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Artificial intelligence approaches to predicting and detecting cognitive decline in older adults: A conceptual review.
Preserving cognition and mental capacity is critical to aging with autonomy. Early detection of pathological cognitive decline facilitates the greatest impact of restorative or preventative treatments. Artificial Intelligence (AI) in healthcare is the use of computational algorithms that mimic human cognitive functions to analyze complex medical data. AI technologies like machine learning (ML) support the integration of biological, psychological, and social factors when approaching diagnosis, prognosis, and treatment of disease. This paper serves to acquaint clinicians and other stakeholders with the use, benefits, and limitations of AI for predicting, diagnosing, and classifying mild and major neurocognitive impairments, by providing a conceptual overview of this topic with emphasis on the features explored and AI techniques employed. We present studies that fell into six categories of features used for these purposes: (1) sociodemographics; (2) clinical and psychometric assessments; (3) neuroimaging and neurophysiology; (4) electronic health records and claims; (5) novel assessments (e.g., sensors for digital data); and (6) genomics/other omics. For each category we provide examples of AI approaches, including supervised and unsupervised ML, deep learning, and natural language processing. AI technology, still nascent in healthcare, has great potential to transform the way we diagnose and treat patients with neurocognitive disorders
Machine Learning for Multiclass Classification and Prediction of Alzheimer\u27s Disease
Alzheimer\u27s disease (AD) is an irreversible neurodegenerative disorder and a common form of dementia. This research aims to develop machine learning algorithms that diagnose and predict the progression of AD from multimodal heterogonous biomarkers with a focus placed on the early diagnosis. To meet this goal, several machine learning-based methods with their unique characteristics for feature extraction and automated classification, prediction, and visualization have been developed to discern subtle progression trends and predict the trajectory of disease progression.
The methodology envisioned aims to enhance both the multiclass classification accuracy and prediction outcomes by effectively modeling the interplay between the multimodal biomarkers, handle the missing data challenge, and adequately extract all the relevant features that will be fed into the machine learning framework, all in order to understand the subtle changes that happen in the different stages of the disease. This research will also investigate the notion of multitasking to discover how the two processes of multiclass classification and prediction relate to one another in terms of the features they share and whether they could learn from one another for optimizing multiclass classification and prediction accuracy.
This research work also delves into predicting cognitive scores of specific tests over time, using multimodal longitudinal data. The intent is to augment our prospects for analyzing the interplay between the different multimodal features used in the input space to the predicted cognitive scores. Moreover, the power of modality fusion, kernelization, and tensorization have also been investigated to efficiently extract important features hidden in the lower-dimensional feature space without being distracted by those deemed as irrelevant.
With the adage that a picture is worth a thousand words, this dissertation introduces a unique color-coded visualization system with a fully integrated machine learning model for the enhanced diagnosis and prognosis of Alzheimer\u27s disease. The incentive here is to show that through visualization, the challenges imposed by both the variability and interrelatedness of the multimodal features could be overcome. Ultimately, this form of visualization via machine learning informs on the challenges faced with multiclass classification and adds insight into the decision-making process for a diagnosis and prognosis
Alzheimers Disease Diagnosis using Machine Learning: A Review
Alzheimers Disease AD is an acute neuro disease that degenerates the brain
cells and thus leads to memory loss progressively. It is a fatal brain disease
that mostly affects the elderly. It steers the decline of cognitive and
biological functions of the brain and shrinks the brain successively, which in
turn is known as Atrophy. For an accurate diagnosis of Alzheimers disease,
cutting edge methods like machine learning are essential. Recently, machine
learning has gained a lot of attention and popularity in the medical industry.
As the illness progresses, those with Alzheimers have a far more difficult time
doing even the most basic tasks, and in the worst case, their brain completely
stops functioning. A persons likelihood of having early-stage Alzheimers
disease may be determined using the ML method. In this analysis, papers on
Alzheimers disease diagnosis based on deep learning techniques and
reinforcement learning between 2008 and 2023 found in google scholar were
studied. Sixty relevant papers obtained after the search was considered for
this study. These papers were analysed based on the biomarkers of AD and the
machine-learning techniques used. The analysis shows that deep learning methods
have an immense ability to extract features and classify AD with good accuracy.
