Neuromorphic Neuromodulation: Towards the next generation of on-device AI-revolution in electroceuticals

Neuromodulation techniques have emerged as promising approaches for treating a wide range of neurological disorders, precisely delivering electrical stimulation to modulate abnormal neuronal activity. While leveraging the unique capabilities of artificial intelligence (AI) holds immense potential for responsive neurostimulation, it appears as an extremely challenging proposition where real-time (low-latency) processing, low power consumption, and heat constraints are limiting factors. The use of sophisticated AI-driven models for personalized neurostimulation depends on back-telemetry of data to external systems (e.g. cloud-based medical mesosystems and ecosystems). While this can be a solution, integrating continuous learning within implantable neuromodulation devices for several applications, such as seizure prediction in epilepsy, is an open question. We believe neuromorphic architectures hold an outstanding potential to open new avenues for sophisticated on-chip analysis of neural signals and AI-driven personalized treatments. With more than three orders of magnitude reduction in the total data required for data processing and feature extraction, the high power- and memory-efficiency of neuromorphic computing to hardware-firmware co-design can be considered as the solution-in-the-making to resource-constraint implantable neuromodulation systems. This could lead to a new breed of closed-loop responsive and personalised feedback, which we describe as Neuromorphic Neuromodulation. This can empower precise and adaptive modulation strategies by integrating neuromorphic AI as tightly as possible to the site of the sensors and stimulators. This paper presents a perspective on the potential of Neuromorphic Neuromodulation, emphasizing its capacity to revolutionize implantable brain-machine microsystems and significantly improve patient-specificity.Comment: 17 page

Power Efficient Data Compression Hardware for Wearable and Wireless Biomedical Sensing Devices

This thesis aims to verify a possible benefit lossless data compression and reduction techniques can bring to a wearable and wireless biomedical device, which is anticipated to be system power saving. A wireless transceiver is one of the main contributors to the system power of a wireless biomedical sensing device, and reducing the data transmitted by the transceiver with a minimum hardware cost can therefore help to save the power. This thesis is going to investigate the impact of the data compression and reduction on the system power of a wearable and wireless biomedical device and trying to find a proper compression technique that can achieve power saving of the device. The thesis first examines some widely used lossy and lossless data compression and reduction techniques for biomedical data, especially EEG data. Then it introduces a novel lossless biomedical data compression technique designed for this research called Log2 sub-band encoding. The thesis then moves on to the biomedical data compression evaluation of the Log2 sub-band encoding and an existing 2-stage technique consisting of the DPCM and the Huffman encoding. The next part of this thesis explores the signal classification potential of the Log2 sub-band encoding. It was found that some of the signal features extracted as a by-product during the Log2 sub-band encoding process could be used to detect certain signal events like epileptic seizures, with a proper method. The final section of the thesis focuses on the power analysis of the hardware implementation of two compression techniques referred to earlier, as well as the system power analysis. The results show that the Log2 sub-band is comparable and even superior to the 2-stage technique in terms of data compression and power performance. The system power requirement of an EEG signal recorder that has the Log2 sub-band implemented is significantly reduced

The rise of flexible electronics in neuroscience, from materials selection to in vitro and in vivo applications

Neuroscience deals with one of the most complicate system we can study: the brain. The huge amount of connections among the cells and the different phenomena occurring at different scale give rise to a continuous flow of data that have to be collected, analyzed and interpreted. Neuroscientists try to interrogate this complexity to find basic principles underlying brain electrochemical signalling and human/animal behaviour to disclose the mechanisms that trigger neurodegenerative diseases and to understand how restoring damaged brain circuits. The main tool to perform these tasks is a neural interface, a system able to interact with brain tissue at different levels to provide a uni/bidirectional communication path. Recently, breakthroughs coming from various disciplines have been combined to enforce features and potentialities of neural interfaces. Among the different findings, flexible electronics is playing a pivotal role in revolutionizing neural interfaces. In this work, we review the most recent advances in the fabrication of neural interfaces based on flexible electronics. We define challenges and issues to be solved for the application of such platforms and we discuss the different parts of the system regarding improvements in materials selection and breakthrough in applications both for in vitro and in vivo tests

Compressive Sensing with Low-Power Transfer and Accurate Reconstruction of EEG Signals

