Performance assessment of low-cost thermal cameras for medical applications

Thermal imaging is a promising technology in the medical field. Recent developments in low-cost infrared (IR) sensors, compatible with smartphones, provide competitive advantages for home-monitoring applications. However, these sensors present reduced capabilities compared to more expensive high-end devices. In this work, the characterization of thermal cameras is described and carried out. This characterization includes non-uniformity (NU) effects and correction as well as the thermal cameras´ dependence on room temperature, noise-equivalent temperature difference (NETD), and response curve stability with temperature. Results show that low-cost thermal cameras offer good performance, especially when used in temperature-controlled environments, providing evidence of the suitability of such sensors for medical applications, particularly in the assessment of diabetic foot ulcers on which we focused this study.This research was funded by the IACTEC Technological Training program, grant number TF INNOVA 2016-2021, and by the European Union Interreg-Mac funding program, grant number MAC/1.1.b/098 (MACbioIDi project)

Imaging Sensors and Applications

In past decades, various sensor technologies have been used in all areas of our lives, thus improving our quality of life. In particular, imaging sensors have been widely applied in the development of various imaging approaches such as optical imaging, ultrasound imaging, X-ray imaging, and nuclear imaging, and contributed to achieve high sensitivity, miniaturization, and real-time imaging. These advanced image sensing technologies play an important role not only in the medical field but also in the industrial field. This Special Issue covers broad topics on imaging sensors and applications. The scope range of imaging sensors can be extended to novel imaging sensors and diverse imaging systems, including hardware and software advancements. Additionally, biomedical and nondestructive sensing applications are welcome

Imaging White Blood Cells using a Snapshot Hyper-Spectral Imaging System

Automated white blood cell (WBC) counting systems process an extracted whole blood sample and provide a cell count. A step that would not be ideal for onsite screening of individuals in triage or at a security gate. Snapshot Hyper-Spectral imaging systems are capable of capturing several spectral bands simultaneously, offering co-registered images of a target. With appropriate optics, these systems are potentially able to image blood cells in vivo as they flow through a vessel, eliminating the need for a blood draw and sample staining. Our group has evaluated the capability of a commercial Snapshot Hyper-Spectral imaging system, specifically the Arrow system from Rebellion Photonics, in differentiating between white and red blood cells on unstained and sealed blood smear slides. We evaluated the imaging capabilities of this hyperspectral camera as a platform to build an automated blood cell counting system. Hyperspectral data consisting of 25, 443x313 hyperspectral bands with ~3nm spacing were captured over the range of 419 to 494nm. Open-source hyperspectral datacube analysis tools, used primarily in Geographic Information Systems (GIS) applications, indicate that white blood cells\u27 features are most prominent in the 428-442nm band for blood samples viewed under 20x and 50x magnification over a varying range of illumination intensities. The system has shown to successfully segment blood cells based on their spectral-spatial information. These images could potentially be used in subsequent automated white blood cell segmentation and counting algorithms for performing in vivo white blood cell counting

Application of artificial intelligence techniques to the smart control of sheet metal forming processes

