What evidence does deep learning model use to classify Skin Lesions?

Melanoma is a type of skin cancer with the most rapidly increasing incidence. Early detection of melanoma using dermoscopy images significantly increases patients' survival rate. However, accurately classifying skin lesions by eye, especially in the early stage of melanoma, is extremely challenging for the dermatologists. Hence, the discovery of reliable biomarkers will be meaningful for melanoma diagnosis. Recent years, the value of deep learning empowered computer-assisted diagnose has been shown in biomedical imaging based decision making. However, much research focuses on improving disease detection accuracy but not exploring the evidence of pathology. In this paper, we propose a method to interpret the deep learning classification findings. Firstly, we propose an accurate neural network architecture to classify skin lesions. Secondly, we utilize a prediction difference analysis method that examines each patch on the image through patch-wised corrupting to detect the biomarkers. Lastly, we validate that our biomarker findings are corresponding to the patterns in the literature. The findings can be significant and useful to guide clinical diagnosis.Comment: 5 page

(De)Constructing Bias on Skin Lesion Datasets

Melanoma is the deadliest form of skin cancer. Automated skin lesion analysis plays an important role for early detection. Nowadays, the ISIC Archive and the Atlas of Dermoscopy dataset are the most employed skin lesion sources to benchmark deep-learning based tools. However, all datasets contain biases, often unintentional, due to how they were acquired and annotated. Those biases distort the performance of machine-learning models, creating spurious correlations that the models can unfairly exploit, or, contrarily destroying cogent correlations that the models could learn. In this paper, we propose a set of experiments that reveal both types of biases, positive and negative, in existing skin lesion datasets. Our results show that models can correctly classify skin lesion images without clinically-meaningful information: disturbingly, the machine-learning model learned over images where no information about the lesion remains, presents an accuracy above the AI benchmark curated with dermatologists' performances. That strongly suggests spurious correlations guiding the models. We fed models with additional clinically meaningful information, which failed to improve the results even slightly, suggesting the destruction of cogent correlations. Our main findings raise awareness of the limitations of models trained and evaluated in small datasets such as the ones we evaluated, and may suggest future guidelines for models intended for real-world deployment.Comment: 9 pages, 6 figures. Paper accepted at 2019 ISIC Skin Image Anaylsis Workshop @ IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops (CVPRW

A Deep Multi-task Learning Approach to Skin Lesion Classification

Skin lesion identification is a key step toward dermatological diagnosis. When describing a skin lesion, it is very important to note its body site distribution as many skin diseases commonly affect particular parts of the body. To exploit the correlation between skin lesions and their body site distributions, in this study, we investigate the possibility of improving skin lesion classification using the additional context information provided by body location. Specifically, we build a deep multi-task learning (MTL) framework to jointly optimize skin lesion classification and body location classification (the latter is used as an inductive bias). Our MTL framework uses the state-of-the-art ImageNet pretrained model with specialized loss functions for the two related tasks. Our experiments show that the proposed MTL based method performs more robustly than its standalone (single-task) counterpart.Comment: AAAI 2017 Joint Workshop on Health Intelligence W3PHIAI 2017 (W3PHI & HIAI), San Francisco, CA, 201

Classification of Dermoscopy Images using Deep Learning

Skin cancer is one of the most common forms of cancer and its incidence is projected to rise over the next decade. Artificial intelligence is a viable solution to the issue of providing quality care to patients in areas lacking access to trained dermatologists. Considerable progress has been made in the use of automated applications for accurate classification of skin lesions from digital images. In this manuscript, we discuss the design and implementation of a deep learning algorithm for classification of dermoscopy images from the HAM10000 Dataset. We trained a convolutional neural network based on the ResNet50 architecture to accurately classify dermoscopy images of skin lesions into one of seven disease categories. Using our custom model, we obtained a balanced accuracy of 91% on the validation dataset

Multi-class Semantic Segmentation of Skin Lesions via Fully Convolutional Networks

Melanoma is clinically difficult to distinguish from common benign skin lesions, particularly melanocytic naevus and seborrhoeic keratosis. The dermoscopic appearance of these lesions has huge intra-class variations and high inter-class visual similarities. Most current research is focusing on single-class segmentation irrespective of classes of skin lesions. In this work, we evaluate the performance of deep learning on multi-class segmentation of ISIC-2017 challenge dataset, which consists of 2,750 dermoscopic images. We propose an end-to-end solution using fully convolutional networks (FCNs) for multi-class semantic segmentation to automatically segment the melanoma, seborrhoeic keratosis and naevus. To improve the performance of FCNs, transfer learning and a hybrid loss function are used. We evaluate the performance of the deep learning segmentation methods for multi-class segmentation and lesion diagnosis (with post-processing method) on the testing set of the ISIC-2017 challenge dataset. The results showed that the two-tier level transfer learning FCN-8s achieved the overall best result with \textit{Dice} score of 78.5% in a naevus category, 65.3% in melanoma, and 55.7% in seborrhoeic keratosis in multi-class segmentation and Accuracy of 84.62% for recognition of melanoma in lesion diagnosis.Comment: Comp2clinic workshop at Biostec 202