Tele-monitoring of EEG in WBAN is essential as EEG is the most powerful physiological parameters to diagnose any neurological disorder. Generally, EEG signal needs to record for longer periods which results in a large volume of data leading to huge storage and communication bandwidth requirements in WBAN. Moreover, WBAN sensor nodes are battery operated which consumes lots of energy. The aim of this research is, therefore, low power transmission of EEG signal over WBAN and its accurate reconstruction at the receiver to enable continuous online-monitoring of EEG and real time feedback to the patients from the medical experts. To reduce data rate and consequently reduce power consumption, compressive sensing (CS) may be employed prior to transmission. Nonetheless, for EEG signals, the accuracy of reconstruction of the signal with CS depends on a suitable dictionary in which the signal is sparse. As the EEG signal is not sparse in either time or frequency domain, identifying an appropriate dictionary is paramount. There are a plethora of choices for the dictionary to be used. Wavelet bases are of interest due to the availability of associated systems and methods. However, the attributes of wavelet bases that can lead to good quality of reconstruction are not well understood. For the first time in this study, it is demonstrated that in selecting wavelet dictionaries, the incoherence with the sensing matrix and the number of vanishing moments of the dictionary should be considered at the same time. In this research, a framework is proposed for the selection of an appropriate wavelet dictionary for EEG signal which is used in tandem with sparse binary matrix (SBM) as the sensing matrix and ST-SBL method as the reconstruction algorithm. Beylkin (highly incoherent with SBM and relatively high number of vanishing moments) is identified as the best dictionary to be used amongst the dictionaries are evaluated in this thesis. The power requirements for the proposed framework are also quantified using a power model. The outcomes will assist to realize the computational complexity and online implementation requirements of CS for transmitting EEG in WBAN. The proposed approach facilitates the energy savings budget well into the microwatts range, ensuring a significant savings of battery life and overall system’s power. The study is intended to create a strong base for the use of EEG in the high-accuracy and low-power based biomedical applications in WBAN

Improving the mechanistic study of neuromuscular diseases through the development of a fully wireless and implantable recording device

Neuromuscular diseases manifest by a handful of known phenotypes affecting the peripheral nerves, skeletal muscle fibers, and neuromuscular junction. Common signs of these diseases include demyelination, myasthenia, atrophy, and aberrant muscle activity—all of which may be tracked over time using one or more electrophysiological markers. Mice, which are the predominant mammalian model for most human diseases, have been used to study congenital neuromuscular diseases for decades. However, our understanding of the mechanisms underlying these pathologies is still incomplete. This is in part due to the lack of instrumentation available to easily collect longitudinal, in vivo electrophysiological activity from mice. There remains a need for a fully wireless, batteryless, and implantable recording system that can be adapted for a variety of electrophysiological measurements and also enable long-term, continuous data collection in very small animals. To meet this need a miniature, chronically implantable device has been developed that is capable of wirelessly coupling energy from electromagnetic fields while implanted within a body. This device can both record and trigger bioelectric events and may be chronically implanted in rodents as small as mice. This grants investigators the ability to continuously observe electrophysiological changes corresponding to disease progression in a single, freely behaving, untethered animal. The fully wireless closed-loop system is an adaptable solution for a range of long-term mechanistic and diagnostic studies in rodent disease models. Its high level of functionality, adjustable parameters, accessible building blocks, reprogrammable firmware, and modular electrode interface offer flexibility that is distinctive among fully implantable recording or stimulating devices. The key significance of this work is that it has generated novel instrumentation in the form of a fully implantable bioelectric recording device having a much higher level of functionality than any other fully wireless system available for mouse work. This has incidentally led to contributions in the areas of wireless power transfer and neural interfaces for upper-limb prosthesis control. Herein the solution space for wireless power transfer is examined including a close inspection of far-field power transfer to implanted bioelectric sensors. Methods of design and characterization for the iterative development of the device are detailed. Furthermore, its performance and utility in remote bioelectric sensing applications is demonstrated with humans, rats, healthy mice, and mouse models for degenerative neuromuscular and motoneuron diseases

Neurotechnology : design of a semi-dry electroencephalography electrode

In the research of the brain, the most complex organ of the human body, its function can be studied through the analysis of Evoked Potentials (EP). This evoked activity can be reproduced in a diverse way and recorded with an Electroencephalogram (EEG). To register the different types of brainwaves, the electrodes have a very important role. The first part of the thesis presents an extended literature review of the different types of EEG electrodes available on the market, out-standing publications and patents. A semi-dry porous ceramic electrode prototype was proposed to register EEG signals. The sensor model was developed with the aim of improving the accuracy of the actual sensors, checking many current designs, and improving artefact attenuation. It was not possible to test this design for lack of time and resources. Additionally, an EEG headset was also studied and developed to place the in-built-reservoir sensors according to the 10-20 placement system. Moreover, on the second part of this project, a skin-electrode contact impedance protocol was presented and tested with four different dry electrode materials in a diverse frequency range. The protocol used, which is a combination of some techniques already employed, has differentiated and separated the potential external hazards that can provoke an impact on bioimpedance measurements. The results obtained allow to determine the degree of utility of an electrode and how much time was required and recommended to place the electrodes before its optimal impedance acquisition.Outgoin

Wireless system for the measurement of bioelectric signals using capacitive electrodes

Català: Aquest projecte mostra el disseny i la implementació d'un sistema d'adquisició de senyals bioelèctriques mitjançant elèctrodes capacitius. El sistema, inalàmbric i a bateria, envia les dades a un ordinador per a la seva visualització o processament.Castellano: Este proyecto muestra el diseño y la implementación de un sistema de adquisición de señales bioeléctricas mediante electrodos capacitivos. El sistema, inalámbrico y a batería, envía los datos a un ordenador para su visualización o procesamiento.English: This project shows the design and implementation of an acquisition system for the measurement of bioelectric signals by means of capacitive electrodes. The system, which is wireless and battery powered, sends the data to a computer for its visualizations or processing