15,945 research outputs found

    Tinea capitis : an√°lise em hospital universit√°rio terci√°rio da √°rea de Lisboa (Agosto de 2018 a Maio de 2020)

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    Tese de mestrado, Microbiologia Cl√≠nica e Doen√ßas Infecciosas Emergentes, Universidade de Lisboa, Faculdade de Medicina, 2021A tinea capitis √© uma infe√ß√£o dermatof√≠tica do couro cabeludo, que acomete principalmente crian√ßas entre tr√™s e oito anos e tem impacto social relevante. A les√£o prim√°ria pode evoluir para alopecia cicatricial como sequela. A presente tese teve com objetivo relatar as esp√©cies de tinea capitis prevalentes na regi√£o de Lisboa, identificar a faixa et√°ria mais atingida, comparar estatisticamente os resultados entre os principais meios de diagn√≥stico (exame direto e cultivo micol√≥gico), otimizar o diagn√≥stico definitivo com a associa√ß√£o de exames de rea√ß√£o em cadeia da polimerase (PCR) e sequencia√ß√£o de amostras obtidas de col√≥nias de fungos dermat√≥fitos. Foram estudadas 248 amostras cl√≠nicas com diagn√≥stico presuntivo de tinea capitis de doentes atendidos no servi√ßo de Dermatologia do Hospital de Santa Maria (um hospital universit√°rio terci√°rio), Lisboa, no per√≠odo entre agosto de 2018 e maio de 2020. Das amostras analisadas, 111 foram positivas, somando-se os resultados dos exames direto e de cultura. Foram identificados dermat√≥fitos no cultivo micol√≥gico em 102 amostras: 48 casos de Microsporum audouinii (47,06%), 37 de Trichophyton soudanense (36,28%), 9 de Trichophyton tonsurans (8,82%), 2 de Trichophyton mentagrophytes (1,96%), 1 de Microsporum canis (0,98%), 3 em que n√£o foi poss√≠vel diferenciar Microsporum audouinii de Microsporum canis (2,94%) e 2 em que n√£o foi poss√≠vel a diferencia√ß√£o entre Trichophyton soudanense e Trichophyton violaceum (1,96%). Dos exames positivos, 33% dos doentes eram declarados como pertencentes ao fototipo V ou VI. A identifica√ß√£o de dermat√≥fitos por PCR-sequencia√ß√£o esteve em concord√Ęncia significativa com a identifica√ß√£o microsc√≥pica das col√īnias cultivadas.Tinea capitis is a dermatophytic infection of the scalp, which mainly affects children aged between three and eight years and has a relevant social impact. The primary lesion may progress to cicatricial alopecia as a sequel. This study aimed at reporting the species of tinea capitis in the Lisbon region, describing age and sex of affected patients, comparing statistically the results between the main means of diagnosis (direct examination and mycological cultivation), and optimizing the diagnosis with the association of polymerase chain reaction (PCR) followed by sequencing assays performed on clinical samples and fungal colonies. A total of 248 clinical samples with a presumptive diagnosis of tinea capitis were studied, from patients treated at the Dermatology Department of Hospital de Santa Maria (a tertiary, referral and teaching Hospital), Lisboa, between August 2018 and May 2020. A total of 111 tests were considered positive, comprising the results of both direct examinations of clinical samples plus the macroscopic and microscopic examination of fungal cultures. Dermatophytes were identified in the mycological culture in 102 cases: 48 cases of Microsporum audouinii (47.04%), 37 of Trichophyton soudanense (33.34%), 9 of Trichophyton tonsurans (8.82%), 2 of Trichophyton mentagrophytes (1.96%), and 1 of Microsporum canis (0.98%). In 3 and 2 cases, respectively, it was not possible to differentiate between Microsporum audouinii and Microsporum canis (2.94%), and between Trichophyton soudanense and Trichophyton violaceum (1.96%). Of the positive cases, 33% referred to patients declared to belong to phototype V or VI. The identification of dermatophytes by PCR-sequencing were in excellent agreement with their identification based on microscopic examination of fungal colonies