The DRL methods have not been used much in the field of image processing. The
comparison results of deep learning and reinforcement learning illustrate that
the scope of Deep Reinforcement Learning DRL in dementia detection needs to be
explored.Comment: 10 pages and 3 figure
MildInt: Deep Learning-Based Multimodal Longitudinal Data Integration Framework
As large amounts of heterogeneous biomedical data become available, numerous methods for integrating such datasets have been developed to extract complementary knowledge from multiple domains of sources. Recently, a deep learning approach has shown promising results in a variety of research areas. However, applying the deep learning approach requires expertise for constructing a deep architecture that can take multimodal longitudinal data. Thus, in this paper, a deep learning-based python package for data integration is developed. The python package deep learning-based multimodal longitudinal data integration framework (MildInt) provides the preconstructed deep learning architecture for a classification task. MildInt contains two learning phases: learning feature representation from each modality of data and training a classifier for the final decision. Adopting deep architecture in the first phase leads to learning more task-relevant feature representation than a linear model. In the second phase, linear regression classifier is used for detecting and investigating biomarkers from multimodal data. Thus, by combining the linear model and the deep learning model, higher accuracy and better interpretability can be achieved. We validated the performance of our package using simulation data and real data. For the real data, as a pilot study, we used clinical and multimodal neuroimaging datasets in Alzheimer's disease to predict the disease progression. MildInt is capable of integrating multiple forms of numerical data including time series and non-time series data for extracting complementary features from the multimodal dataset
Early Identification of Alzheimer’s Disease Using Medical Imaging: A Review From a Machine Learning Approach Perspective
Alzheimer’s disease (AD) is the leading cause of dementia in aged adults, affecting up to 70% of the dementia patients, and posing a serious public health hazard in the twenty-first century. AD is a progressive, irreversible and neuro-degenerative disease with a long pre-clinical period, affecting brain cells leading to memory loss, misperception, learning problems, and improper decisions. Given its significance, presently no treatment options are available, although disease advancement can be retarded through medication. Unfortunately, AD is diagnosed at a very later stage, after irreversible damages to the brain cells have occurred, when there is no scope to prevent further cognitive decline. The use of non-invasive neuroimaging procedures capable of detecting AD at preliminary stages is crucial for providing treatment retarding disease progression, and has stood as a promising area of research. We conducted a comprehensive assessment of papers employing machine learning to predict AD using neuroimaging data. Most of the studies employed brain images from Alzheimer’s disease neuroimaging initiative (ADNI) dataset, consisting of magnetic resonance image (MRI) and positron emission tomography (PET) images. The most widely used method, the support vector machine (SVM), has a mean accuracy of 75.4 percent, whereas convolutional neural networks(CNN) have a mean accuracy of 78.5 percent. Better classification accuracy has been achieved by combining MRI and PET, rather using single neuroimaging technique. Overall, more complicated models, like deep learning, paired with multimodal and multidimensional data (neuroimaging, cognitive, clinical, behavioral and genetic) produced superlative results. However, promising results have been achieved, still there is a room for performance improvement of the proposed methods, providing assistance to healthcare professionals and clinician
Automated detection of Alzheimer disease using MRI images and deep neural networks- A review
Early detection of Alzheimer disease is crucial for deploying interventions
and slowing the disease progression. A lot of machine learning and deep
learning algorithms have been explored in the past decade with the aim of
building an automated detection for Alzheimer. Advancements in data
augmentation techniques and advanced deep learning architectures have opened up
new frontiers in this field, and research is moving at a rapid speed. Hence,
the purpose of this survey is to provide an overview of recent research on deep
learning models for Alzheimer disease diagnosis. In addition to categorizing
the numerous data sources, neural network architectures, and commonly used
assessment measures, we also classify implementation and reproducibility. Our
objective is to assist interested researchers in keeping up with the newest
developments and in reproducing earlier investigations as benchmarks. In
addition, we also indicate future research directions for this topic.Comment: 22 Pages, 5 Figures, 7 Table
Regression and Classification of Alzheimer’s Disease Diagnosis Using NMF-TDNet Features From 3D Brain MR Image
Because of headways in deep learning and clinical imaging innovation, a few specialists are presently utilizing convolutional neural networks (CNNs) to extricate profound level properties from clinical pictures to all the more exactly classify Alzheimer's disease (AD) and expect clinical scores. A limited scale profound learning network called PCANet utilizes principal component analysis (PCA) to make multi-facet channel banks for the incorporated learning of information. Blockwise histograms are made after binarization to get picture ascribes. PCANet is less versatile than different frameworks since the multi-facet channel banks are made involving test information and the produced highlights have aspects during the many thousands or even many thousands. To conquer these issues, we present in this study a PCANet-based, information free organization called the nonnegative matrix factorization tensor decomposition network (NMF-TDNet). To deliver the last picture highlights, we first form higher-request tensors and utilize tensor decomposition (TD) to achieve information dimensionality decrease. Specifically, we foster staggered channel banks for test getting the hang of utilizing nonnegative matrix factorization(NMF) as opposed to PCA. These properties serve as input to the support vector machine (SVM) that our technique employs to diagnose AD, forecast clinical score, and categorise AD
Hybrid Approach for Alzheimer’s Disease Diagnosis For 3D Brain MR Image
Because of headways in deep learning and clinical imaging innovation, a few specialists are presently utilizing convolutional neural networks (CNNs) to extricate profound level properties from clinical pictures to all the more exactly classify Alzheimer's disease (AD) and expect clinical scores. A limited scale profound learning network called PCANet utilizes principal component analysis (PCA) to make multi-facet channel banks for the incorporated learning of information. Blockwise histograms are made after binarization to get picture ascribes. PCANet is less versatile than different frameworks since the multi-facet channel banks are made involving test information and the produced highlights have aspects during the many thousands or even many thousands. To conquer these issues, we present in this study a PCANet-based, information free organization called the nonnegative matrix factorization tensor decomposition network (NMF-TDNet). To deliver the last picture highlights, we first form higher-request tensors and utilize tensor decomposition (TD) to achieve information dimensionality decrease. Specifically, we foster staggered channel banks for test getting the hang of utilizing nonnegative matrix factorization(NMF) as opposed to PCA. These properties serve as input to the support vector machine (SVM) that our technique employs to diagnose AD, forecast clinical score, and categorise AD
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