An Efficient Machine Learning Approach for Prediction of Conjunctiva Hyperemia Assessment using Feature Extraction Methods

The human eye is one of the most intricate sense organs. It is crucial to protect your eyes against several eye disorders that can cause vision loss if untreated in order to maintain your ability to see well. Early detection of eye diseases is therefore crucial in order to prevent any unintended consequences and control the diseases continued progression. Conjunctivitis is one such eye condition that is characterized by conjunctival inflammation, resulting in symptoms like hyperemia (redness) due to increased blood flow. With the aid of the best treatments, modern techniques, and early, precise diagnosis by professionals, it can be cured or can be greatly reduced. The proper diagnosis of the underlying cause of visual problems is frequently postponed or never carried out because of  shortage of diagnostic experts, which leads to either insufficient or postponed corrective treatment. In order to diagnose and evaluate conjunctivitis, segmentation methods are essential for locating and measuring hyperemic regions. In the present study, segmentation techniques are applied along  with feature extraction techniques to provide an effective machine learning framework for the prediction of eye problems. Using the discrete cosine transform (DCT), the segmented regions of interest are converted into feature vectors. These feature vectors are then used to train machine learning classifiers, including random forest and neural networks, which achieve a promising accuracy of 95.92%. This approach enables ophthalmologists to make more objective and accurate assessments, aiding in disease severity evaluation

Intraocular Lens

The first clinical application of intraocular lens (IOL) goes back to 1949 when Dr. Harold Ridley successfully implanted a PMMA IOL into an eye on 29 November 1949. This innovation is a big step forward for cataract surgery. With development of the IOL material and biocompatibility, more and more IOL types have been used in clinical ophthalmology. This book is the fruit of worldwide cooperation between clinical teams. In this book we discuss the IOL materials and design, aberration and astigmatism correction with IOL, entopic phenomenon of IOL, myopia and phakic IOL, and secondary IOL techniques. We believe that this content provides the readers with a comprehensive knowledge of the latest developments of IOL

Lipid Based Frameworks And Topical Ocular Inserts For The Delivery Of Small Molecule Therapeutics To The Posterior Segment Of The Eye

Lipid based systems and topical ocular inserts of various drugs were developed for the intervention/treatment of posterior segment ocular complications. Indomethacin (IN) was developed into solid lipid nanoparticles (SLNs) and Nanostructured lipid carriers (NLCs). Effect of surface functionalization using chitosan (CS) on lipid nanocarriers was tested to evaluate corneal penetration. Surface modification of SLNs with CS increased ocular penetration of IN. NLCs maintained significantly higher IN concentrations in all ocular tissues tested, compared to the other formulations evaluated in vivo. Effect of surface poly (ethylene) glycol (PEG) functionalization of the NLCs on ocular disposition was studied using Ciprofloxacin (CIP) as a model drug. Transcorneal penetration of CIP from NLCs was optimum with PEG molecular weight in between 2K to 10K. In vivo ocular tissue CIP concentrations attained from the various formulations was consistent with the in vitro data obtained. Feasibility of melt-cast, topical, ocular inserts for delivery of drugs, with different physicochemical properties, to the posterior segment of the eye was studied. The model drugs tested include indomethacin (IN), ciprofloxacin hydrochloride (CIP) and prednisolone sodium phosphate (PSP). Transmembrane flux of IN, PSP and CIP were enhanced by ~3.5-folds, ~3.6-folds and ~2.9-folds, respectively, from the polymeric inserts when compared to the control formulations, post 3 h. Moreover, ocular inserts generated significantly higher drug levels in all the ocular tissues, including the retina-choroid, when compared to their control formulations. Cationic lipid nanoparticles of Natamycin (NT) were also evaluated. NT SLNs were compared with NT marketed formulation – 5% w/v ophthalmic suspension - in terms of transcorneal permeation and in vivo ocular tissue distribution. Compared to Natacyn® control, transcorneal permeability of NT was enhanced ~ 3-folds with the CLBN formulation. In vivo studies demonstrated that CLBN, at a 50-fold lower dose, was as effective as the control formulation in terms of NT delivery to the retinal tissues. Resveratrol (RES), a multi-faceted candidate was formulated into SLNs. Transcorneal flux of RES was increased ~ 1.5-folds with the SLN formulation, when compared to control formulation. The results from the all the above studies demonstrated that lipid based systems and melt-cast topical ocular inserts serve as viable platforms in the niche of ocular delivery

Macular Edema: The Current Recommendations for Clinical Practice

The book contains nine articles on the subject of diagnosis and treatment of macular edema due to different causes. It presents both reviews of current recommendations of macular edema treatment as well as original research on specific forms of that entity

