Incremental simulation modelling for Internet collaborative design

In order to support Web-based collaborative design in terms of transferring or updating models dynamically and efficiently, new incremental modelling and local updating strategies have been developed for simulation modelling application since simulation is more focused on visualisation effects than on geometry details. Based on an assembly connection concept, a drag-and-drop assembly method has also been proposed in simulation assembly. An assembly connection is defined as a group of assembly constraints and it makes assembly easier. A case study example is given to show the content of the proposed research

Prototype system for supporting the incremental modelling of vague geometric configurations

In this paper the need for Intelligent Computer Aided Design (Int.CAD) to jointly support design and learning assistance is introduced. The paper focuses on presenting and exploring the possibility of realizing learning assistance in Int.CAD by introducing a new concept called Shared Learning. Shared Learning is proposed to empower CAD tools with more useful learning capabilities than that currently available and thereby provide a stronger interaction of learning between a designer and a computer. Controlled computational learning is proposed as a means whereby the Shared Learning concept can be realized. The viability of this new concept is explored by using a system called PERSPECT. PERSPECT is a preliminary numerical design tool aimed at supporting the effective utilization of numerical experiential knowledge in design. After a detailed discussion of PERSPECT's numerical design support, the paper presents the results of an evaluation that focuses on PERSPECT's implementation of controlled computational learning and ability to support a designer's need to learn. The paper then discusses PERSPECT's potential as a tool for supporting the Shared Learning concept by explaining how a designer and PERSPECT can jointly learn. There is still much work to be done before the full potential of Shared Learning can be realized. However, the authors do believe that the concept of Shared Learning may hold the key to truly empowering learning in Int.CAD

Research for the mechanical behavior of simple-supported irregular reinforced concrete slab bridge

Reinforced concrete slab bridges are of excellent integrity, small beam hight and flexible structure. In order to adapt to the topographic condition ，road alignment and traffic function in practical engineering, the superstructure of slab bridge is usually designed as irregular shaped structure. Irregular slab bridges, as a kind of typical space structures, are always in multiaxial stress state and display complex mechanical behavior. So, precise analysis theory and practical simplified calculating method are necessary to be improved. In this paper, a simple-supported irregular bridge, Wayaoxi Bridge, located in Tuokou town, Guizhou Province, is taken as background project. The irregular slab bridge of Wayaoxi is simulated by three numerical finite element models, namely，shell model, solid model and space beam grillage model. Furthermore, test of bridge in-site is carried out. By comparing the results of numerical calculation and bridge test, mechanical behavior and dynamic characteristic of the irregular slab bridge under highway design load can be obtained. Applicable conditions have been presented through the analysis of computational accuracy of each finite element modal. Finally, the conclusions of this research can be applied to the calculation, design and construction of this type of irregular slab structures

Mathematical and computer modeling of electro-optic systems using a generic modeling approach

The conventional approach to modelling electro-optic sensor systems is to develop separate models for individual systems or classes of system, depending on the detector technology employed in the sensor and the application. However, this ignores commonality in design and in components of these systems. A generic approach is presented for modelling a variety of sensor systems operating in the infrared waveband that also allows systems to be modelled with different levels of detail and at different stages of the product lifecycle. The provision of different model types (parametric and image-flow descriptions) within the generic framework can allow valuable insights to be gained

What thermodynamic features characterize good and bad folders? Results from a simplified off-lattice protein model

The thermodynamics of the small SH3 protein domain is studied by means of a simplified model where each bead-like amino acid interacts with the others through a contact potential controlled by a 20x20 random matrix. Good folding sequences, characterized by a low native energy, display three main thermodynamical phases, namely a coil-like phase, an unfolded globule and a folded phase (plus other two phases, namely frozen and random coil, populated only at extremes temperatures). Interestingly, the unfolded globule has some regions already structured. Poorly designed sequences, on the other hand, display a wide transition from the random coil to a frozen state. The comparison with the analytic theory of heteropolymers is discussed

Experiments and simulations on short chain fatty acid production in a colonic bacterial community

Understanding how production of specific metabolites by gut microbes is modulated by interactions with surrounding species and by environmental nutrient availability is an important open challenge in microbiome research. As part of this endeavor, we explore interactions between F. prausnitzii, a major butyrate producer, and B. thetaiotaomicron, an acetate producer, under three different in vitro media conditions in monoculture and coculture. In silico Genome-scale dynamic flux balance analysis (dFBA) models of metabolism in the system using COMETS (Computation of Microbial Ecosystems in Time and Space) are also tested for explanatory, predictive and inferential power. Experimental findings indicate enhancement of butyrate production in coculture relative to F. prausnitzii monoculture but defy a simple model of monotonic increases in butyrate production as a function of acetate availability in the medium. Simulations recapitulate biomass production curves for monocultures and accurately predict the growth curve of coculture total biomass, using parameters learned from monocultures, suggesting that the model captures some aspects of how the two bacteria interact. However, a comparison of data and simulations for environmental acetate and butyrate changes suggest that the organisms adopt one of many possible metabolic strategies equivalent in terms of growth efficiency. Furthermore, the model seems not to capture subsequent shifts in metabolic activities observed experimentally under low-nutrient regimes. Some discrepancies can be explained by the multiplicity of possible fermentative states for F. prausnitzii. In general, these results provide valuable guidelines for design of future experiments aimed at better determining the mechanisms leading to enhanced butyrate in this ecosystem.https://www.biorxiv.org/content/10.1101/444760v1https://www.biorxiv.org/content/10.1101/444760v1Othe