    DERMATITE POR MALASSEZIA PACHYDERMATIS ASSOCIADA A CISTO OVARIANO

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    Malassezia pachydermatis is an opportunistic pathogen and in dogs the increased prevalence of this fungus is generally associated with a primary cause, resulting in dermatitis. This work aimed to report the case of a dog with a recurrence of Malassezia pachydermatis, correlated to the simultaneous occurrence of ovarian cysts, addressing the clinical aspects, diagnosis, and animal treatment. An 8-year-old Golden Retriever dog, with a body weight of 35kg, not castrated, presented itching and erythema on some parts of the body, mainly on the snout, ears, and paws. The dog was active, eating, drinking, and playing normally. Moreover, it was also reported that the dog was going into heat approximately every 4 months, being diagnosed with an ovarian cyst through ultrasound imaging. The diagnosis was made based on cytological examination, fungal culture, and skin scrapings, where the exacerbated presence of malasseziosis was confirmed. Ovarian hysterectomy surgery was performed and treatment for malasseziosis consisted of systemic and topical antifungals. The result was positive with no recurrence after 9 months. The dog showed excellent recovery during the treatment period and due to the non-occurrence of recurrence, it is assumed that immunosuppression could be caused by irregular heats as a result of some hormonal disorder. It was concluded that it is important to carry out additional tests so that the best treatment for each disease can be instituted.Malassezia pachydermatis √© um pat√≥geno oportunista sendo que em c√£es o aumento da preval√™ncia desse fungo est√° geralmente associado a uma causa prim√°ria, causando dermatites. O objetivo deste trabalho foi relatar o caso de uma cadela com recidiva de Malassezia pachydermatis, correlacionado √† ocorr√™ncia simult√Ęnea de cistos no ov√°rio, abordando os aspectos cl√≠nicos, o diagn√≥stico e o tratamento do animal. Uma cadela da ra√ßa Golden Retriever, de 8 anos de idade, com peso corporal de 35kg, n√£o castrada, apresentava prurido e eritema em algumas partes do corpo, principalmente na parte do focinho, orelha e patas. A cadela estava ativa, comendo, bebendo e brincando normalmente. Al√©m disso, tamb√©m foi reportado que a mesma estava est√° entrando no cio aproximadamente a cada 4 meses, sendo diagnosticada com cisto no ov√°rio atrav√©s do exame de imagem ultrassonogr√°fica. O diagn√≥stico foi realizado a partir de exame citol√≥gico, cultivo f√ļngico e raspado de pele, onde foi confirmada a presen√ßa exacerbada da malasseziose. Foi realizada a cirurgia de ov√°rio histerectomia e o tratamento para malasseziose constituiu-se de antif√ļngicos sist√™mico e t√≥pico. O resultado foi positivo n√£o havendo recidiva ap√≥s 9 meses passados. A cadela apresentou excelente recupera√ß√£o durante o per√≠odo de tratamento e devido √† n√£o ocorr√™ncia de recidiva, pressup√Ķe-se que uma imunossupress√£o poderia estar sendo ocasionada pelos cios irregulares em decorr√™ncia de algum dist√ļrbio hormonal. Concluiu-se que √© importante a realiza√ß√£o de exames complementares para que se possa instituir o melhor tratamento para cada doen√ßa

    An√°lise do estoque domiciliar de medicamentos de usu√°rios da Estrat√©gia Sa√ļde da Fam√≠lia, em Rondon√≥polis - MT, Brasil

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    It is common for Brazilian families to store medications, whether for continuous use, leftover from treatment, due to abandonment, or for self-medication. Thus, this study aimed to analyze the home drug storage of the population attached to the Family Health Strategy (FHS) in Rondon√≥polis-MT from February to June 2022, to assess storage conditions, conduct a survey of all pharmaceuticals in the households in their different pharmaceutical forms, and identify the medication use profile according to their therapeutic indications. This was a cross-sectional, exploratory, descriptive-based study. A questionnaire was administered to each household during home visits. Regarding the study sample, 83.9% (n=281) of the respondents were female, predominantly over 40 years old, with a low level of education and lower family income. Of the participants, 97.6% had home pharmacies. These medications were primarily stored in kitchens, bedrooms, and living rooms. The most numerous therapeutic classes were analgesics (14.2%), NSAIDs (8.9%), and antihypertensive drugs (7.7%). The quantity of stored medications was significantly higher among those practicing self-medication and participants with inadequate knowledge about medication use, revealing the need for pharmacists as promoters of health education actions on rational drug use.√Č comum o armazenamento de medicamentos pelas fam√≠lias brasileiras, seja por uso cont√≠nuo, por sobras de um tratamento, pelo abandono ou para a automedica√ß√£o. Dessa maneira o presente estudo objetiva analisar o estoque domiciliar de medicamentos da popula√ß√£o adstrita na Estrat√©gia Sa√ļde da Fam√≠lia (ESF) de Rondon√≥polis-MT de fevereiro a junho de 2022, visando analisar as condi√ß√Ķes de armazenamento, realizar o levantamento de todos os f√°rmacos dos domic√≠lios em suas diferentes formas farmac√™uticas e identificar o perfil de uso dos medicamentos conforme suas indica√ß√Ķes terap√™uticas. Trata-se de um estudo transversal, de car√°ter explorat√≥rio, e de base descritiva. Foi aplicado um question√°rio por domic√≠lio durante visita domiciliar. Sobre a amostra estudada, 83,9% (n=281) dos entrevistados era do sexo feminino, faixa et√°ria com predom√≠nio de pessoas acima de 40 anos, com um n√≠vel de escolaridade baixo e renda familiar mais baixa. Dos participantes da pesquisa, 97,6% possu√≠am farm√°cia caseira. Esses medicamentos eram armazenados principalmente na cozinha, no quarto e na sala. As classes terap√™uticas mais numerosas foram: analg√©sicos (14,2%), AINEs (8,9%) e anti-hipertensivos (7,7%). A quantidade de medicamentos armazenados foi significativamente maior entre praticantes de automedica√ß√£o e participantes sem conhecimento adequado sobre o uso dos medicamentos, revelando a necessidade do farmac√™utico como promotor de a√ß√Ķes de educa√ß√£o em sa√ļde sobre uso racional de medicamentos

