Demixed principal component analysis of neural population data

Neurons in higher cortical areas, such as the prefrontal cortex, are often tuned to a variety of sensory and motor variables, and are therefore said to display mixed selectivity. This complexity of single neuron responses can obscure what information these areas represent and how it is represented. Here we demonstrate the advantages of a new dimensionality reduction technique, demixed principal component analysis (dPCA), that decomposes population activity into a few components. In addition to systematically capturing the majority of the variance of the data, dPCA also exposes the dependence of the neural representation on task parameters such as stimuli, decisions, or rewards. To illustrate our method we reanalyze population data from four datasets comprising different species, different cortical areas and different experimental tasks. In each case, dPCA provides a concise way of visualizing the data that summarizes the task-dependent features of the population response in a single figure

Convexity in source separation: Models, geometry, and algorithms

Source separation or demixing is the process of extracting multiple components entangled within a signal. Contemporary signal processing presents a host of difficult source separation problems, from interference cancellation to background subtraction, blind deconvolution, and even dictionary learning. Despite the recent progress in each of these applications, advances in high-throughput sensor technology place demixing algorithms under pressure to accommodate extremely high-dimensional signals, separate an ever larger number of sources, and cope with more sophisticated signal and mixing models. These difficulties are exacerbated by the need for real-time action in automated decision-making systems. Recent advances in convex optimization provide a simple framework for efficiently solving numerous difficult demixing problems. This article provides an overview of the emerging field, explains the theory that governs the underlying procedures, and surveys algorithms that solve them efficiently. We aim to equip practitioners with a toolkit for constructing their own demixing algorithms that work, as well as concrete intuition for why they work