5,906 research outputs found
Flow rate of transport network controls uniform metabolite supply to tissue
Life and functioning of higher organisms depends on the continuous supply of
metabolites to tissues and organs. What are the requirements on the transport
network pervading a tissue to provide a uniform supply of nutrients, minerals,
or hormones? To theoretically answer this question, we present an analytical
scaling argument and numerical simulations on how flow dynamics and network
architecture control active spread and uniform supply of metabolites by
studying the example of xylem vessels in plants. We identify the fluid inflow
rate as the key factor for uniform supply. While at low inflow rates
metabolites are already exhausted close to flow inlets, too high inflow flushes
metabolites through the network and deprives tissue close to inlets of supply.
In between these two regimes, there exists an optimal inflow rate that yields a
uniform supply of metabolites. We determine this optimal inflow analytically in
quantitative agreement with numerical results. Optimizing network architecture
by reducing the supply variance over all network tubes, we identify patterns of
tube dilation or contraction that compensate sub-optimal supply for the case of
too low or too high inflow rate.Comment: 11 pages, 4 figures, 8 pages supplemen
The Expenditure Impacts of London-based Individual Higher Education Institutions (HEIs) and their Students on the Economy of England : Homogeneity or Heterogeneity?
This paper replicates the analysis of Scottish HEIs in Hermannsson et al (2010a) to identify the impact of London-based HEIs on the English economy in order to provide a self-contained analysis that is readily accessible by those whose primary concern is with the regional impacts of London HEIs. When we treat each of the 38 London-based Higher Education Institutions (HEIs) that existed in England in 2006 as separate sectors in conventional input-output analysis, their expenditure impacts per unit of final demand appear rather homogenous (though less so than HEIs in Wales and Scotland), with the apparent heterogeneity of their overall impacts being primarily driven by scale. However, a disaggregation of their income by source reveals considerable variation in their dependence upon general public funding and their ability to draw in income/funding from external sources. Acknowledging the possible alternative uses of the public funding and deriving balanced expenditure multipliers reveals large differences in the net-expenditure impact of London HEIs upon the English economy, with the source of variation being the origin of income. Applying a novel treatment of student expenditure impacts, identifying the amount of exogenous spending per student, modifies the heterogeneity of the overall expenditure impacts. On balance this suggests that the impacts of impending budget cut-backs will be quite different by institution depending on their sensitivity to public funding. However, predicting the outcome of budget cutbacks at the margin is problematic for reasons that we identify
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