    CANCER DE PELE NÃO MELANOMA: REVISÃO INTEGRATIVA

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    Introduction: Non-melanoma skin cancer (NMSC) comprises a group of neoplasms with a high incidence in the world population. It is divided into basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). As it is highly prevalent, understanding the process of oncogenesis and the relationship with ions, proteins and cellular receptors in CPMN can contribute to the evaluation of new therapies. Objective: To understand the oncogenesis process of non-melanoma skin tumors and its relationship with the immunolocalization of IP3R. Method: Integrative literature review with evidence synthesis. The database was PUBMED; the search strategy: ‚Äúsquamous cell carcinoma, AND/OR basal cell carcinoma, AND/OR IP3R, AND/OR immunohistochemistry‚ÄĚ. Works published between 2018 and 2023 were considered for review; 40 works were included, fully read and summarized. Results: NMSC is the most common malignant tumor worldwide, with 75-80% being BCC, and up to 25% being SCC. Molecular interactions in general involve a large participation of tumor suppressor molecules, as well as procto-oncogenes. Furthermore, voltage-dependent ion channels control the cytosolic flow of ions, including calcium. The IP3R (phosphatidyl inositol-3 receptor) allows the exit of calcium from the endoplasmic reticulum so that it can be used by the cell for physiological activities such as proliferation, angiogenesis, motility and invasion capacity. Conclusion: The IP3R, due to its immunohistochemical expression characteristics, appears may also be related to the pathophysiology of NMSC.Introdu√ß√£o: O c√Ęncer de pele n√£o melanoma (CPNM) compeende grupo de neoplasias com alta incid√™ncia na popula√ß√£o mundial. √Č dividido em carcinoma basocelular (CBC) e de c√©lulas escamosas (CEC). Por ser de grande preval√™ncia, entender o processo de oncog√™nese e a rela√ß√£o com √≠ons, prote√≠nas e receptores celulares no CPMN pode contribuir para que novas terap√™uticas sejam avaliadas. Objetivo: Entender o processo da oncog√™nese dos tumores de pele n√£o melanomas e sua rela√ß√£o com a imunolocaliza√ß√£o do IP3R. M√©todo: Revis√£o integrativa da literatura com s√≠ntese de evid√™ncias. A base de dados foi o PUBMED; a ¬†estrat√©gia de busca: ‚Äúcarcinoma espinocelular, AND/OR carcinoma basocelular, AND/OR IP3R, AND/OR imunoistoqu√≠mica‚ÄĚ. Foram considerados para revis√£o os trabalhos publicados entre 2018 e 2023. Foram inclu√≠dos 40 trabalhos, integralmente lidos e resumidos. Resultados: CPNMs s√£o os tumores malignos mais comuns em todo o mundo, sendo 75-80% o CBC, e at√© 25% o CEC. As intera√ß√Ķes moleculares de forma geral, envolvem grande participa√ß√£o de mol√©culas supressoras tumorais, assim como de procto-oncogenes. Al√©m disso, canais i√īnicos voltagem dependente controlam o fluxo citos√≥lico de √≠ons, dentre eles o c√°lcio. O IP3R (receptor do fosfatidil inositol-3) permite a sa√≠da de c√°lcio do ret√≠culo endoplasm√°tico para que seja utilizado pela c√©lula para atividades fisiol√≥gias como prolifera√ß√£o, angiog√™nese, motilidade e capacidade de invas√£o. Conclus√£o: O IP3R, pelas caracter√≠sticas de express√£o imunoistoqu√≠mica, parece estar relacionado tamb√©m, √† fisiopatologia do CPNM

