8,957 research outputs found
Visual Spike-based Convolution Processing with a Cellular Automata Architecture
this paper presents a first approach for
implementations which fuse the Address-Event-Representation
(AER) processing with the Cellular Automata using FPGA and
AER-tools. This new strategy applies spike-based convolution
filters inspired by Cellular Automata for AER vision
processing. Spike-based systems are neuro-inspired circuits
implementations traditionally used for sensory systems or
sensor signal processing. AER is a neuromorphic
communication protocol for transferring asynchronous events
between VLSI spike-based chips. These neuro-inspired
implementations allow developing complex, multilayer,
multichip neuromorphic systems and have been used to design
sensor chips, such as retinas and cochlea, processing chips, e.g.
filters, and learning chips. Furthermore, Cellular Automata is a
bio-inspired processing model for problem solving. This
approach divides the processing synchronous cells which
change their states at the same time in order to get the solution.Ministerio de Educación y Ciencia TEC2006-11730-C03-02Ministerio de Ciencia e Innovación TEC2009-10639-C04-02Junta de Andalucía P06-TIC-0141
The Kinetic Basis of Self-Organized Pattern Formation
In his seminal paper on morphogenesis (1952), Alan Turing demonstrated that
different spatio-temporal patterns can arise due to instability of the
homogeneous state in reaction-diffusion systems, but at least two species are
necessary to produce even the simplest stationary patterns. This paper is aimed
to propose a novel model of the analog (continuous state) kinetic automaton and
to show that stationary and dynamic patterns can arise in one-component
networks of kinetic automata. Possible applicability of kinetic networks to
modeling of real-world phenomena is also discussed.Comment: 8 pages, submitted to the 14th International Conference on the
Synthesis and Simulation of Living Systems (Alife 14) on 23.03.2014, accepted
09.05.201
The barrel cortex—integrating molecular, cellular and systems physiology
A challenge for neurobiology is to integrate information across many levels of research, ranging from behaviour and neuronal networks to cells and molecules. The rodent whisker signalling pathway to the primary somatosensory neocortex with its remarkable somatotopic barrel map is emerging as a key system for such integrative studie
Nanodiamonds-induced effects on neuronal firing of mouse hippocampal microcircuits
Fluorescent nanodiamonds (FND) are carbon-based nanomaterials that can
efficiently incorporate optically active photoluminescent centers such as the
nitrogen-vacancy complex, thus making them promising candidates as optical
biolabels and drug-delivery agents. FNDs exhibit bright fluorescence without
photobleaching combined with high uptake rate and low cytotoxicity. Focusing on
FNDs interference with neuronal function, here we examined their effect on
cultured hippocampal neurons, monitoring the whole network development as well
as the electrophysiological properties of single neurons. We observed that FNDs
drastically decreased the frequency of inhibitory (from 1.81 Hz to 0.86 Hz) and
excitatory (from 1.61 Hz to 0.68 Hz) miniature postsynaptic currents, and
consistently reduced action potential (AP) firing frequency (by 36%), as
measured by microelectrode arrays. On the contrary, bursts synchronization was
preserved, as well as the amplitude of spontaneous inhibitory and excitatory
events. Current-clamp recordings revealed that the ratio of neurons responding
with AP trains of high-frequency (fast-spiking) versus neurons responding with
trains of low-frequency (slow-spiking) was unaltered, suggesting that FNDs
exerted a comparable action on neuronal subpopulations. At the single cell
level, rapid onset of the somatic AP ("kink") was drastically reduced in
FND-treated neurons, suggesting a reduced contribution of axonal and dendritic
components while preserving neuronal excitability.Comment: 34 pages, 9 figure
Surface functionalisation of nanodiamonds for human neural stem cell adhesion and proliferation.
Biological systems interact with nanostructured materials on a sub-cellular level. These interactions may govern cell behaviour and the precise control of a nanomaterial's structure and surface chemistry allow for a high degree of tunability to be achieved. Cells are surrounded by an extra-cellular matrix with nano-topographical properties. Diamond based materials, and specifically nanostructured diamond has attracted much attention due to its extreme electrical and mechanical properties, chemical inertness and biocompatibility. Here the interaction of nanodiamond monolayers with human Neural Stem Cells (hNSCs) has been investigated. The effect of altering surface functionalisation of nanodiamonds on hNSC adhesion and proliferation has shown that confluent cellular attachment occurs on oxygen terminated nanodiamonds (O-NDs), but not on hydrogen terminated nanodiamonds (H-NDs). Analysis of H and O-NDs by Atomic Force Microscopy, contact angle measurements and protein adsorption suggests that differences in topography, wettability, surface charge and protein adsorption of these surfaces may underlie the difference in cellular adhesion of hNSCs reported here
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