Ocular complications of herpes zoster ophthalmicus

Fifty percent of patients with ophthalmic zoster develop ocular complications. These may be mild or severe, and can lead to loss of sight which, by timely and good management can be prevented in most cases. Unfortunately knowledge of the complications and their management is often poor making the design and interpretation of clinical trials difficult. 1356 cases of ophthalmic zoster were collected over fifteen years with at least 6 months follow up. Their details and complications were entered into a database. There is a generally held impression that patients developing zoster do so because of impaired immunity. Analysis of our findings showed that this was not so. The database results were analyzed to quantify the incidence of complications and their correlates. Two common corneal complications that are difficult to manage and lead to visual impairment were studied in detail including: Mucous plaque keratitis is defined as a distinct entity appearing at an early or late stage and occurred in forty seven cases. Poor management leads to visual impairment from neurotrophic ulceration, megaplaque keratitis and glaucoma. Lipid keratopathy induces diminished visual acuity and photophobia. It occurred in thirty six cases. Careful and prolonged treatment of chronic stromal keratitis with topical steroid will prevent this occurring, but when it does successful laser occlusion of corneal blood vessels halts the deposition of lipid and may actually disperse it or make the host cornea safer for keratoplasty. One hundred and seventy six patients were screened orthoptically and the incidence of extraocular muscle palsies assessed with regard to distribution and natural history. Possible pathogeneses are discussed. Overall recovery was good. Lastly iritis and iris atrophy were identified in five hundred and twenty patients and twenty three were investigated with anterior segment fluorescein angiography. This showed that they were associated with an ischaemic vasculitis

Updates on Myopia

This book is open access under a CC BY 4.0 license. This open access book discusses basic clinical concepts of myopia, prevention of progression and surgical treatments for myopia and pathological myopia. It also summarises the latest evidence and best practices for managing myopia, high myopia and its complications. Written by leading experts, the book addresses clinical diagnosis and interpretation of imaging modalities, and various complications of myopia such as glaucoma, choroidal neovascularization, retinal degeneration and cataracts. It is a valuable comprehensive resource for general and sub-specialist ophthalmologists as well as residents and ophthalmologists in training.

Development of a therapeutic trans-sclera illuminated laser delivery device for retinal pathologies

Master'sMASTER OF SCIENC

Contact lens platforms for ocular health monitoring

As of today, the World Health Organization (WHO) counts millions of cases of preventable blindness every year in high income countries, attributed to the lack of early-stage ophthalmic screening technologies. Contemporary methods rely on bulky and costly equipment exclusively operated by specialized clinicians, resulting in a medical approach based on reaction over prevention. A possible approach results from a literature survey on the tear fluid properties, which revealed its potential to be used as a diagnostic medium. However, existing tear sampling technologies lack practicality, and introduce a high contamination risk of tear samples

Proceedings of the Third International Symposium on Retinopathy of Prematurity: An update on ROP from the lab to the nursery (November 2003, Anaheim, California)

The Third International Symposium on Retinopathy of Prematurity (ROP) was convened with the aim of cross fertilizing the horizons of basic and clinical scientists with an interest in the pathogenesis and management of infants with ROP. Ten speakers in the clinical sciences and ten speakers in the basic sciences were recruited on the basis of their research to provide state of the art talks. The meeting was held November 9, 2003 immediately prior to the American Academy of Ophthalmology meeting; scholarships were provided for outreach to developing countries and young investigators. This review contain the summaries of the 20 platform presentations prepared by the authors and the abstracts of presented posters. Each author was asked to encapsulate the current state of understanding, identify areas of controversy, and make recommendations for future research. The basic science presentations included insights into the development of the human retinal vasculature, animal models for ROP, growth factors that affect normal development and ROP, and promising new therapeutic approaches to treating ROP like VEGF targeting, inhibition of proteases, stem cells, ribozymes to silence genes, and gene therapy to deliver antiangiogenic agents. The clinical presentations included new insights into oxygen management, updates on the CRYO-ROP and ETROP studies, visual function in childhood following ROP, the neural retina in ROP, screening for ROP, management of stage 3 and 4 ROP, ROP in the third world, and the complications of ROP in adult life. The meeting resulted in a penetrating exchange between clinicians and basic scientists, which provided great insights for conference attendees. The effect of preterm delivery on the normal cross-talk of neuroretinal and retinal vascular development is a fertile ground for discovering new understanding of the processes involved both in normal development and in retinal neovascular disorders. The meeting also suggested promising potential therapeutic interventions on the horizon for ROP

Advances in Ophthalmology

This book focuses on the different aspects of ophthalmology - the medical science of diagnosis and treatment of eye disorders. Ophthalmology is divided into various clinical subspecialties, such as cornea, cataract, glaucoma, uveitis, retina, neuro-ophthalmology, pediatric ophthalmology, oncology, pathology, and oculoplastics. This book incorporates new developments as well as future perspectives in ophthalmology and is a balanced product between covering a wide range of diseases and expedited publication. It is intended to be the appetizer for other books to follow. Ophthalmologists, researchers, specialists, trainees, and general practitioners with an interest in ophthalmology will find this book interesting and useful