    Neurofibroma orbitofacial espont√Ęneo em uma matriz su√≠na

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    Neurofibromas are neoplasms derived from nerve bundles and are frequent in humans but not common in animals. This report described the macroscopic, histologic, and immunohistochemistry findings of an orbitofacial neurofibroma in a sow. The sow presented left eyelids with marked expansion, associated with severe ectropion and reddening of both conjunctival mucosae. The mass on the cutting surface was homogeneous, with a light tan, and shiny, measuring 9.0 x 7.0 x 7.0 cm in width, compressing the eyeball. Microscopically, there was paucicellular neoplastic proliferation of elongated cells amid the accentuated myxoid matrix. There were multifocal areas where welldifferentiated nervous fascicles and skeletal musculature were seen. Neoplastic cells were immunostained positive for GFAP, neurofilament, S-100, Sox-10, and vimentin. Cytokeratin showed immunolabeling around primitive nerve bundles and desmin around neoformed vessels and muscle bundles within the tumor. Orbitopalpebral and orbitofacial neurofibroma, despite being common in humans, have not been described in domestic pigs and should be considered as a differential diagnosis in eyelid tumors in pigs.Neurofibromas são neoplasias derivadas dos feixes nervosos e são frequentes em humanos, mas incomuns em espécies animais domésticos. Esse relato tem como objetivo descrever os achados macroscópicos, histológicos e imuno-histoquímicos de um neurofibroma orbitofacial em uma matriz suína. O animal apresentava as pálpebras esquerdas acentuadamente expandidas, associada a severo ectrópio e avermelhamento de ambas as mucosas conjuntivais. A tumoração palpebral, na superfície de corte, era homogênea, levemente acastanhada e brilhante, medindo 9,0 x 7,0 x 7,0 cm, e comprimia o globo ocular. Microscopicamente foi observada uma proliferação neoplásica pobremente celular de células alongadas no meio de uma acentuada quantidade de matriz mixoide. Havia áreas intratumorias multifocais onde fascículos nervosos bem diferenciados e musculatura esquelética foram observados. As células neoplásicas foram positivas na imuno-histoquímica para GFAP, neurofilamento, S-100, Sox-10 e vimentina. Citoqueratina mostrou uma imunomarcação ao redor de feixes nervosos primitivos e desmina ao redor de vasos neoformados e feixes musculares dentro do tumor. O neurofibroma orbitofacial, apesar de comum em humanos, nunca foi descrito em suínos domésticos e deve ser considerado um diagnóstico diferencial para neoplasias palpebrais em suínos

    Result√Ęncias fisiobiol√≥gicas da radia√ß√£o ultravioleta e suas fun√ß√Ķes na carcinog√™nese de pele

