Alzheimers Disease Diagnosis by Deep Learning Using MRI-Based Approaches

The most frequent kind of dementia of the nervous system, Alzheimer's disease, weakens several brain processes (such as memory) and eventually results in death. The clinical study uses magnetic resonance imaging to diagnose AD. Deep learning algorithms are capable of pattern recognition and feature extraction from the inputted raw data. As early diagnosis and stage detection are the most crucial elements in enhancing patient care and treatment outcomes, deep learning algorithms for MRI images have recently allowed for diagnosing a medical condition at the beginning stage and identifying particular symptoms of Alzheimer's disease. As a result, we aimed to analyze five specific studies focused on AD diagnosis using MRI-based deep learning algorithms between 2021 and 2023 in this study. To completely illustrate the differences between these techniques and comprehend how deep learning algorithms function, we attempted to explore selected approaches in depth

Diagnosis and monitoring of Alzheimer's patients using classical and deep learning techniques

Machine based analysis and prediction systems are widely used for diagnosis of Alzheimer's Disease (AD). However, lower accuracy of existing techniques and lack of post diagnosis monitoring systems limit the scope of such studies. In this paper, a novel machine learning based diagnosis and monitoring of AD-like diseases is proposed. The AD-like diseases diagnosis process is accomplished by analysing the magnetic resonance imaging (MRI) scans using deep learning and is followed by an activity monitoring framework to monitor the subjects’ activities of daily living using body worn inertial sensors. The activity monitoring provides an assistive framework in daily life activities and evaluates vulnerability of the patients based on the activity level. The AD diagnosis results show up to 82% improvement in comparison to well-known existing techniques. Moreover, above 95% accuracy is achieved to classify the activities of daily living which is quite encouraging in terms of monitoring the activity profile of the subject

Diagnosis and monitoring of Alzheimer's patients using classical and deep learning techniques

Machine based analysis and prediction systems are widely used for diagnosis of Alzheimer's Disease (AD). However, lower accuracy of existing techniques and lack of post diagnosis monitoring systems limit the scope of such studies. In this paper, a novel machine learning based diagnosis and monitoring of AD-like diseases is proposed. The AD-like diseases diagnosis process is accomplished by analysing the magnetic resonance imaging (MRI) scans using deep learning and is followed by an activity monitoring framework to monitor the subjects’ activities of daily living using body worn inertial sensors. The activity monitoring provides an assistive framework in daily life activities and evaluates vulnerability of the patients based on the activity level. The AD diagnosis results show up to 82% improvement in comparison to well-known existing techniques. Moreover, above 95% accuracy is achieved to classify the activities of daily living which is quite encouraging in terms of monitoring the activity profile of the subject

Detection of Alzheimer's disease onset using MRI and PET neuroimaging: Longitudinal data analysis and machine learning

The scientists are dedicated to studying the detection of Alzheimer’s disease onset to find a cure, or at the very least, medication that can slow the progression of the disease. This article explores the effectiveness of longitudinal data analysis, artificial intelligence, and machine learning approaches based on magnetic resonance imaging and positron emission tomography neuroimaging modalities for progression estimation and the detection of Alzheimer’s disease onset. The significance of feature extraction in highly complex neuroimaging data, identification of vulnerable brain regions, and the determination of the threshold values for plaques, tangles, and neurodegeneration of these regions will extensively be evaluated. Developing automated methods to improve the aforementioned research areas would enable specialists to determine the progression of the disease and find the link between the biomarkers and more accurate detection of Alzheimer’s disease onset

A Machine Learning Classification Framework for Early Prediction of Alzheimer’s Disease

