Comparison of 3D reconstruction of mandible for preoperative planning using commercial and open-source software

3D printing of mandible is important for pre-operative planning, diagnostic purposes, as well as for education and training. Currently, the processing of CT data is routinely performed with commercial software which increases the cost of operation and patient management for a small clinical setting. Usage of open-source software as an alternative to commercial software for 3D reconstruction of the mandible from CT data is scarce. The aim of this study is to compare two methods of 3D reconstruction of the mandible using commercial Materialise Mimics software and open-source Medical Imaging Interaction Toolkit (MITK) software. Head CT images with a slice thickness of 1 mm and a matrix of 512x512 pixels each were retrieved from the server located at the Radiology Department of Hospital Universiti Sains Malaysia. The CT data were analysed and the 3D models of mandible were reconstructed using both commercial Materialise Mimics and open-source MITK software. Both virtual 3D models were saved in STL format and exported to 3matic and MeshLab software for morphometric and image analyses. Both models were compared using Wilcoxon Signed Rank Test and Hausdorff Distance. No significant differences were obtained between the 3D models of the mandible produced using Mimics and MITK software. The 3D model of the mandible produced using MITK open-source software is comparable to the commercial MIMICS software. Therefore, open-source software could be used in clinical setting for pre-operative planning to minimise the operational cost

PRELIMINARY FINDINGS OF A POTENZIATED PIEZOSURGERGICAL DEVICE AT THE RABBIT SKULL

The number of available ultrasonic osteotomes has remarkably increased. In vitro and in vivo studies have revealed differences between conventional osteotomes, such as rotating or sawing devices, and ultrasound-supported osteotomes (Piezosurgery®) regarding the micromorphology and roughness values of osteotomized bone surfaces. Objective: the present study compares the micro-morphologies and roughness values of osteotomized bone surfaces after the application of rotating and sawing devices, Piezosurgery Medical® and Piezosurgery Medical New Generation Powerful Handpiece. Methods: Fresh, standard-sized bony samples were taken from a rabbit skull using the following osteotomes: rotating and sawing devices, Piezosurgery Medical® and a Piezosurgery Medical New Generation Powerful Handpiece. The required duration of time for each osteotomy was recorded. Micromorphologies and roughness values to characterize the bone surfaces following the different osteotomy methods were described. The prepared surfaces were examined via light microscopy, environmental surface electron microscopy (ESEM), transmission electron microscopy (TEM), confocal laser scanning microscopy (CLSM) and atomic force microscopy. The selective cutting of mineralized tissues while preserving adjacent soft tissue (dura mater and nervous tissue) was studied. Bone necrosis of the osteotomy sites and the vitality of the osteocytes near the sectional plane were investigated, as well as the proportion of apoptosis or cell degeneration. Results and Conclusions: The potential positive effects on bone healing and reossification associated with different devices were evaluated and the comparative analysis among the different devices used was performed, in order to determine the best osteotomes to be employed during cranio-facial surgery

Issues in Contemporary Orthodontics

Issues in Contemporary Orthodontics is a contribution to the ongoing debate in orthodontics, a discipline of continuous evolution, drawing from new technology and collective experience, to better meet the needs of students, residents, and practitioners of orthodontics. The book provides a comprehensive view of the major issues in orthodontics that have featured in recent debates. Abroad variety of topics is covered, including the impact of malocclusion, risk management and treatment, and innovation in orthodontics

Performance Factors in Neurosurgical Simulation and Augmented Reality Image Guidance

Virtual reality surgical simulators have seen widespread adoption in an effort to provide safe, cost-effective and realistic practice of surgical skills. However, the majority of these simulators focus on training low-level technical skills, providing only prototypical surgical cases. For many complex procedures, this approach is deficient in representing anatomical variations that present clinically, failing to challenge users’ higher-level cognitive skills important for navigation and targeting. Surgical simulators offer the means to not only simulate any case conceivable, but to test novel approaches and examine factors that influence performance. Unfortunately, there is a void in the literature surrounding these questions. This thesis was motivated by the need to expand the role of surgical simulators to provide users with clinically relevant scenarios and evaluate human performance in relation to image guidance technologies, patient-specific anatomy, and cognitive abilities. To this end, various tools and methodologies were developed to examine cognitive abilities and knowledge, simulate procedures, and guide complex interventions all within a neurosurgical context. The first chapter provides an introduction to the material. The second chapter describes the development and evaluation of a virtual anatomical training and examination tool. The results suggest that learning occurs and that spatial reasoning ability is an important performance predictor, but subordinate to anatomical knowledge. The third chapter outlines development of automation tools to enable efficient simulation studies and data management. In the fourth chapter, subjects perform abstract targeting tasks on ellipsoid targets with and without augmented reality guidance. While the guidance tool improved accuracy, performance with the tool was strongly tied to target depth estimation – an important consideration for implementation and training with similar guidance tools. In the fifth chapter, neurosurgically experienced subjects were recruited to perform simulated ventriculostomies. Results showed anatomical variations influence performance and could impact outcome. Augmented reality guidance showed no marked improvement in performance, but exhibited a mild learning curve, indicating that additional training may be warranted. The final chapter summarizes the work presented. Our results and novel evaluative methodologies lay the groundwork for further investigation into simulators as versatile research tools to explore performance factors in simulated surgical procedures

Application Of Morphometric Analysis And Tissue Engineering To Bioengineering Personalised Autologous Bone Tissues For The Reconstruction Of Congenital Midface Deformities

Congenital craniofacial bone deformities frequently occur in conditions such as Craniofacial microsomia (CM) and Treacher Collins Syndrome (TCS). Affected children may suffer from functional impairment and poor self-esteem. Reconstruction aims to restore form and function but often involves multiple invasive surgeries throughout childhood. The reliance on foreign-body implants and autologous tissue-transfer is also associated with morbidity. The aim of this work was to assess whether morphometric analysis and tissue engineering using paediatric adipose derived stem cells could facilitate bioengineering personalised autologous facial bone implants to provide a more accurate and life-long solution for the treatment of midface deformities. Paediatric facial CT scans (n=70) from control, CM and TCS subjects were used to build a dense surface model of the midface to study normal and dysmorphic postnatal midface development. This enabled relating of soft and skeletal tissue growth, analysis of asymmetry and evaluation of surgical correction. This work also establishes the foundations for developing a surgical planning tool. Paediatric craniofacial bone was also analysed in order to establish a reference for tissue engineering and reverse engineer the bone microenvironment to fabricate biomaterials and culture conditions that enhance osteogenic maturation. It was possible to bioengineer bone tissue using hADSC cultured on a bone biomimetic hybrid POSS-PCL-Fibrin scaffold. Cellularised scaffolds survived subcutaneous implantation in nude mice for 4 months, underwent vascularisation and showed evidence of mature extracellular matrix formation and cellular composition similar to native bone The results of this work support a multi-faceted approach to bone tissue engineering. Increased understanding of paediatric facial bones permits recreation of the bone microenvironment to enable osteogenic maturation of hADSC. These tissues could eventually be custom-shaped using an operative planning tool based on these computer models. Future work using larger data sets, bioreactors, 3D printing and large animal defect models will seek to build on these promising results