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    The aim of this study is to expose the effects that solar radiation causes to the human body and identify its role in skin carcinogenesis. This is a narrative review, where a search for articles was carried out in the Medical Literature Analysis and Retrievel System Online (MEDLINE) and Scientific Electronic Library Online (SciELO) databases, with the following Health Sciences Descriptors (DeCS): Cancer; Skin; Radiation; combined with each other using the Boolean operators "AND" and "OR". Selecting articles between the periods of 2011 and 2022, in English, Portuguese and Spanish, to increase the level of relevance and quality of the review, in addition to the technical-scientific basis coming from literary works renowned in history. In relation to skin cancer , UV radiation plays a complete role in oncogenesis, after all it modifies the physiobiological functions of cells and their architecture. Changes in the DNA of cells, the frequency and amount of sun exposure, are the factors that lead to cancer over time, especially in regions with greater exposure. Therefore, there is a need to change lifestyle habits, such as using chemical sunscreens and thick clothing, increasing skin protection. In addition to raising awareness among the population about the warning signs of the tumor and its characteristics, so that early access to health units and therapy can minimize its effects. Scientific research should also be encouraged, after all, cancer continues to be a disease that needs to be radicalized.El objetivo de este estudio es exponer los efectos que la radiaci√≥n solar provoca en el cuerpo humano e identificar su papel en la carcinog√©nesis cut√°nea. Se trata de una revisi√≥n narrativa, donde se realiz√≥ una b√ļsqueda de art√≠culos en las bases de datos Medical Literature Analysis and Retrievel System Online (MEDLINE) y Scientific Electronic Library Online (SciELO), con los siguientes Descriptores en Ciencias de la Salud (DeCS): C√°ncer; Piel; Radiaci√≥n; combinados entre s√≠ mediante los operadores booleanos "Y" y "O". Seleccionar art√≠culos entre los per√≠odos de 2011 y 2022, en ingl√©s, portugu√©s y espa√Īol, para incrementar el nivel de relevancia y calidad de la rese√Īa, adem√°s de la base t√©cnico-cient√≠fica proveniente de obras literarias de renombre en la historia. En relaci√≥n con el c√°ncer de piel, la radiaci√≥n UV juega un papel completo en la oncog√©nesis, al fin y al cabo modifica las funciones fisiobiol√≥gicas de las c√©lulas y su arquitectura. Los cambios en el ADN de las c√©lulas, la frecuencia y cantidad de exposici√≥n al sol, son los factores que conducen al c√°ncer con el tiempo, especialmente en regiones con mayor exposici√≥n. Por ello, surge la necesidad de cambiar h√°bitos de vida, como el uso de protectores solares qu√≠micos y ropa gruesa, aumentando la protecci√≥n de la piel. Adem√°s de concientizar a la poblaci√≥n sobre las se√Īales de alerta del tumor y sus caracter√≠sticas, para que el acceso temprano a las unidades de salud y la terapia puedan minimizar sus efectos. Tambi√©n se debe fomentar la investigaci√≥n cient√≠fica, al fin y al cabo, el c√°ncer sigue siendo una enfermedad que hay que radicalizar.Objetiva-se, neste estudo, expor os efeitos que a radia√ß√£o solar provoca ao organismo humano e identificar o seu papel na carcinog√™nese de pele. Trata-se de uma revis√£o narrativa, onde foi realizada  uma  pesquisa  de  artigos  nas  bases  de  dados  Medical Literature Analysis and Retrievel System Online (MEDLINE) e Scientific Electronic Library Online (SciELO), com os  seguintes  Descritores  em  Ci√™ncias  da  Sa√ļde (DeCS): C√Ęncer; Pele; Radia√ß√£o; combinados entre si utilizando os operadores booleanos  "AND"  e "OR". Selecionando artigos entre os per√≠odos de 2011 a 2022, nos idiomas Ingl√™s, Portugu√™s e Espanhol, para ampliar o n√≠vel de relev√Ęncia e a qualidade da revis√£o, al√©m do embasamento t√©cnico-cient√≠fico advindo de obras liter√°rias conceituadas pela hist√≥ria.Com rela√ß√£o ao c√Ęncer de pele, a radia√ß√£o UV tem total papel na oncog√™nese, afinal modifica as fun√ß√Ķes fisiobiol√≥gicas das c√©lulas e sua arquitetura. As altera√ß√Ķes de DNA das c√©lulas, a frequencia e quantidade de exposi√ß√£o solar, s√£o os fatores que proporcionam, com o tempo, o c√Ęncer, sobretudo, em regi√Ķes com maior exposi√ß√£o. Logo, h√° necessidade de alterar h√°bitos de vida, como utilizar protetores qu√≠micos contra os raios solares e roupas grossas, aumentando a prote√ß√£o da pele. Al√©m de conscientizar a popula√ß√£o sobre os sinais de alerta do tumor e sobre suas caracter√≠sticas, para que o acesso precoce a unidades de sa√ļde e a terap√™utica consiga minimizar seus efeitos. Pesquisas cient√≠ficas tamb√©m deveriam ser incentivadas, afinal, o c√Ęncer continua sendo uma doen√ßa que necessita ser radicalizada.&nbsp

    AtopyReg¬ģ, the Prospective Italian Patient Registry for Moderate‚Äźto‚ÄźSevere Atopic Dermatitis in Adults: Baseline Demographics, Disease Characteristics, Comorbidities, and Treatment History

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    Background and Objective AtopyReg¬ģ is a multicenter, prospective, observational, non-profit cohort study on moderate-tosevere atopic dermatitis in adults promoted in 2018 by the Italian Society of Dermatology and Venereology (SIDeMaST). We aimed to describe baseline demographics, disease characteristics, comorbidities, and therapeutic data of adult patients affected by moderate-to-severe atopic dermatitis. Methods Patients were selected based on the following inclusion criteria: age ‚Č• 18 years; Eczema Area and Severity Index score ‚Č• 16 or localization in visible or sensitive areas (face, neck, hands, or genitalia), or a Numeric Rating Scale itch score ‚Č• 7 or a Numeric Rating Scale sleep loss score ‚Č• 7, or a Dermatology Life Quality Index score ‚Č• 10. Demographic and clinical data at baseline were recorded and analyzed. Results A total of 1170 patients (male 51.1%; mean age: 44.7 years; range 18‚Äď90 years) were enrolled by 12 Italian Dermatology Units between January 2019 and November 2022. Skin lesions were eczematous in 83.2% of patients, the most involved site were the flexures (53.9%), face (50.9%), and neck (48.0%). Mean Eczema Area and Severity Index score was 22.3, mean Dermatology Life Quality Index value was 17.6, mean Patient Oriented Eczema Measure score was 13.1, and mean Numeric Rating Scale itch and sleep loss scores were 7.6 and 5.9, respectively. Previous systemic therapies were corticosteroids in 77.7% of patients, antihistamines in 50.3% of patients, and cyclosporine A in 42.6% of patients. Conclusions This baseline data analysis deriving from AtopyReg ¬ģ provides real-life evidence on patients with moderateto- severe atopic dermatitis in Italy confirming the high burden of atopic dermatitis with a significant impact on patients‚Äô quality of life

