Monte Carlo-based Noise Compensation in Coil Intensity Corrected Endorectal MRI

Background: Prostate cancer is one of the most common forms of cancer found in males making early diagnosis important. Magnetic resonance imaging (MRI) has been useful in visualizing and localizing tumor candidates and with the use of endorectal coils (ERC), the signal-to-noise ratio (SNR) can be improved. The coils introduce intensity inhomogeneities and the surface coil intensity correction built into MRI scanners is used to reduce these inhomogeneities. However, the correction typically performed at the MRI scanner level leads to noise amplification and noise level variations. Methods: In this study, we introduce a new Monte Carlo-based noise compensation approach for coil intensity corrected endorectal MRI which allows for effective noise compensation and preservation of details within the prostate. The approach accounts for the ERC SNR profile via a spatially-adaptive noise model for correcting non-stationary noise variations. Such a method is useful particularly for improving the image quality of coil intensity corrected endorectal MRI data performed at the MRI scanner level and when the original raw data is not available. Results: SNR and contrast-to-noise ratio (CNR) analysis in patient experiments demonstrate an average improvement of 11.7 dB and 11.2 dB respectively over uncorrected endorectal MRI, and provides strong performance when compared to existing approaches. Conclusions: A new noise compensation method was developed for the purpose of improving the quality of coil intensity corrected endorectal MRI data performed at the MRI scanner level. We illustrate that promising noise compensation performance can be achieved for the proposed approach, which is particularly important for processing coil intensity corrected endorectal MRI data performed at the MRI scanner level and when the original raw data is not available.Comment: 23 page

Off-the-Grid Line Spectrum Denoising and Estimation with Multiple Measurement Vectors

Compressed Sensing suggests that the required number of samples for reconstructing a signal can be greatly reduced if it is sparse in a known discrete basis, yet many real-world signals are sparse in a continuous dictionary. One example is the spectrally-sparse signal, which is composed of a small number of spectral atoms with arbitrary frequencies on the unit interval. In this paper we study the problem of line spectrum denoising and estimation with an ensemble of spectrally-sparse signals composed of the same set of continuous-valued frequencies from their partial and noisy observations. Two approaches are developed based on atomic norm minimization and structured covariance estimation, both of which can be solved efficiently via semidefinite programming. The first approach aims to estimate and denoise the set of signals from their partial and noisy observations via atomic norm minimization, and recover the frequencies via examining the dual polynomial of the convex program. We characterize the optimality condition of the proposed algorithm and derive the expected convergence rate for denoising, demonstrating the benefit of including multiple measurement vectors. The second approach aims to recover the population covariance matrix from the partially observed sample covariance matrix by motivating its low-rank Toeplitz structure without recovering the signal ensemble. Performance guarantee is derived with a finite number of measurement vectors. The frequencies can be recovered via conventional spectrum estimation methods such as MUSIC from the estimated covariance matrix. Finally, numerical examples are provided to validate the favorable performance of the proposed algorithms, with comparisons against several existing approaches.Comment: 14 pages, 10 figure

Hierarchical Bayesian sparse image reconstruction with application to MRFM

This paper presents a hierarchical Bayesian model to reconstruct sparse images when the observations are obtained from linear transformations and corrupted by an additive white Gaussian noise. Our hierarchical Bayes model is well suited to such naturally sparse image applications as it seamlessly accounts for properties such as sparsity and positivity of the image via appropriate Bayes priors. We propose a prior that is based on a weighted mixture of a positive exponential distribution and a mass at zero. The prior has hyperparameters that are tuned automatically by marginalization over the hierarchical Bayesian model. To overcome the complexity of the posterior distribution, a Gibbs sampling strategy is proposed. The Gibbs samples can be used to estimate the image to be recovered, e.g. by maximizing the estimated posterior distribution. In our fully Bayesian approach the posteriors of all the parameters are available. Thus our algorithm provides more information than other previously proposed sparse reconstruction methods that only give a point estimate. The performance of our hierarchical Bayesian sparse reconstruction method is illustrated on synthetic and real data collected from a tobacco virus sample using a prototype MRFM instrument.Comment: v2: final version; IEEE Trans. Image Processing, 200