The present research work aims at evaluating the economical feasibility and the technological viability of implementing intelligent control systems in complex industrial manufacturing processes; in this case forming processes. Forming processes are manufacturing processes that use force and pressure in order to modify the shape of a material part until getting the final product. The wide range of non-linear factors (material properties, tool geometry, machine parameters and lubrication variables) that determine the final quality of the parts manufactured by these processes makes them to be inherently quite unstable. Thus, the control made by human operators is still essential nowadays. On the other hand, although human operators have demonstrated to be a very successful strategy when controlling this type of processes, the actual market evolution towards the fabrication of more complex parts, made of lower formability materials at higher production rates is decreasing their capacity of reaction when solving the daily problems. Therefore, the development of new automatic and global control systems based, not on traditional control techniques and mathematical models but on the control strategy that has been successfully used for many years, the control through the experience and knowledge, is now even more necessary. In the present research work, two intelligent control systems based on AI techniques have been developed and evaluated. The main purpose of these intelligent control systems is to identify the process failures at forming processes and to propose the right solutions that should lead to their solution, all this in a quick and reliable way. Following this strategy, the solution of the process failures is considerably simplified because, after any process failure of defective part detection, human operators find a report where an explanation of the incidence, as well as its causes and the way to solve it, are displayed. This has the inherent advantage of decreasing the length of the downtimes at the manufacturing facilities and thus increasing the number of parts produced. Together with the previously described core of the global control systems, two monitoring systems have been developed and implemented in a forming facility too. The purpose of these monitoring systems is to work as the senses of the intelligent control systems. The first one, an artificial vision system, is aimed at evaluating the quality of the produced parts by carrying out a 100% quality control at the end of the forming process. This will assure the right quality of all the products shipped to the customer. The second one, a sensors based process monitoring system, is aimed at detecting any process failure at the forming facility by means of force and acoustic emissions measurements. This will reduce the internal defective and will assure the security of the forming facility. Both systems are in charge of detecting any process failure and defective part and of reporting about them to the intelligent control system. Since the aim of the research work was to evaluate the feasibility of implementing global intelligent control systems in the industry, all the developments and results achieved through the present research work have been carried out in an industrial environment. The research work is principally divided into three main parts; 1) the development and implementation of the sensors based process monitoring system, 2) the development and implementation of the AV monitoring system and 3) the development of the intelligent control systems. At the end, a summary of all the results and conclusions achieved through the development of the previous mentioned systems is given too.Ikerkuntza lan honen helburua sistema adimendunak fabrikazio prozesu konplexuak kontrolatzeko erabiltzearen bideragarritasuna aztertzea da, bai ekonomikoki eta teknologikoki. Kasu honetan, konformazio prozesuetan inplementatutako sistema adimenduak ikertu dira. Konformazio prozesuak, amaierako produktua lortzeko, hasierako materialari esfortzu edo presioen bidez forma geometrikoa aldatzean datzate. Konformaturiko piezen amaierako kalitatea finkatzen duten aldagai ez-linealen ugaritasun zabalak (materialen propietateak, lanabesen geometriak, makinen parametroak eta/edo lubrifikazioa) prozesu hauek ezegonkorrak izatea ondorioztatzen du. Hori dela medio, gaur egun ere, prozesu hauen kontrola giza-langile bidez egiten da. Langileak prozesu hauek modu eraginkorrean kontrolatzeko gai direla erakutsi du esperientziak. Dena den, deformagarritasun txikiagoko materialez eginiko pieza konplexuagoak kadentzia altuagoetan fabrikatzeko gaur egungo joerak, langileek ezustekoen aurrean erantzuteko duten gaitasuna gutxitu du. Ondorioz, prozesua gainbegiratu eta kontrolatzen duten sistema automatiko eta adimendu berrien garapena beharrezkoa bihurtu da. Sistema hauek ez daude kontrol teknika tradizional edo eredu matematikoetan oinarrituak. Sistema hauen kontrola ezagutza eta esperientzian oinarriturik dago, zeinak azken urteetan emaitza onak eman dituen. Ikerkuntza lan honetan adimen artifizial tekniketan oinarrituriko bi kontrol sistema adimendun garatu eta baloratu dira. Sistema hauen helburu nagusia konformazio prozesuetan emaniko akatsak identifikatu eta automatikoki ebazpenproposamenak aurkeztea