    Perfil de sensibiliza√ß√£o de c√£es com dermatite at√≥pica na √Ārea Metropolitana de Lisboa

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    Disserta√ß√£o de Mestrado Integrado em Medicina Veterin√°ria, √°rea cient√≠fica de Cl√≠nicaA dermatite at√≥pica canina (DAc) √© uma doen√ßa pruriginosa, inflamat√≥ria e cr√≥nica da pele, que resulta da intera√ß√£o de fatores gen√©ticos e ambientais, podendo refletir a hipersensibiliza√ß√£o a alerg√©nios ambientais (non-food-induced atopic dermatitis - NFIAD). O diagn√≥stico de NFIAD consiste na exclus√£o de outras entidades capazes de mimetizar sinais cl√≠nicos, seguindo-se a identifica√ß√£o dos alerg√©nios aos quais o can√≠deo sensibilizou, maioritariamente, por teste intrad√©rmico (TID) ou serol√≥gico (SAT). O principal objetivo do presente estudo consistiu em identificar frequ√™ncias de sensibiliza√ß√£o a alerg√©nios no seio de uma popula√ß√£o canina, comparando-os com dados previamente reportados. Para tal, identificaram-se can√≠deos diagnosticados com NFIAD residentes na √Ārea Metropolitana de Lisboa que realizaram TID no Servi√ßo de Dermatologia do Hospital Escolar Veterin√°rio (HEV), no per√≠odo compreendido entre 2012 e 2017, bem como de c√£es que efetuaram SAT por interm√©dio de um laborat√≥rio externo, entre 2019 e 2022. Um total de 257 can√≠deos realizaram provas alergol√≥gicas, dos quais 13,23% (n=34) apresentaram resultados negativos. Desta forma, integraram o estudo 223 can√≠deos com resultados positivos, 118 recorrendo a TID e 105 atrav√©s de SAT. O grupo de alerg√©nios que registou a maior frequ√™ncia de sensibiliza√ß√Ķes foi o dos √°caros dom√©sticos, com 86,44% nos TIDs e 87,62% nos SATs. Neste grupo, verificou-se que a positividade a dois ou mais √°caros ocorreu em mais de 92% dos indiv√≠duos, sendo a situa√ß√£o mais frequente, a sensibiliza√ß√£o a tr√™s √°caros (29.38%), seguindo-se a positividade aos 5 √°caros em estudos (28,35%). Dermatophagoides farinae registou a maior frequ√™ncia individual nos TIDs (75,42%) e nos SATs (74,29%). O grupo dos p√≥lenes foi o segundo com a maior frequ√™ncia de sensibiliza√ß√Ķes (44,07% nos TIDs e 30,48% nos SATs). Dentro deste grupo, o tipo pol√≠nico com maior frequ√™ncia de sensibiliza√ß√£o foi o de gram√≠neas, o qual apresentou 29,66% nos TIDs e 21.9% nos SATs. O p√≥len de Festuca pratensis nos TIDs (12,71%) e o p√≥len de Cynodon dactylon (16,19%) nos SATs foram aqueles que registaram as maiores frequ√™ncias dentro deste grupo. No grupo dos fungos, observou-se uma frequ√™ncia de sensibiliza√ß√£o de 25,42% nos TIDs e 24,76% nos SATs, destacando-se Malassezia pachydermatis (22,03% nos TIDs e 16,19% nos SATs). A compara√ß√£o com resultados previamente publicados identificou novos padr√Ķes de sensibiliza√ß√£o caninos, sendo pioneiro no per√≠odo considerado. Destacou-se o aumento da frequ√™ncia de sensibiliza√ß√£o ao grupo dos √°caros dom√©sticos, bem como a altera√ß√£o dos tipos pol√≠nicos respons√°veis pelas maiores frequ√™ncias de sensibiliza√ß√£oABSTRACT - SENSITIZATION PATTERNS OF DOGS WITH CANINE ATOPIC DERMATITIS IN LISBON METROPOLITAN AREA - Canine atopic dermatitis (CAD) is a pruritic, inflammatory and chronic skin disease that results from the interaction between genetic and environmental factors and can be the result of the hypersensitization to environmental allergens (non-food-induced atopic dermatitis - NFIAD). The diagnosis of NFIAD is achieved by excluding other entities with the same clinical signs, followed by the identification of allergens to which the dog sensitized, mostly through intradermal testing (IDT) or serological allergen testing (SAT). The main objective of this study was to identify the frequency of sensitization to different allergens within a canine population and comparing it with previously reported data. In this study were included dogs living in the Lisbon Metropolitan Area that did an IDT at the Dermatology Department of the Veterinary Teaching Hospital (HEV), between the years 2012 and 2017, as well as dogs that did a SAT through an external laboratory from 2019 to 2022. A total of 257 dogs underwent allergy testing, of which 13.23% (n=34) were negative. Thus, 223 dogs with positive results were admitted to the study, 118 using IDT and 105 using SAT. The allergen group with the highest frequency of sensitization was mites, with 86.44% in the IDTs and 87.62% in the SATs. In this group, positivity to two or more mites occurred in more than 92% of the individuals, with sensitization to three mites being the most frequent situation (29.38%), followed by positivity to all five mites (28.35%). Dermatophagoides farinae recorded the highest individual frequency in IDTs (75.42%) and SATs (74.29%). The pollen group was the second with the highest frequency of sensitizations (44.07% in IDTs and 30.48% in SATs). Within this group, the pollen type with the highest frequency of sensitization was grass which showed 29.66% in the IDTs and 21.9% in the SATs. The pollen of Festuca pratensis in the IDTs (12.71%) and Cynodon dactylon (16.19%) in the SATs, recorded the highest frequencies. The fungi group showed a sensitization frequency of 25.42% in IDTs and 24.76% in SATs, with Malassezia pachydermatis standing out (22.03% in IDTs and 16.19% in SATs). By comparing these results with previously published data, new patterns of canine sensitization were identified, being this the first study to investigate it during the mentioned period. An increase in the frequency of sensitization in the mite group was observed, as well as a change in pollen types responsible for the highest frequency of sensitizationsN/

