Involvement of the cortico-basal ganglia-thalamocortical loop in developmental stuttering

Stuttering is a complex neurodevelopmental disorder that has to date eluded a clear explication of its pathophysiological bases. In this review, we utilize the Directions Into Velocities of Articulators (DIVA) neurocomputational modeling framework to mechanistically interpret relevant findings from the behavioral and neurological literatures on stuttering. Within this theoretical framework, we propose that the primary impairment underlying stuttering behavior is malfunction in the cortico-basal ganglia-thalamocortical (hereafter, cortico-BG) loop that is responsible for initiating speech motor programs. This theoretical perspective predicts three possible loci of impaired neural processing within the cortico-BG loop that could lead to stuttering behaviors: impairment within the basal ganglia proper; impairment of axonal projections between cerebral cortex, basal ganglia, and thalamus; and impairment in cortical processing. These theoretical perspectives are presented in detail, followed by a review of empirical data that make reference to these three possibilities. We also highlight any differences that are present in the literature based on examining adults versus children, which give important insights into potential core deficits associated with stuttering versus compensatory changes that occur in the brain as a result of having stuttered for many years in the case of adults who stutter. We conclude with outstanding questions in the field and promising areas for future studies that have the potential to further advance mechanistic understanding of neural deficits underlying persistent developmental stuttering.R01 DC007683 - NIDCD NIH HHS; R01 DC011277 - NIDCD NIH HHSPublished versio

Spoken word classification in children and adults

Purpose: Preschool children often have difficulties in word classification, despite good speech perception and production. Some researchers suggest they represent words using phonetic features rather than phonemes. We examine whether there is a progression from feature based to phoneme based processing across age groups, and whether responses are consistent across tasks and stimuli. Method: In Study 1, 120 3 to 5 year old children completed three tasks assessing use of phonetic features in classification, with an additional 58 older children completing one of the three tasks. In Study 2, all of the children, together with an additional adult sample, completed a nonword learning task. Results: In all four tasks, children classified words sharing phonemes as similar. In addition, children regarded words as similar if they shared manner of articulation, particularly word-finally. Adults also showed this sensitivity to manner, but across the tasks there was a pattern of increasing use of phonemic information with age. Conclusions: Children tend to classify words as similar if they share phonemes or share manner of articulation word finally. Use of phonemic information becomes more common with age. These findings are in line with the theory that phonological representations become more detailed in the preschool years

Children at risk : their phonemic awareness development in holistic instruction

Includes bibliographical references (p. 17-19

Study of Touch Gesture Performance by Four and Five Year-Old Children: Point-and-Touch, Drag-and-Drop, Zoom-in and Zoom-out, and Rotate

Past research has focused on children\u27s interaction with computers through mouse clicks, and mouse research studies focused on point-and-click and drag-and-drop. However, More research is necessary in regard to children\u27s ability to perform touch gestures such as point-and-touch, drag-and-drop, zoom-in and zoom-out, and rotate. Furthermore, research should consider specific gestures such as zoom-in and zoom-out, and rotate tasks for young children. The aim of this thesis is to study the ability of 4 and 5 year-old children to interact with touch devices and perform tasks such as: point-and-touch, drag-and-drop, zoom-in and zoom-out, and rotate. This thesis tests an iPad application with four experiments on 17 four and five-year-old children, 16 without motor impairment and 1 with a motor impairment disability. The results show that 5-year-old children perform better than 4-year-old children in the four experiments. Results indicate that interaction design for young children that uses Point-and-Touch gestures should consider distance between targets, and designs using Drag-and-Drop gestures should consider size of targets, as these have significant effects in the way children perform these gestures. Also, designers should consider size and rotation direction in rotate tasks, as it is smoother for young children to rotate clockwise objects. The result of the four different touch gestures tasks shows that time was not an important factor in children\u27s performance

From early markers to neuro-developmental mechanisms of autism

A fast growing field, the study of infants at risk because of having an older sibling with autism (i.e. infant sibs) aims to identify the earliest signs of this disorder, which would allow for earlier diagnosis and intervention. More importantly, we argue, these studies offer the opportunity to validate existing neuro-developmental models of autism against experimental evidence. Although autism is mainly seen as a disorder of social interaction and communication, emerging early markers do not exclusively reflect impairments of the “social brain”. Evidence for atypical development of sensory and attentional systems highlight the need to move away from localized deficits to models suggesting brain-wide involvement in autism pathology. We discuss the implications infant sibs findings have for future work into the biology of autism and the development of interventions

Speech planning as an index of speech motor control maturity

International audienceThis paper investigates speech motor control maturity in 4-year-old Canadian French children. Acoustic and ultrasound data recorded from four children, and for comparison, from four adults, are presented and analyzed. Maturity of speech motor control is assessed by measuring two characteristics: token-to-token variability of isolated vowels, as a measure of motor control accuracy, and extra-syllabic anticipatory coarticulation within V1-C-V2 sequences. In line with theories of optimal motor control, anticipatory coarticulation is assumed to be based on the use of internal models of the speech apparatus and its efficiency is considered to reflect the maturity of these representations. In agreement with former studies, token-to-token variability is larger in children than in adults. An anticipation of V2 in V1 was found in all adults but in none of the children studied so far. These results indicate that children's speech motor control is immature from two perspectives: insufficiently accurate motor control patterns for vowel production, and inability to anticipate forthcoming gestures. Both aspects are discussed and interpreted in the context of the immaturity of the internal representations of the speech motor apparatus in 4-year-old children