High functional coherence in k-partite protein cliques of protein interaction networks

We introduce a new topological concept called k-partite protein cliques to study protein interaction (PPI) networks. In particular, we examine functional coherence of proteins in k-partite protein cliques. A k-partite protein clique is a k-partite maximal clique comprising two or more nonoverlapping protein subsets between any two of which full interactions are exhibited. In the detection of PPI&rsquo;s k-partite maximal cliques, we propose to transform PPI networks into induced K-partite graphs with proteins as vertices where edges only exist among the graph&rsquo;s partites. Then, we present a k-partite maximal clique mining (MaCMik) algorithm to enumerate k-partite maximal cliques from K-partite graphs. Our MaCMik algorithm is applied to a yeast PPI network. We observe that there does exist interesting and unusually high functional coherence in k-partite protein cliques&mdash;most proteins in k-partite protein cliques, especially those in the same partites, share the same functions. Therefore, the idea of k-partite protein cliques suggests a novel approach to characterizing PPI networks, and may help function prediction for unknown proteins.<br /

Finding events in temporal networks: Segmentation meets densest-subgraph discovery

International audienceIn this paper we study the problem of discovering a timeline of events in a temporal network. We model events as dense subgraphs that occur within intervals of network activity. We formulate the event-discovery task as an optimization problem, where we search for a partition of the network timeline into k non-overlapping intervals, such that the intervals span subgraphs with maximum total density. The output is a sequence of dense subgraphs along with corresponding time intervals, capturing the most interesting events during the network lifetime. A naïve solution to our optimization problem has polynomial but prohibitively high running time complexity. We adapt existing recent work on dynamic densest-subgraph discovery and approximate dynamic programming to design a fast approximation algorithm. Next, to ensure richer structure, we adjust the problem formulation to encourage coverage of a larger set of nodes. This problem is NP-hard even for static graphs. However, on static graphs a simple greedy algorithm leads to approximate solution due to submodularity. We extended this greedy approach for the case of temporal networks. However, the approximation guarantee does not hold. Nevertheless, according to the experiments, the algorithm finds good quality solutions