realm of low power design. These two developments combine to form a fully dierential PLL with reduced loop bandwidth variation. As such, the resulting PLL is well suited to meeting the increasingly demanding requirements imposed on it by today's (and tomorrows) wireless devices, and thus applicable to the continual development of wireless technology in benetting our daily lives

Expression of renal distal tubule transporters TRPM6 and NCC in a rat model of cyclosporine nephrotoxicity and effect of EGF treatment

Renal magnesium (Mg(2+)) and sodium (Na(+)) loss are well-known side effects of cyclosporine (CsA) treatment in humans, but the underlying mechanisms still remain unclear. Recently, it was shown that epidermal growth factor (EGF) stimulates Mg(2+) reabsorption in the distal convoluted tubule (DCT) via TRPM6 (Thebault S, Alexander RT, Tiel Groenestege WM, Hoenderop JG, Bindels RJ. J Am Soc Nephrol 20: 78-85, 2009). In the DCT, the final adjustment of renal sodium excretion is regulated by the thiazide-sensitive Na(+)-Cl(-) cotransporter (NCC), which is activated by the renin-angiotensin-aldosterone system (RAAS). The aim of this study was to gain more insight into the molecular mechanisms of CsA-induced hypomagnesemia and hyponatremia. Therefore, the renal expression of TRPM6, TRPM7, EGF, EGF receptor, claudin-16, claudin-19, and the NCC, and the effect of the RAAS on NCC expression, were analyzed in vivo in a rat model of CsA nephrotoxicity. Also, the effect of EGF administration on these parameters was studied. CsA significantly decreased the renal expression of TRPM6, TRPM7, NCC, and EGF, but not that of claudin-16 and claudin-19. Serum aldosterone was significantly lower in CsA-treated rats. In control rats treated with EGF, an increased renal expression of TRPM6 together with a decreased fractional excretion of Mg(2+) (FE Mg(2+)) was demonstrated. EGF did not show this beneficial effect on TRPM6 and FE Mg(2+) in CsA-treated rats. These data suggest that CsA treatment affects Mg(2+) homeostasis via the downregulation of TRPM6 in the DCT. Furthermore, CsA downregulates the NCC in the DCT, associated with an inactivation of the RAAS, resulting in renal sodium loss

Analysis and Design of a 1.8-GHz CMOS LC Quadrature VCO

This paper presents a quadrature voltage-controlled oscillator (QVCO) based on the coupling of two LC-tank VCOs. A simplified theoretical analysis for the oscillation frequency and phase noise displayed by the QVCO in the 1/f/sup 3/ region is developed, and good agreement is found between theory and simulation results. A prototype for the QVCO was implemented in a 0.35-/spl mu/m CMOS process with three standard metal layers. The QVCO could be tuned between 1.64 and 1.97 GHz, and showed a phase noise of -140 dBc/Hz or less across the tuning range at a 3-MHz offset frequency from the carrier, for a current consumption of 25 mA from a 2-V power supply. The equivalent phase error between I and Q signals was at most 0.25/spl deg/

Insights into Parkinson’s disease from computational models of the basal ganglia

Movement disorders arise from the complex interplay of multiple changes to neural circuits. Successful treatments for these disorders could interact with these complex changes in myriad ways, and as a consequence their mechanisms of action and their amelioration of symptoms are incompletely understood. Using Parkinson's disease as a case study, we review here how computational models are a crucial tool for taming this complexity, across causative mechanisms, consequent neural dynamics and treatments. For mechanisms, we review models that capture the effects of losing dopamine on basal ganglia function; for dynamics, we discuss models that have transformed our understanding of how beta-band (15-30?Hz) oscillations arise in the parkinsonian basal ganglia. For treatments, we touch on the breadth of computational modelling work trying to understand the therapeutic actions of deep brain stimulation. Collectively, models from across all levels of description are providing a compelling account of the causes, symptoms and treatments for Parkinson's disease