da, modu azkar eta sendoan. Estrategia hau jarraituz, prozesuko akatsen ebazpena errazten da, pieza akastunak atzematean edo makinaren geldialdi baten aurrean, sistemak langilea eman beharreko pausuak azaltzen dizkion txosten batez hornituko baitu. Makinaren geldialdiaren murriztea eta ondorioz, produktibitatea igotzea da honen abantaila nagusia, akatsen identifikazioa berehalakoa baita. Kontrol sistema garatzeaz gain, puntzonaketa instalakuntza batean bi monitorizazio sistema martxan jarri dira. Bi monitorizazio sistema hauen helburua prozesuaren informazioa jaso eta kontrol sistemari bidaltzea da. Lehenengoa ikuspen artifizialeko sistema bat da, zeinaren helburua ekoiztutako piezen %100aren kalitatea aztertzea den. Honenbestez, bezeroei bidalitako piezen kalitate egokia bermatzen da. Bigarrena sentsoreetan oinarrituriko prozesuen monitorizazio sistema bat da. Bere helburua prozesuan emaniko edozein akats antzematea da. Honek akastun piezen kantitatea gutxitzen du eta instalakuntzak prozesuen ezegonkortasunetatik babesten ditu. Ondorioz, bi sistemen helburua prozesuan izandako arazo edo pieza akastunak antzematea eta kontrol sistemari hauen berri ematea da. Lan honen helburua aurrez aipaturiko sistemen gaitasuna industri ingurunean ebaluatzea denez, aurkezturiko garapen eta emaitzak enpresa batean burutu dira. Hiru atal nagusi bereiz daitezke lan honetan: 1) sentsoreetan oinarrituriko monitorizazio sistema baten garapen eta inplementazioa; 2) ikuskapen artifizialeko sistemaren garapen eta inplementazioa; eta 3) adimendun kontrolean oinarrituriko sistemen garapena.El presente trabajo de investigación tiene como objetivo evaluar en qué condiciones es económicamente viable y tecnológicamente factible la implementación de sistemas inteligentes de control en procesos de fabricación complejos; en este caso procesos de conformado. Los procesos de conformado son procesos de fabricación basados en la aplicación de esfuerzos o presiones sobre componentes con el objetivo de modificar su forma geométrica hasta conseguir un producto final. El gran abanico de variables no lineales (propiedades de materiales, geometría de herramientas, parámetros de máquinas y/o lubricación) que determinan la calidad final de las piezas conformadas hacen que estos procesos sean inherentemente inestables. Por ello, aun hoy en día, el control de estos procesos se realiza mediante operarios humanos. Por otro lado, aunque la experiencia ha demostrado que los operarios son capaces de controlar estos procesos de manera eficiente, la actual tendencia hacia la fabricación de piezas más complejas, fabricadas en materiales menos deformables y todo ello a cadencias de fabricación mayores, ha hecho que la capacidad de los operarios para reaccionar ante imprevistos se haya visto mermada. Por lo tanto, el desarrollo de nuevos sistemas automáticos e inteligentes de supervisión y control basados, no en técnicas tradicionales de control o en modelos matemáticos, sino en la estrategia de control que ha dado buenos resultados a lo largo de los años, el control basado en la experiencia y el conocimiento, es cada vez más necesario. En el presente trabajo de investigación, se han desarrollado y evaluado dos sistemas inteligentes de control basados en técnicas de inteligencia artificial. El principal objetivo de estos sistemas es ser capaces de identificar los fallos de proceso en procesos de conformado así como de plantear, automáticamente, las instrucciones para su resolución, todo ello de una manera rápida y robusta. Siguiendo esta estrategia, la resolución de los fallos de proceso se simplifica ya que, tras una parada de máquina o la detección de piezas defectuosas, el sistema proporciona al operario un informe donde se detallan las acciones a llevar a cabo. Esto tiene como ventaja una reducción en los tiempos de parada de máquina (y por lo tanto aumento en la cantidad de piezas producidas) ya que la identificación de los fallos es inmediata. Junto con el núcleo del sistema global de control, se han desarrollado e implementando en una instalación de corte progresivo dos sistemas de monitorización. El objetivo de estos dos sistemas de monitorización es recoger información sobre el proceso y enviársela al sistema de control. El primero, un sistema de visión artificial, tiene como objetivo analizar la calidad del 100% de las piezas fabricadas. Esto asegura la correcta calidad de todas las piezas enviadas a los clientes. El segundo, un sistema de monitorización de procesos basado en sensores, tiene como objetivo la detección de cualquier fallo de proceso. Esto reduce el defectivo interno y protege a las instalaciones frente a anomalías de proceso. Por lo tanto, ambos sistemas tienen como misión la detección de cualquier anomalía de proceso o pieza defectiva así como informar al sistema de control sobre las mismas. Puesto que el objetivo de este trabajo es evaluar la capacidad de los sistemas anteriormente citados en el entorno industrial, todos los desarrollos y resultados obtenidos a lo largo del mismo se han llevado a cabo en una empresa. El trabajo se puede dividir en tres partes: 1) el desarrollo e implementación del sistema de monitorización basado en sensores, 2) el desarrollo e implementación del sistema de visión artificial y 3) el desarrollo de los sistemas de control inteligentes