Deep Learning for Skin Lesion Classification

Melanoma, a malignant form of skin cancer is very threatening to life. Diagnosis of melanoma at an earlier stage is highly needed as it has a very high cure rate. Benign and malignant forms of skin cancer can be detected by analyzing the lesions present on the surface of the skin using dermoscopic images. In this work, an automated skin lesion detection system has been developed which learns the representation of the image using Google's pretrained CNN model known as Inception-v3 \cite{cnn}. After obtaining the representation vector for our input dermoscopic images we have trained two layer feed forward neural network to classify the images as malignant or benign. The system also classifies the images based on the cause of the cancer either due to melanocytic or non-melanocytic cells using a different neural network. These classification tasks are part of the challenge organized by International Skin Imaging Collaboration (ISIC) 2017. Our system learns to classify the images based on the model built using the training images given in the challenge and the experimental results were evaluated using validation and test sets. Our system has achieved an overall accuracy of 65.8\% for the validation set.Comment: 3 pages with 3 figure

Multiple Abnormality Detection for Automatic Medical Image Diagnosis Using Bifurcated Convolutional Neural Network

Automating classification and segmentation process of abnormal regions in different body organs has a crucial role in most of medical imaging applications such as funduscopy, endoscopy, and dermoscopy. Detecting multiple abnormalities in each type of images is necessary for better and more accurate diagnosis procedure and medical decisions. In recent years portable medical imaging devices such as capsule endoscopy and digital dermatoscope have been introduced and made the diagnosis procedure easier and more efficient. However, these portable devices have constrained power resources and limited computational capability. To address this problem, we propose a bifurcated structure for convolutional neural networks performing both classification and segmentation of multiple abnormalities simultaneously. The proposed network is first trained by each abnormality separately. Then the network is trained using all abnormalities. In order to reduce the computational complexity, the network is redesigned to share some features which are common among all abnormalities. Later, these shared features are used in different settings (directions) to segment and classify the abnormal region of the image. Finally, results of the classification and segmentation directions are fused to obtain the classified segmentation map. Proposed framework is simulated using four frequent gastrointestinal abnormalities as well as three dermoscopic lesions and for evaluation of the proposed framework the results are compared with the corresponding ground truth map. Properties of the bifurcated network like low complexity and resource sharing make it suitable to be implemented as a part of portable medical imaging devices

Fully Convolutional Neural Networks to Detect Clinical Dermoscopic Features

The presence of certain clinical dermoscopic features within a skin lesion may indicate melanoma, and automatically detecting these features may lead to more quantitative and reproducible diagnoses. We reformulate the task of classifying clinical dermoscopic features within superpixels as a segmentation problem, and propose a fully convolutional neural network to detect clinical dermoscopic features from dermoscopy skin lesion images. Our neural network architecture uses interpolated feature maps from several intermediate network layers, and addresses imbalanced labels by minimizing a negative multi-label Dice-F$_1$ score, where the score is computed across the mini-batch for each label. Our approach ranked first place in the 2017 ISIC-ISBI Part 2: Dermoscopic Feature Classification Task challenge over both the provided validation and test datasets, achieving a 0.895% area under the receiver operator characteristic curve score. We show how simple baseline models can outrank state-of-the-art approaches when using the official metrics of the challenge, and propose to use a fuzzy Jaccard Index that ignores the empty set (i.e., masks devoid of positive pixels) when ranking models. Our results suggest that (i) the classification of clinical dermoscopic features can be effectively approached as a segmentation problem, and (ii) the current metrics used to rank models may not well capture the efficacy of the model. We plan to make our trained model and code publicly available.Comment: Accepted JBHI versio

Automatic Lesion Boundary Segmentation in Dermoscopic Images with Ensemble Deep Learning Methods

Early detection of skin cancer, particularly melanoma, is crucial to enable advanced treatment. Due to the rapid growth in the numbers of skin cancers, there is a growing need of computerized analysis for skin lesions. The state-of-the-art public available datasets for skin lesions are often accompanied with very limited amount of segmentation ground truth labeling as it is laborious and expensive. The lesion boundary segmentation is vital to locate the lesion accurately in dermoscopic images and lesion diagnosis of different skin lesion types. In this work, we propose the use of fully automated deep learning ensemble methods for accurate lesion boundary segmentation in dermoscopic images. We trained the Mask-RCNN and DeepLabv3+ methods on ISIC-2017 segmentation training set and evaluate the performance of the ensemble networks on ISIC-2017 testing set. Our results showed that the best proposed ensemble method segmented the skin lesions with Jaccard index of 79.58% for the ISIC-2017 testing set. The proposed ensemble method outperformed FrCN, FCN, U-Net, and SegNet in Jaccard Index by 2.48%, 7.42%, 17.95%, and 9.96% respectively. Furthermore, the proposed ensemble method achieved an accuracy of 95.6% for some representative clinically benign cases, 90.78% for the melanoma cases, and 91.29% for the seborrheic keratosis cases on ISIC-2017 testing set, exhibiting better performance than FrCN, FCN, U-Net, and SegNet.Comment: 7 pages, 8 figures and 4 tables. arXiv admin note: text overlap with arXiv:1711.1044

Skin Lesion Classification Using Deep Multi-scale Convolutional Neural Networks

We present a deep learning approach to the ISIC 2017 Skin Lesion Classification Challenge using a multi-scale convolutional neural network. Our approach utilizes an Inception-v3 network pre-trained on the ImageNet dataset, which is fine-tuned for skin lesion classification using two different scales of input images