People today, in addition to their concerns about getting old and having to go through watching themselves grow weak and wrinkly, are facing an increasing fear of dementia. There are around 47 million people affected by dementia worldwide and the cost associated with providing them health and social care support is estimated to reach 2 trillion by 2030 which is almost equivalent to the 18th largest economy in the world. The most common form of dementia with the highest costs in health and social care is Alzheimer’s disease, which gradually kills neurons and causes patients to lose loving memories, the ability to recognise family members, childhood memories, and even the ability to follow simple instructions. Alzheimer’s disease is irreversible, unstoppable and has no known cure. Besides being a calamity to affected patients, it is a great financial burden on health providers. Health care providers also face a challenge in diagnosing the disease as current methods used to diagnose Alzheimer’s disease rely on manual evaluations of a patient’s medical history and mental examinations such as the Mini-Mental State Examination. These diagnostic methods often give a false diagnosis and were designed to identify Alzheimer’s after stage two when the part of all symptoms are evident. The problem is that clinicians are unable to stop or control the progress of Alzheimer’s disease, because of a lack of knowledge on the patterns that triggered the development of the disease. In this thesis, we explored and investigated Alzheimer’s disease from a computational perspective to uncover different risk factors and present a strategic framework called Early Prediction of Alzheimer’s Disease Framework (EPADf) that would give a future prediction of early-onset Alzheimer’s disease. Following extensive background research that resulted in the formalisation of the framework concept, prediction approaches, and the concept of ranking the risk factors based on clinical instinct, knowledge and experience using mathematical reasoning, we carried out experiments to get further insight and investigate the disease further using machine learning models. In this study, we used machine learning models and conducted two classification experiments for early prediction of Alzheimer’s disease, and one ranking experiment to rank its risk factors by importance. Besides these experiments, we also presented two logical approaches to search for patterns in an Alzheimer’s dataset, and a ranking algorithm to rank Alzheimer’s disease risk factors based on clinical evaluation. For the classification experiments we used five different Machine Learning models; Random Forest (RF), Random Oracle Model (ROM), a hybrid model combined of Levenberg-Marquardt neural network and Random Forest, combined using Fischer discriminate analysis (H2), Linear Neural Networks (LNN), and Multi-layer Perceptron Model (MLP). These models were deployed on a de-identified multivariable patient’s data, provided by the ADNI (Alzheimer’s disease Neuroimaging Initiative), to illustrate the effective use of data analysis to investigate Alzheimer’s disease biological and behavioural risk factors. We found that the continues enhancement of patient’s data and the use of combined machine learning models can provide an early cost-effective prediction of Alzheimer’s disease, and help in extracting insightful information on the risk factors of the disease. Based on this work and findings we have developed the strategic framework (EPADf) which is discussed in more depth in this thesis

Computer-Aided Diagnoses (CAD) System: An Artificial Neural Network Approach to MRI Analysis and Diagnosis of Alzheimer’s Disease (AD)

Alzheimer’s disease (AD) is a chronic and progressive, irreversible syndrome that deteriorates the cognitive functions. Official death certificates of 2013 reported 84,767 deaths from Alzheimer’s disease, making it the 6th leading cause of death in the United States. The rate of AD is estimated to double by 2050. The neurodegeneration of AD occurs decades before symptoms of dementia are evident. Therefore, having an efficient methodology for the early and proper diagnosis can lead to more effective treatments. Neuroimaging techniques such as magnetic resonance imaging (MRI) can detect changes in the brain of living subjects. Moreover, medical imaging techniques are the best diagnostic tools to determine brain atrophies; however, a significant limitation is the level of training, methodology, and experience of the diagnostician. Thus, Computer aided diagnosis (CAD) systems are part of a promising tool to help improve the diagnostic outcomes. No publications addressing the use of Feedforward Artificial Neural Networks (ANN), and MRI image attributes for the classification of AD were found. Consequently, the focus of this study is to investigate if the use of MRI images, specifically texture and frequency attributes along with a feedforward ANN model, can lead to the classification of individuals with AD. Moreover, this study compared the use of a single view versus a multi-view of MRI images and their performance. The frequency, texture, and MRI views in combination with the feedforward artificial neural network were tested to determine if they were comparable to the clinician’s performance. The clinician’s performances used were 78 percent accuracy, 87 percent sensitivity, 71 percent specificity, and 78 percent precision from a study with 1,073 individuals. The study found that the use of the Discrete Wavelet Transform (DWT) and Fourier Transform (FT) low frequency give comparable results to the clinicians; however, the FT outperformed the clinicians with an accuracy of 85 percent, precision of 87 percent, sensitivity of 90 percent and specificity of 75 percent. In the case of texture, a single texture feature, and the combination of two or more features gave results comparable to the clinicians. However, the Gray level co-occurrence matrix (GLCOM), which is the combination of texture features, was the highest performing texture method with 82 percent accuracy, 86 percent sensitivity, 76 percent specificity, and 86 percent precision. Combination CII (energy and entropy) outperformed all other combinations with 78 percent accuracy, 88 percent sensitivity, 72 percent specificity, and 78 percent precision. Additionally, a combination of views can increase performance for certain texture attributes; however, the axial view outperformed the sagittal and coronal views in the case of frequency attributes. In conclusion, this study found that both texture and frequency characteristics in combinations with a feedforward backpropagation neural network can perform at the level of the clinician and even higher depending on the attribute and the view or combination of views used