    FATORES DE RISCO PARA O DESENVOLVIMENTO DE LESÃO POR PRESSÃO EM PACIENTES EM UNIDADE DE TERAPIA INTENSIVA

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    The present study aims to evaluate, through bibliographic survey, the risk of Pressure Injury (PPI) in patients admitted to Intensive Care Units (ICU), identifying their related risks and analyzing the main prevention measures and the importance of nursing care. Qualitative descriptive study whose instrument used for its preparation was a literature review, seeking to achieve the proposed objective. PPI is characterized by a change in the skin, usually near regions of bony prominence, where pressure occurs that has not been attenuated. The development of the injury occurs through critical etiological determinants, such as the intensity and duration of the Research, Society and Development, v. , n. e. , 2022 (CC BY ) | ISSN  | DOI:   pressure associated with the tolerance of the tissues to withstand certain pressure exerted. The risk factors are: impaired mobility and activity, sensory perception, factors that reduce tissue tolerance (extrinsic and intrinsic). Prevention is a challenge for the whole team and an indispensable care, because of the work required and the high costs to deal with the consequences of the onset. The nursing team relies on some risk assessment tools for prevention, such as the Braden scale, which helps to identify the patient at risk and also the risk factors that are associated, helping in decision making for the planning of individualized preventive measures. It is important to conduct new studies on the subject to help in the prevention and treatment of PPI, thus encouraging the search for new research, always aiming to inform about the proper updates on the subject, bringing benefits to readers in search of innovation, and health itself.O presente estudo tem como objetivo avaliar atrav√©s de levantamento bibliogr√°fico o risco de Les√£o Por Press√£o (LPP) em pacientes internados nas Unidades de Terapia Intensiva (UTI), identificando seus riscos relacionados e analisando as principais medidas de preven√ß√£o e a import√Ęncia da assist√™ncia de enfermagem.  Estudo qualitativo de car√°ter descritivo cujo instrumento utilizado para sua elabora√ß√£o foi uma revis√£o de literatura, buscando atingir ao objetivo proposto. A LPP √© caracterizada por altera√ß√£o na pele, normalmente pr√≥xima a regi√Ķes de proemin√™ncias √≥sseas, onde ocorre uma press√£o que n√£o foi atenuada. O desenvolvimento da les√£o se d√° por interm√©dio de determinantes etiol√≥gicos cr√≠ticos, como a intensidade e a dura√ß√£o da press√£o associada a toler√Ęncia dos tecidos para suportar determinada press√£o exercida. Os fatores de riscos s√£o: Mobilidade e atividade comprometida, percep√ß√£o sensorial, fatores que reduzem a toler√Ęncia tissular (extr√≠nsecos e intr√≠nsecos). A preven√ß√£o √© um desafio para toda a equipe e um cuidado indispens√°vel, devido ao trabalho necess√°rio e os altos custos para lidar com as consequ√™ncias do surgimento. A equipe de enfermagem conta na preven√ß√£o com alguns instrumentos de avalia√ß√£o de risco como a escala de Braden que ajuda a identificar o paciente em risco e tamb√©m os fatores de risco que est√£o associados auxiliando na tomada de decis√Ķes para o planejamento das medidas preventivas individualizadas. √Č importante a realiza√ß√£o de novos estudos sobre o tema para ajudar na preven√ß√£o e tratamento de LPP, assim incentivando a busca de novas pesquisas, com intuito sempre de informar sobre as devidas atualiza√ß√Ķes do determinado assunto, trazendo benef√≠cios para os leitores em busca de inova√ß√£o, e da sa√ļde em si

