9,277 research outputs found
Many-Task Computing and Blue Waters
This report discusses many-task computing (MTC) generically and in the
context of the proposed Blue Waters systems, which is planned to be the largest
NSF-funded supercomputer when it begins production use in 2012. The aim of this
report is to inform the BW project about MTC, including understanding aspects
of MTC applications that can be used to characterize the domain and
understanding the implications of these aspects to middleware and policies.
Many MTC applications do not neatly fit the stereotypes of high-performance
computing (HPC) or high-throughput computing (HTC) applications. Like HTC
applications, by definition MTC applications are structured as graphs of
discrete tasks, with explicit input and output dependencies forming the graph
edges. However, MTC applications have significant features that distinguish
them from typical HTC applications. In particular, different engineering
constraints for hardware and software must be met in order to support these
applications. HTC applications have traditionally run on platforms such as
grids and clusters, through either workflow systems or parallel programming
systems. MTC applications, in contrast, will often demand a short time to
solution, may be communication intensive or data intensive, and may comprise
very short tasks. Therefore, hardware and software for MTC must be engineered
to support the additional communication and I/O and must minimize task dispatch
overheads. The hardware of large-scale HPC systems, with its high degree of
parallelism and support for intensive communication, is well suited for MTC
applications. However, HPC systems often lack a dynamic resource-provisioning
feature, are not ideal for task communication via the file system, and have an
I/O system that is not optimized for MTC-style applications. Hence, additional
software support is likely to be required to gain full benefit from the HPC
hardware
Predicting Intermediate Storage Performance for Workflow Applications
Configuring a storage system to better serve an application is a challenging
task complicated by a multidimensional, discrete configuration space and the
high cost of space exploration (e.g., by running the application with different
storage configurations). To enable selecting the best configuration in a
reasonable time, we design an end-to-end performance prediction mechanism that
estimates the turn-around time of an application using storage system under a
given configuration. This approach focuses on a generic object-based storage
system design, supports exploring the impact of optimizations targeting
workflow applications (e.g., various data placement schemes) in addition to
other, more traditional, configuration knobs (e.g., stripe size or replication
level), and models the system operation at data-chunk and control message
level.
This paper presents our experience to date with designing and using this
prediction mechanism. We evaluate this mechanism using micro- as well as
synthetic benchmarks mimicking real workflow applications, and a real
application.. A preliminary evaluation shows that we are on a good track to
meet our objectives: it can scale to model a workflow application run on an
entire cluster while offering an over 200x speedup factor (normalized by
resource) compared to running the actual application, and can achieve, in the
limited number of scenarios we study, a prediction accuracy that enables
identifying the best storage system configuration
Model Checker Execution Reports
Software model checking constitutes an undecidable problem and, as such, even
an ideal tool will in some cases fail to give a conclusive answer. In practice,
software model checkers fail often and usually do not provide any information
on what was effectively checked. The purpose of this work is to provide a
conceptual framing to extend software model checkers in a way that allows users
to access information about incomplete checks. We characterize the information
that model checkers themselves can provide, in terms of analyzed traces, i.e.
sequences of statements, and safe cones, and present the notion of execution
reports, which we also formalize. We instantiate these concepts for a family of
techniques based on Abstract Reachability Trees and implement the approach
using the software model checker CPAchecker. We evaluate our approach
empirically and provide examples to illustrate the execution reports produced
and the information that can be extracted
MCMC-ODPR : primer design optimization using Markov Chain Monte Carlo sampling
Background
Next generation sequencing technologies often require numerous primer designs that require good target coverage that can be financially costly. We aimed to develop a system that would implement primer reuse to design degenerate primers that could be designed around SNPs, thus find the fewest necessary primers and the lowest cost whilst maintaining an acceptable coverage and provide a cost effective solution. We have implemented Metropolis-Hastings Markov Chain Monte Carlo for optimizing primer reuse. We call it the Markov Chain Monte Carlo Optimized Degenerate Primer Reuse (MCMC-ODPR) algorithm.
Results
After repeating the program 1020 times to assess the variance, an average of 17.14% fewer primers were found to be necessary using MCMC-ODPR for an equivalent coverage without implementing primer reuse. The algorithm was able to reuse primers up to five times. We compared MCMC-ODPR with single sequence primer design programs Primer3 and Primer-BLAST and achieved a lower primer cost per amplicon base covered of 0.21 and 0.19 and 0.18 primer nucleotides on three separate gene sequences, respectively. With multiple sequences, MCMC-ODPR achieved a lower cost per base covered of 0.19 than programs BatchPrimer3 and PAMPS, which achieved 0.25 and 0.64 primer nucleotides, respectively.
Conclusions
MCMC-ODPR is a useful tool for designing primers at various melting temperatures at good target coverage. By combining degeneracy with optimal primer reuse the user may increase coverage of sequences amplified by the designed primers at significantly lower costs. Our analyses showed that overall MCMC-ODPR outperformed the other primer-design programs in our study in terms of cost per covered base
Empowering parallel computing with field programmable gate arrays
After more than 30 years, reconļ¬gurable computing has grown from a concept to a mature ļ¬eld of science and technology. The cornerstone of this evolution is the ļ¬eld programmable gate array, a building block enabling the conļ¬guration of a custom hardware architecture. The departure from static von Neumannlike architectures opens the way to eliminate the instruction overhead and to optimize the execution speed and power consumption. FPGAs now live in a growing ecosystem of development tools, enabling software programmers to map algorithms directly onto hardware. Applications abound in many directions, including data centers, IoT, AI, image processing and space exploration. The increasing success of FPGAs is largely due to an improved toolchain with solid high-level synthesis support as well as a better integration with processor and memory systems. On the other hand, long compile times and complex design exploration remain areas for improvement. In this paper we address the evolution of FPGAs towards advanced multi-functional accelerators, discuss different programming models and their HLS language implementations, as well as high-performance tuning of FPGAs integrated into a heterogeneous platform. We pinpoint fallacies and pitfalls, and identify opportunities for language enhancements and architectural reļ¬nements
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