30th International Conference on Condition Monitoring and Diagnostic Engineering Management (COMADEM 2017)

Proceedings of COMADEM 201

Design of a wearable LED-based phototherapy device

This thesis was previously held under moratorium from 23/03/2021 to 23/03/2022The aim of the work described in this thesis is to design a wearable phototherapy device utilising LEDs. Phototherapy is the use of light to treat medical conditions, such as, eczema, psoriasis and newborn jaundice. Treatment usually takes place in a clinical environment, but a recent focus for phototherapy is the development of at-home devices. Currently available technologies consist of rigid LED arrays; identifying the treatment regime with these devices is diffcult due to the non-uniform light distribution. A poten-tial solution to this problem is to create a flexible and conformable device that allows for uniform light distribution over the treatment area by incorporating light scattering features. Broad area LEDs (UV and blue) and blue micro-sized LEDs are utilised as the light source coupled into the end of a thin polydimethylsiloxane membrane. High refractive index nanoparticles are embedded in a substrate and used to extract light from the surface of the membrane. By changing the size of these substrates, or by changing the nanoparticle concentration inside the substrates, uniform irradiance is demonstrated over an area of 15 x 15 mm2. Though not demonstrated in this thesis, there is potential for treatment over larger areas. Colloidal quantum dots can be embedded in elastomeric materials and used to down-convert the LED light into lower energy wavelengths. This is shown with red wavelength emitting quantum dots, producing a uniform red irradiance over the substrate area. A similar technique is shown to produce multi-wavelength blue and red uniform emission over the extraction area. The output of the device can be optimised by adding flexible reflective layers to one side of the membrane. This increases the light output from the extraction substrates, whilst maintaining the device flexibility. The light output can also be increased by adding secondary embedded waveguides into the membrane. These are coupled to the micro-LED light and can potentially produce structured emission over the treatment area. The device platform is also shown to be effective as a fluorescent evanescent waveguide sensor, utilising quantum dots as the fluorescent molecules and a smart phone camera to measure the fluorescence.The aim of the work described in this thesis is to design a wearable phototherapy device utilising LEDs. Phototherapy is the use of light to treat medical conditions, such as, eczema, psoriasis and newborn jaundice. Treatment usually takes place in a clinical environment, but a recent focus for phototherapy is the development of at-home devices. Currently available technologies consist of rigid LED arrays; identifying the treatment regime with these devices is diffcult due to the non-uniform light distribution. A poten-tial solution to this problem is to create a flexible and conformable device that allows for uniform light distribution over the treatment area by incorporating light scattering features. Broad area LEDs (UV and blue) and blue micro-sized LEDs are utilised as the light source coupled into the end of a thin polydimethylsiloxane membrane. High refractive index nanoparticles are embedded in a substrate and used to extract light from the surface of the membrane. By changing the size of these substrates, or by changing the nanoparticle concentration inside the substrates, uniform irradiance is demonstrated over an area of 15 x 15 mm2. Though not demonstrated in this thesis, there is potential for treatment over larger areas. Colloidal quantum dots can be embedded in elastomeric materials and used to down-convert the LED light into lower energy wavelengths. This is shown with red wavelength emitting quantum dots, producing a uniform red irradiance over the substrate area. A similar technique is shown to produce multi-wavelength blue and red uniform emission over the extraction area. The output of the device can be optimised by adding flexible reflective layers to one side of the membrane. This increases the light output from the extraction substrates, whilst maintaining the device flexibility. The light output can also be increased by adding secondary embedded waveguides into the membrane. These are coupled to the micro-LED light and can potentially produce structured emission over the treatment area. The device platform is also shown to be effective as a fluorescent evanescent waveguide sensor, utilising quantum dots as the fluorescent molecules and a smart phone camera to measure the fluorescence

Intelligent Computing in Medical Ultrasonic System

兵庫県立大学大学院201

Contributions to the improvement of image quality in CBCT and CBμCT and application in the development of a CBμCT system

