Ultrasound Signal Processing: From Models to Deep Learning

Medical ultrasound imaging relies heavily on high-quality signal processing algorithms to provide reliable and interpretable image reconstructions. Hand-crafted reconstruction methods, often based on approximations of the underlying measurement model, are useful in practice, but notoriously fall behind in terms of image quality. More sophisticated solutions, based on statistical modelling, careful parameter tuning, or through increased model complexity, can be sensitive to different environments. Recently, deep learning based methods have gained popularity, which are optimized in a data-driven fashion. These model-agnostic methods often rely on generic model structures, and require vast training data to converge to a robust solution. A relatively new paradigm combines the power of the two: leveraging data-driven deep learning, as well as exploiting domain knowledge. These model-based solutions yield high robustness, and require less trainable parameters and training data than conventional neural networks. In this work we provide an overview of these methods from the recent literature, and discuss a wide variety of ultrasound applications. We aim to inspire the reader to further research in this area, and to address the opportunities within the field of ultrasound signal processing. We conclude with a future perspective on these model-based deep learning techniques for medical ultrasound applications

Machine Learning for Beamforming in Audio, Ultrasound, and Radar

Multi-sensor signal processing plays a crucial role in the working of several everyday technologies, from correctly understanding speech on smart home devices to ensuring aircraft fly safely. A specific type of multi-sensor signal processing called beamforming forms a central part of this thesis. Beamforming works by combining the information from several spatially distributed sensors to directionally filter information, boosting the signal from a certain direction but suppressing others. The idea of beamforming is key to the domains of audio, ultrasound, and radar. Machine learning is the other central part of this thesis. Machine learning, and especially its sub-field of deep learning, has enabled breakneck progress in tackling several problems that were previously thought intractable. Today, machine learning powers many of the cutting edge systems we see on the internet for image classification, speech recognition, language translation, and more. In this dissertation, we look at beamforming pipelines in audio, ultrasound, and radar from a machine learning lens and endeavor to improve different parts of the pipelines using ideas from machine learning. We start off in the audio domain and derive a machine learning inspired beamformer to tackle the problem of ensuring the audio captured by a camera matches its visual content, a problem we term audiovisual zooming. Staying in the audio domain, we then demonstrate how deep learning can be used to improve the perceptual qualities of speech by denoising speech clipping, codec distortions, and gaps in speech. Transitioning to the ultrasound domain, we improve the performance of short-lag spatial coherence ultrasound imaging by exploiting the differences in tissue texture at each short lag value by applying robust principal component analysis. Next, we use deep learning as an alternative to beamforming in ultrasound and improve the information extraction pipeline by simultaneously generating both a segmentation map and B-mode image of high quality directly from raw received ultrasound data. Finally, we move to the radar domain and study how deep learning can be used to improve signal quality in ultra-wideband synthetic aperture radar by suppressing radio frequency interference, random spectral gaps, and contiguous block spectral gaps. By training and applying the networks on raw single-aperture data prior to beamforming, it can work with myriad sensor geometries and different beamforming equations, a crucial requirement in synthetic aperture radar