2,876 research outputs found
Regularized brain reading with shrinkage and smoothing
Functional neuroimaging measures how the brain responds to complex stimuli.
However, sample sizes are modest, noise is substantial, and stimuli are high
dimensional. Hence, direct estimates are inherently imprecise and call for
regularization. We compare a suite of approaches which regularize via
shrinkage: ridge regression, the elastic net (a generalization of ridge
regression and the lasso), and a hierarchical Bayesian model based on small
area estimation (SAE). We contrast regularization with spatial smoothing and
combinations of smoothing and shrinkage. All methods are tested on functional
magnetic resonance imaging (fMRI) data from multiple subjects participating in
two different experiments related to reading, for both predicting neural
response to stimuli and decoding stimuli from responses. Interestingly, when
the regularization parameters are chosen by cross-validation independently for
every voxel, low/high regularization is chosen in voxels where the
classification accuracy is high/low, indicating that the regularization
intensity is a good tool for identification of relevant voxels for the
cognitive task. Surprisingly, all the regularization methods work about equally
well, suggesting that beating basic smoothing and shrinkage will take not only
clever methods, but also careful modeling.Comment: Published at http://dx.doi.org/10.1214/15-AOAS837 in the Annals of
Applied Statistics (http://www.imstat.org/aoas/) by the Institute of
Mathematical Statistics (http://www.imstat.org
Discriminative Recurrent Sparse Auto-Encoders
We present the discriminative recurrent sparse auto-encoder model, comprising
a recurrent encoder of rectified linear units, unrolled for a fixed number of
iterations, and connected to two linear decoders that reconstruct the input and
predict its supervised classification. Training via
backpropagation-through-time initially minimizes an unsupervised sparse
reconstruction error; the loss function is then augmented with a discriminative
term on the supervised classification. The depth implicit in the
temporally-unrolled form allows the system to exhibit all the power of deep
networks, while substantially reducing the number of trainable parameters.
From an initially unstructured network the hidden units differentiate into
categorical-units, each of which represents an input prototype with a
well-defined class; and part-units representing deformations of these
prototypes. The learned organization of the recurrent encoder is hierarchical:
part-units are driven directly by the input, whereas the activity of
categorical-units builds up over time through interactions with the part-units.
Even using a small number of hidden units per layer, discriminative recurrent
sparse auto-encoders achieve excellent performance on MNIST.Comment: Added clarifications suggested by reviewers. 15 pages, 10 figure
SAFS: A Deep Feature Selection Approach for Precision Medicine
In this paper, we propose a new deep feature selection method based on deep
architecture. Our method uses stacked auto-encoders for feature representation
in higher-level abstraction. We developed and applied a novel feature learning
approach to a specific precision medicine problem, which focuses on assessing
and prioritizing risk factors for hypertension (HTN) in a vulnerable
demographic subgroup (African-American). Our approach is to use deep learning
to identify significant risk factors affecting left ventricular mass indexed to
body surface area (LVMI) as an indicator of heart damage risk. The results show
that our feature learning and representation approach leads to better results
in comparison with others
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