Process of designing robust, dependable, safe and secure software for medical devices: Point of care testing device as a case study

This article has been made available through the Brunel Open Access Publishing Fund.Copyright © 2013 Sivanesan Tulasidas et al. This paper presents a holistic methodology for the design of medical device software, which encompasses of a new way of eliciting requirements, system design process, security design guideline, cloud architecture design, combinatorial testing process and agile project management. The paper uses point of care diagnostics as a case study where the software and hardware must be robust, reliable to provide accurate diagnosis of diseases. As software and software intensive systems are becoming increasingly complex, the impact of failures can lead to significant property damage, or damage to the environment. Within the medical diagnostic device software domain such failures can result in misdiagnosis leading to clinical complications and in some cases death. Software faults can arise due to the interaction among the software, the hardware, third party software and the operating environment. Unanticipated environmental changes and latent coding errors lead to operation faults despite of the fact that usually a significant effort has been expended in the design, verification and validation of the software system. It is becoming increasingly more apparent that one needs to adopt different approaches, which will guarantee that a complex software system meets all safety, security, and reliability requirements, in addition to complying with standards such as IEC 62304. There are many initiatives taken to develop safety and security critical systems, at different development phases and in different contexts, ranging from infrastructure design to device design. Different approaches are implemented to design error free software for safety critical systems. By adopting the strategies and processes presented in this paper one can overcome the challenges in developing error free software for medical devices (or safety critical systems).Brunel Open Access Publishing Fund

Enhanced Parallel Generation of Tree Structures for the Recognition of 3D Images

Segmentations of a digital object based on a connectivity criterion at n-xel or sub-n-xel level are useful tools in image topological analysis and recognition. Working with cell complex analogous of digital objects, an example of this kind of segmentation is that obtained from the combinatorial representation so called Homological Spanning Forest (HSF, for short) which, informally, classifies the cells of the complex as belonging to regions containing the maximal number of cells sharing the same homological (algebraic homology with coefficient in a field) information. We design here a parallel method for computing a HSF (using homology with coefficients in Z/2Z) of a 3D digital object. If this object is included in a 3D image of m1 × m2 × m3 voxels, its theoretical time complexity order is near O(log(m1 + m2 + m3)), under the assumption that a processing element is available for each voxel. A prototype implementation validating our results has been written and several synthetic, random and medical tridimensional images have been used for testing. The experiments allow us to assert that the number of iterations in which the homological information is found varies only to a small extent from the theoretical computational time.Ministerio de Economía y Competitividad MTM2016-81030-

Fuzzy Adaptive Tuning of a Particle Swarm Optimization Algorithm for Variable-Strength Combinatorial Test Suite Generation

Combinatorial interaction testing is an important software testing technique that has seen lots of recent interest. It can reduce the number of test cases needed by considering interactions between combinations of input parameters. Empirical evidence shows that it effectively detects faults, in particular, for highly configurable software systems. In real-world software testing, the input variables may vary in how strongly they interact, variable strength combinatorial interaction testing (VS-CIT) can exploit this for higher effectiveness. The generation of variable strength test suites is a non-deterministic polynomial-time (NP) hard computational problem \cite{BestounKamalFuzzy2017}. Research has shown that stochastic population-based algorithms such as particle swarm optimization (PSO) can be efficient compared to alternatives for VS-CIT problems. Nevertheless, they require detailed control for the exploitation and exploration trade-off to avoid premature convergence (i.e. being trapped in local optima) as well as to enhance the solution diversity. Here, we present a new variant of PSO based on Mamdani fuzzy inference system \cite{Camastra2015,TSAKIRIDIS2017257,KHOSRAVANIAN2016280}, to permit adaptive selection of its global and local search operations. We detail the design of this combined algorithm and evaluate it through experiments on multiple synthetic and benchmark problems. We conclude that fuzzy adaptive selection of global and local search operations is, at least, feasible as it performs only second-best to a discrete variant of PSO, called DPSO. Concerning obtaining the best mean test suite size, the fuzzy adaptation even outperforms DPSO occasionally. We discuss the reasons behind this performance and outline relevant areas of future work.Comment: 21 page

A Fast and Accurate Cost Model for FPGA Design Space Exploration in HPC Applications

Heterogeneous High-Performance Computing (HPC) platforms present a significant programming challenge, especially because the key users of HPC resources are scientists, not parallel programmers. We contend that compiler technology has to evolve to automatically create the best program variant by transforming a given original program. We have developed a novel methodology based on type transformations for generating correct-by-construction design variants, and an associated light-weight cost model for evaluating these variants for implementation on FPGAs. In this paper we present a key enabler of our approach, the cost model. We discuss how we are able to quickly derive accurate estimates of performance and resource-utilization from the design’s representation in our intermediate language. We show results confirming the accuracy of our cost model by testing it on three different scientific kernels. We conclude with a case-study that compares a solution generated by our framework with one from a conventional high-level synthesis tool, showing better performance and power-efficiency using our cost model based approach