Automated Diagnostic System for Grading of Diabetic Retinopathy Stages from Fundus Images Using Texture Features

Computational methodologies and medical imaging are become an important part of real time applications. These techniques transform medicine by providing effective health care diagnosis in all major disease areas. This will allow the clinicians to understand life-saving information using less invasive techniques. Diabetes is a rapidly increasing worldwide disease that occurs when the body is unable to metabolize glucose. It increases the risk of a range of eye diseases, but the main cause of blindness associated with diabetes is Diabetic retinopathy (DR). A new feature based automated technique for diagnosis and grading of normal, Nonproliferative diabetic retinopathy (NPDR) and Proliferative diabetic retinopathy (PDR) is proposed in this paper. This method involves preprocessing of retinal images, detection of lesions, extraction of blood vessels and extraction of texture features such as local binary pattern, Laws texture energy and Fractal Dimension. These features were used for classification of DR stages by means of supervised classifiers namely Support vector machine (SVM) and Extreme Learning Machine (ELM). In this work, in addition to morphological features, statistically significant texture features were also used for classification. It was found that the average classification accuracy of 98.88%, sensitivity and specificity of 100% respectively achieved using ELM classifier with texture features. The results were validated by comparing with expert ophthalmologists. This proposed automated diagnostic system reduces the work of professionals during mass screening of DR stages

Automatic Classification of Bright Retinal Lesions via Deep Network Features

The diabetic retinopathy is timely diagonalized through color eye fundus images by experienced ophthalmologists, in order to recognize potential retinal features and identify early-blindness cases. In this paper, it is proposed to extract deep features from the last fully-connected layer of, four different, pre-trained convolutional neural networks. These features are then feeded into a non-linear classifier to discriminate three-class diabetic cases, i.e., normal, exudates, and drusen. Averaged across 1113 color retinal images collected from six publicly available annotated datasets, the deep features approach perform better than the classical bag-of-words approach. The proposed approaches have an average accuracy between 91.23% and 92.00% with more than 13% improvement over the traditional state of art methods.Comment: Preprint submitted to Journal of Medical Imaging | SPIE (Tue, Jul 28, 2017

Automatic Segmentation of Exudates in Ocular Images using Ensembles of Aperture Filters and Logistic Regression

Hard and soft exudates are the main signs of diabetic macular edema (DME). The segmentation of both kinds of exudates generates valuable information not only for the diagnosis of DME, but also for treatment, which helps to avoid vision loss and blindness. In this paper, we propose a new algorithm for the automatic segmentation of exudates in ocular fundus images. The proposed algorithm is based on ensembles of aperture filters that detect exudate candidates and remove major blood vessels from the processed images. Then, logistic regression is used to classify each candidate as either exudate or non-exudate based on a vector of 31 features that characterize each potensial lesion. Finally, we tested the performance of the proposed algorithm using the images in the public HEI-MED database.Fil: Benalcazar Palacios, Marco Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Secretaría Nacional de Educación Superior, Ciencia, Tecnología e Innovación; EcuadorFil: Brun, Marcel. Universidad Nacional de Mar del Plata; ArgentinaFil: Ballarin, Virginia Laura. Universidad Nacional de Mar del Plata; Argentin

An Ensemble Classifier Based on Individual Features for Detecting Microaneurysms in Diabetic Retinopathy

Individuals with diabetes are more likely to develop Diabetic Retinopathy (DR), a chronic ailment that can lead to blindness if left undiagnosed. Early-stage Diabetic Retinopathy (DR) is characterized by Microaneurysms (MA), which appear as tiny red lesions on the retina. This paper investigates a unique approach for the automated early identification of microaneurysms  in eye images. A unique ensemble classifier technique is suggested in this work. Classifiers like SVM, KNN, Decision Tree, and Naïve Bayes are chosen in this study for building an ensemble model. After preprocessing the image, certain common image characteristics such as shape and intensity features were retrieved from the candidate. The mean absolute difference of each feature is computed. Based on mean ranges that would give improved classification results, an expert classifier is chosen and trained. The outputs of the classifiers are integrated for each of the distinct characteristics, and the number of categories that have been most frequently repeated is utilized to reach a final decision. The process has been comprehensively validated using two available open datasets, like e-ophtha and DIARETDB1. On the e-ophtha and DIARETDB1 datasets, the ensemble model achieved an AUC of 0.928 and 0.873, Sensitivity of 90.7% and 85%, Specificity of 90% and 91% respectively

Detection of Early Signs of Diabetic Retinopathy Based on Textural and Morphological Information in Fundus Images

[EN] Estimated blind people in the world will exceed 40 million by 2025. To develop novel algorithms based on fundus image descriptors that allow the automatic classification of retinal tissue into healthy and pathological in early stages is necessary. In this paper, we focus on one of the most common pathologies in the current society: diabetic retinopathy. The proposed method avoids the necessity of lesion segmentation or candidate map generation before the classification stage. Local binary patterns and granulometric profiles are locally computed to extract texture and morphological information from retinal images. Different combinations of this information feed classification algorithms to optimally discriminate bright and dark lesions from healthy tissues. Through several experiments, the ability of the proposed system to identify diabetic retinopathy signs is validated using different public databases with a large degree of variability and without image exclusion.This work has been partially supported by the Spanish Ministry of Economy and Competitiveness through project DPI2016-77869 and GVA through project PROMETEO/2019/109Colomer, A.; Igual García, J.; Naranjo Ornedo, V. (2020). Detection of Early Signs of Diabetic Retinopathy Based on Textural and Morphological Information in Fundus Images. Sensors. 20(4):1-20. https://doi.org/10.3390/s20041005S120204World Report on Vision. Technical Report, 2019https://www.who.int/publications-detail/world-report-on-visionFong, D. S., Aiello, L., Gardner, T. W., King, G. L., Blankenship, G., Cavallerano, J. D., … Klein, R. (2003). Retinopathy in Diabetes. Diabetes Care, 27(Supplement 1), S84-S87. doi:10.2337/diacare.27.2007.s84COGAN, D. G. (1961). Retinal Vascular Patterns. 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