12,603 research outputs found
Mobile Glaucoma Detection Application
Glaucoma is a debilitating optical degeneration disease that can lead to vision loss and eventually blindness. Given its asymptomatic nature, most people with Glaucoma aren’t even aware that they have the disease. As a result, the disease is often left untreated until it is too late. Detecting the presence of Glaucoma is one of the most important steps in treating Glaucoma, but is unfortunately also the most difficult to enforce. The Mobile Glaucoma Detection application aims to reduce the growing number of individuals who are unaware that they have Glaucoma by providing a simple detection mechanism to notify users if they are at risk. The system does this by enabling its users to independently conduct Tonometry exams through the application. Tonometry examinations allow doctors to determine if the intra-ocular pressure levels in a person’s eyes put them at risk for Glaucoma. The M.G.D.A(Mobile Glaucoma Detection Application) allows users to determine their intra-ocular pressure levels from the comfort of their own home via a special contact lens paired with a smartphone application. The system also offers users the opportunity to monitor, regulate, and track their use and progress through the system
A flexible integrative approach based on random forest improves prediction of transcription factor binding sites
Transcription factor binding sites (TFBSs) are DNA sequences of 6-15 base pairs. Interaction of these TFBSs with transcription factors (TFs) is largely responsible for most spatiotemporal gene expression patterns. Here, we evaluate to what extent sequence-based prediction of TFBSs can be improved by taking into account the positional dependencies of nucleotides (NPDs) and the nucleotide sequence-dependent structure of DNA. We make use of the random forest algorithm to flexibly exploit both types of information. Results in this study show that both the structural method and the NPD method can be valuable for the prediction of TFBSs. Moreover, their predictive values seem to be complementary, even to the widely used position weight matrix (PWM) method. This led us to combine all three methods. Results obtained for five eukaryotic TFs with different DNA-binding domains show that our method improves classification accuracy for all five eukaryotic TFs compared with other approaches. Additionally, we contrast the results of seven smaller prokaryotic sets with high-quality data and show that with the use of high-quality data we can significantly improve prediction performance. Models developed in this study can be of great use for gaining insight into the mechanisms of TF binding
Consistent distribution-free -sample and independence tests for univariate random variables
A popular approach for testing if two univariate random variables are
statistically independent consists of partitioning the sample space into bins,
and evaluating a test statistic on the binned data. The partition size matters,
and the optimal partition size is data dependent. While for detecting simple
relationships coarse partitions may be best, for detecting complex
relationships a great gain in power can be achieved by considering finer
partitions. We suggest novel consistent distribution-free tests that are based
on summation or maximization aggregation of scores over all partitions of a
fixed size. We show that our test statistics based on summation can serve as
good estimators of the mutual information. Moreover, we suggest regularized
tests that aggregate over all partition sizes, and prove those are consistent
too. We provide polynomial-time algorithms, which are critical for computing
the suggested test statistics efficiently. We show that the power of the
regularized tests is excellent compared to existing tests, and almost as
powerful as the tests based on the optimal (yet unknown in practice) partition
size, in simulations as well as on a real data example.Comment: arXiv admin note: substantial text overlap with arXiv:1308.155
Models for Paired Comparison Data: A Review with Emphasis on Dependent Data
Thurstonian and Bradley-Terry models are the most commonly applied models in
the analysis of paired comparison data. Since their introduction, numerous
developments have been proposed in different areas. This paper provides an
updated overview of these extensions, including how to account for object- and
subject-specific covariates and how to deal with ordinal paired comparison
data. Special emphasis is given to models for dependent comparisons. Although
these models are more realistic, their use is complicated by numerical
difficulties. We therefore concentrate on implementation issues. In particular,
a pairwise likelihood approach is explored for models for dependent paired
comparison data, and a simulation study is carried out to compare the
performance of maximum pairwise likelihood with other limited information
estimation methods. The methodology is illustrated throughout using a real data
set about university paired comparisons performed by students.Comment: Published in at http://dx.doi.org/10.1214/12-STS396 the Statistical
Science (http://www.imstat.org/sts/) by the Institute of Mathematical
Statistics (http://www.imstat.org
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