During the last years cone-beam x-ray CT (CBCT) has been established as a widespread imaging technique and a feasible alternative to conventional CT for dedicated imaging tasks for which the limited flexibility offered by conventional CT advises the development of dedicated designs. CBCT systems are starting to be routinely used in image guided radiotherapy; image guided surgery using C-arms; scan of body parts such as the sinuses, the breast or extremities; and, especially, in preclinical small-animal imaging, often coupled to molecular imaging systems. Despite the research efforts advocated to the advance of CBCT, the challenges introduced by the use of large cone angles and two-dimensional detectors are a field of vigorous research towards the improvement of CBCT image quality. Moreover, systems for small-animal imaging add to the challenges posed by clinical CBCT the need of higher resolution to obtain equivalent image quality in much smaller subjects. This thesis contributes to the progress of CBCT imaging by addressing a variety of issues affecting image quality in CBCT in general and in CBCT for small-animal imaging (CBμCT). As part of this work we have assessed and optimized the performance of CBμCT systems for different imaging tasks. To this end, we have developed a new CBμCT system with variable geometry and all the required software tools for acquisition, calibration and reconstruction. The system served as a tool for the optimization of the imaging process and for the study of image degradation effects in CBμCT, as well as a platform for biological research using small animals. The set of tools for the accurate study of CBCT was completed by developing a fast Monte Carlo simulation engine based on GPUs, specifically devoted to the realistic estimation of scatter and its effects on image quality in arbitrary CBCT configurations, with arbitrary spectra, detector response, and antiscatter grids. This new Monte Carlo engine outperformed current simulation platforms by more than an order of magnitude. Due to the limited options for simulation of spectra in microfocus x-ray sources used in CBμCT, we contributed in this thesis a new spectra generation model based on an empirical model for conventional radiology and mammography sources modified in accordance to experimental data. The new spectral model showed good agreement with experimental exposure and attenuation data for different materials. The developed tools for CBμCT research were used for the study of detector performance in terms of dynamic range. The dynamic range of the detector was characterized together with its effect on image quality. As a result, a new simple method for the extension of the dynamic range of flat-panel detectors was proposed and evaluated. The method is based on a modified acquisition process and a mathematical treatment of the acquired data. Scatter is usually identified as one of the major causes of image quality degradation in CBCT. For this reason the developed Monte Carlo engine was applied to the in-depth study of the effects of scatter for a representative range of CBCT embodiments used in the clinical and preclinical practice. We estimated the amount and spatial distribution of the total scatter fluence and the individual components within. The effect of antiscatter grids in improving image quality and in noise was also evaluated. We found a close relation between scatter and the air gap of the system, in line with previous results in the literature. We also observed a non-negligible contribution of forward-directed scatter that is responsible to a great extent for streak artifacts in CBCT. The spatial distribution of scatter was significantly affected by forward scatter, somewhat challenging the usual assumption that the scatter distribution mostly contains low-frequencies. Antiscatter grids showed to be effective for the reduction of cupping, but they showed a much lower performance when dealing with streaks and a shift toward high frequencies of the scatter distributions. --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A lo largo de los últimos años, el TAC de rayos X de haz cónico (CBCT, de “conebeam” CT) se ha posicionado como una de las técnicas de imagen más ampliamente usadas. El CBCT se ha convertido en una alternativa factible al TAC convencional en tareas de imagen específicas para las que la flexibilidad limitada ofrecida por este hace recomendable el desarrollo de sistemas de imagen dedicados. De esta forma, el CBCT está empezando a usarse de forma rutinaria en varios campos entre los que se incluyen la radioterapia guiada por imagen, la cirugía guiada por imagen usando arcos en C, imagen de partes de la anatomía en las que el TAC convencional no es apropiado, como los senos nasales, las extremidades o la mama, y, especialmente el campo de imagen preclínica con pequeño animal. Los sistemas CBCT usados en este último