The presymptomatic treatment with 3HFWC nanosubstance decreased plaque load in 5XFAD mouse model of Alzheimer's disease

Introduction In the present study, we assessed the effects of the hyper-harmonized-hydroxylated fullerene–water complex (3HFWC) on Alzheimer's disease (AD) neuropathological hallmarks in 5XFAD mice, an AD animal model. Methods The 3-week-old 5XFAD mice were exposed to 3HFWC water solution ad libitum for 3 months in the presymptomatic phase of pathology. The functional effects of the treatment were confirmed through near-infrared spectroscopy (NIRS) analysis through machine learning (ML) using artificial neural networks (ANNs) to classify the control and 3HFWC-treated brain tissue samples. The effects of 3HFWC treatment on amyloid-β (Aβ) accumulation, plaque formation, gliosis, and synaptic plasticity in cortical and hippocampal tissue were assessed. Results The 3HFWC treatment significantly decreased the amyloid-β plaque load in specific parts of the cerebral cortex. At the same time, 3HFWC treatment did not induce the activation of glia (astrocytes and microglia) nor did it negatively affect synaptic protein markers (GAP-43, synaptophysin, and PSD-95). Conclusion The obtained results point to the potential of 3HFWC, when applied in the presymptomatic phase of AD, to interfere with amyloid plaque formation without inducing AD-related pathological processes such as neuroinflammation, gliosis, and synaptic vulnerability

Multi-modal feature selection with self-expression topological manifold for end-stage renal disease associated with mild cognitive impairment

Effectively selecting discriminative brain regions in multi-modal neuroimages is one of the effective means to reveal the neuropathological mechanism of end-stage renal disease associated with mild cognitive impairment (ESRDaMCI). Existing multi-modal feature selection methods usually depend on the Euclidean distance to measure the similarity between data, which tends to ignore the implied data manifold. A self-expression topological manifold based multi-modal feature selection method (SETMFS) is proposed to address this issue employing self-expression topological manifold. First, a dynamic brain functional network is established using functional magnetic resonance imaging (fMRI), after which the betweenness centrality is extracted. The feature matrix of fMRI is constructed based on this centrality measure. Second, the feature matrix of arterial spin labeling (ASL) is constructed by extracting the cerebral blood flow (CBF). Then, the topological relationship matrices are constructed by calculating the topological relationship between each data point in the two feature matrices to measure the intrinsic similarity between the features, respectively. Subsequently, the graph regularization is utilized to embed the self-expression model into topological manifold learning to identify the linear self-expression of the features. Finally, the selected well-represented feature vectors are fed into a multicore support vector machine (MKSVM) for classification. The experimental results show that the classification performance of SETMFS is significantly superior to several state-of-the-art feature selection methods, especially its classification accuracy reaches 86.10%, which is at least 4.34% higher than other comparable methods. This method fully considers the topological correlation between the multi-modal features and provides a reference for ESRDaMCI auxiliary diagnosis

Automated Segmentation And Classification Technique For Brain Stroke

Difussion-Weighted Imaging (DWI) plays an important role in the diagnosis of brain stroke by providing detailed information regarding the soft tissue contrast in the brain organ. Conventionally, the differential diagnosis of brain stroke lesions is performed manually by professional neuroradiologists during a highly subjective and time- consuming process. This study proposes a segmentation and classification technique to detect brain stroke lesions based on diffusion-weighted imaging (DWI). The type of stroke lesions consists of acute ischemic, sub-acute ischemic, chronic ischemic and acute hemorrhage. For segmentation, fuzzy c-Means (FCM) and active contour is proposed to segment the lesion’s region. FCM is implemented with active contour to separate the cerebral spinal fluid (CSF) with the hypointense lesion. Pre-processing is applied to the DWI for image normalization, background removal and image enhancement. The algorithm performance has been evaluated using Jaccard Index, Dice Coefficient (DC) and both false positive rate (FPR) and false negative rate (FNR). The average results for the Jaccard index, DC, FPR and FNR are 0.55, 0.68, 0.23 and 0.23, respectively. First statistical order method is applied to the segmentation result to obtain the features for the classifier input. For classification technique, bagged tree classifier is proposed to classify the type of stroke. The accuracy results for the classification is 90.8%. Based on the results, the proposed technique has potential to segment and classify brain stroke lesion from DWI image