    Detec√ß√£o de casos e educa√ß√£o em sa√ļde relacionada √† hansen√≠ase em uma regi√£o end√™mica: um relato de experi√™ncia

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    Leprosy is considered a public health challenge. Its persistent presence in certain regions demands innovative approaches focused on awareness, detection, and treatment. In this scenario, the present study aims to describe an experience focused on leprosy detection and education in a region endemic for this disease. This is a qualitative study structured as an experience report, carried out from the experiences lived by four professors with training in the health area, when developing the project ‚ÄúRoda-Hans/Carreta da Sa√ļde ‚Äď Hansen√≠ase‚ÄĚ, during its passage through the municipality of Paulo Afonso, Bahia. In total, 26 health professionals were involved in the 93 consultations performed. Of these, 11 (11.8%) individuals were diagnosed with leprosy. During the training and care actions, a significant interaction was observed between different professionals and health sectors, promoting knowledge and fostering cooperative and collaborative learning in the identification of new cases. Also noteworthy is the commitment of health professionals, the exchange of experiences, as well as the consolidation of a leprosy assistance network in Primary Health Care (PHC). The actions resulting from the arrival of the mobile health unit in the municipality enabled the identification of hidden cases in the region, as well as the expansion and strengthening of partnerships among healthcare services, educational institutions, and the reference facility. Ultimately, the training and discussions promoted an enhancement of diagnostic, treatment, and prevention skills within the PHC.A hansen√≠ase emerge como um desafio √† sa√ļde p√ļblica. Sua persistente presen√ßa em determinadas regi√Ķes exige abordagens inovadoras e voltadas para a conscientiza√ß√£o, detec√ß√£o e tratamento. Neste contexto, o presente estudo tem por objetivo descrever uma experi√™ncia na detec√ß√£o e na educa√ß√£o relacionadas √† hansen√≠ase em uma regi√£o end√™mica. Trata-se de um estudo de abordagem qualitativa, do tipo relato de experi√™ncia, realizado a partir da viv√™ncia experenciada por quatro docentes com forma√ß√£o na √°rea da sa√ļde, ao desenvolver o projeto ‚ÄúRoda Hans/Carreta da Sa√ļde ‚Äď HanseniŐĀase‚ÄĚ, durante a sua passagem pelo munic√≠pio de Paulo Afonso, Bahia. Ao todo, 26 profissionais da sa√ļde estiveram envolvidos nos 93 atendimentos realizados, dentre os quais 11 (11,8%) indiv√≠duos assistidos foram diagnosticados com hansen√≠ase. Percebeu-se, durante as a√ß√Ķes de capacita√ß√£o e de atendimento, uma maior intera√ß√£o entre diferentes profissionais e setores de sa√ļde, ao promoverem conhecimento e ao fomentarem uma aprendizagem cooperativa e colaborativa na identifica√ß√£o dos novos casos. Destaca-se, ainda, o comprometimento dos profissionais de sa√ļde, a troca de experi√™ncias e viv√™ncias, bem como a consolida√ß√£o de uma rede de assist√™ncia √† hansen√≠ase na Aten√ß√£o Prim√°ria √† Sa√ļde (APS). As a√ß√Ķes advindas da chegada da carreta ao munic√≠pio possibilitaram a identifica√ß√£o de casos ocultos na regi√£o, a amplia√ß√£o e o fortalecimento das parcerias entre os servi√ßos de sa√ļde, as institui√ß√Ķes de ensino e o servi√ßo de refer√™ncia. Por fim, a capacita√ß√£o e as discuss√Ķes promoveram um aprimoramento das habilidades de diagn√≥stico, bem como de tratamento e de preven√ß√£o na APS
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