campo se encuentran habitualmente combinados con sistemas de imagen molecular. A pesar del trabajo de investigación dedicado al avance de la técnica CBCT en los últimos años, los retos introducidos por el uso de haces cónicos y de detectores bidimensionales son un campo candente para la investigación médica, con el objetivo de obtener una calidad de imagen equivalente o superior a la proporcionada por el TAC convencional. En el caso de imagen preclínica, a los retos generados por el uso de CBCT se une la necesidad de una mayor resolución de imagen que permita observar estructuras anatómicas con el mismo nivel de detalle obtenido para humanos. Esta tesis contribuye al progreso del CBCT mediante el estudio de usa serie de efectos que afectan a la calidad de imagen de CBCT en general y en el ámbito preclínico en particular. Como parte de este trabajo, hemos evaluado y optimizado el rendimiento de sistemas CBCT preclínicos en función de la tarea de imagen concreta. Con este fin se ha desarrollado un sistema CBCT para pequeños animales con geometría variable y todas las herramientas necesarias para la adquisición, calibración y reconstrucción de imagen. El sistema sirve como base para la optimización de protocolos de adquisición y para el estudio de fuentes de degradación de imagen además de constituir una plataforma para la investigación biológica en pequeño animal. El conjunto de herramientas para el estudio del CBCT se completó con el desarrollo de una plataforma acelerada de simulación Monte Carlo basada en GPUs, optimizada para la estimación de radiación dispersa en CBCT y sus efectos en la calidad de imagen. La plataforma desarrollada supera el rendimiento de las actuales en más de un orden de magnitud y permite la inclusión de espectros policromáticos de rayos X, de la respuesta realista del detector y de rejillas antiscatter. Debido a las escasas opciones ofrecidas por la literatura para la estimación de espectros de rayos X para fuentes microfoco usadas en imagen preclínica, en esta tesis se incluye el desarrollo de un nuevo modelo de generación de espectros, basado en un modelo existente para fuentes usadas en radiología y mamografía. El modelo fue modificado a partir de datos experimentales. La precisión del modelo presentado se comprobó mediante datos experimentales de exposición y atenuación para varios materiales. Las herramientas desarrolladas se usaron para estudiar el rendimiento de detectores de rayos tipo flat-panel en términos de rango dinámico, explorando los límites impuestos por el mismo en la calidad de imagen. Como resultado se propuso y evaluó un método para la extensión del rango dinámico de este tipo de detectores. El método se basa en la modificación del proceso de adquisición de imagen y en una etapa de postproceso de los datos adquiridos. El simulador Monte Carlo se empleó para el estudio detallado de la naturaleza, distribución espacial y efectos de la radiación dispersa en un rango de sistemas CBCT que cubre el espectro de aplicaciones propuestas en el entorno clínico y preclínico. Durante el estudio se inspeccionó la cantidad y distribución espacial de radiación dispersa y de sus componentes individuales y el efecto causado por la inclusión de rejillas antiscatter en términos de mejora de calidad de imagen y de ruido en la imagen. La distribución de radiación dispersa mostró una acentuada relación con la distancia entre muestra y detector en el equipo, en línea con resultados publicados previamente por otros autores. También se encontró una influencia no despreciable de componentes de radiación dispersa con bajos ángulos de desviación, poniendo en tela de juicio la tradicional asunción que considera que la distribución espacial de la radiación dispersa está formada casi exclusivamente por componentes de muy baja frecuencia. Las rejillas antiscatter demostraron ser efectivas para la reducción del artefacto de cupping, pero su efectividad para tratar artefactos en forma de línea (principalmente formados por radiación dispersa con bajo ángulo de desviación) resultó mucho menor. La inclusión de estas rejillas también enfatiza las componentes de alta frecuencia de la distribución espacial de la radiación dispersa

Cyber Security and Critical Infrastructures

This book contains the manuscripts that were accepted for publication in the MDPI Special Topic "Cyber Security and Critical Infrastructure" after a rigorous peer-review process. Authors from academia, government and industry contributed their innovative solutions, consistent with the interdisciplinary nature of cybersecurity. The book contains 16 articles: an editorial explaining current challenges, innovative solutions, real-world experiences including critical infrastructure, 15 original papers that present state-of-the-art innovative solutions to attacks on critical systems, and a review of cloud, edge computing, and fog's security and privacy issues