Question Classification in the Cancer Domain

We are investigating question classification for restricted domains with the broader goal of supporting mixed-initiative interaction on mobile phones. In this thesis, we present the development of a new domain-specific corpus of cancer-related questions, a new taxonomy of Expected Answer types, and our efforts toward training a classifier. This work is the first of its kind in the cancer domain using a corpus consisting of real user questions gathered from cQA websites, and a taxonomy built from that corpus. Our goal is to create software to engage newly diagnosed prostate cancer patients in question-answering dialogs related to their treatment options. We are focusing our work on the interaction environment afforded by text and multimedia (SMS and MMS) messaging using mobile telephones, because of the prevalence of this technology and the growing popularity of text messaging, especially among underserved populations

"Breast Cancer Prediction using Machine Learning Models"

Breast cancer is a type of cancer that develops in the cells of the breast. Treatment for breast cancer usually involves X-ray, chemotherapy, or a combination of both treatments. Detecting cancer at an early stage can save a person's life. Artificial intelligence (AI) plays a very important role in this area. Therefore, predicting breast cancer remains a very challenging issue for clinicians and researchers. This work aims to predict the probability of breast cancer in patients. Using machine learning (ML) models such as Multilayer Perceptron (MLP), K-Nearest Neightbot (KNN), AdaBoost (AB), Bagging, Gradient Boosting (GB), and Random Forest (RF). The breast cancer diagnostic medical dataset from the Wisconsin repository has been used. The dataset includes 569 observations and 32 features. Following the data analysis methodology, data cleaning, exploratory analysis, training, testing, and validation were performed. The performance of the models was evaluated with the parameters: classification accuracy, specificity, sensitivity, F1 count, and precision. The training and results indicate that the six trained models can provide optimal classification and prediction results. The RF, GB, and AB models achieved 100% accuracy, outperforming the other models. Therefore, the suggested models for breast cancer identification, classification, and prediction are RF, GB, and AB. Likewise, the Bagging, KNN, and MLP models achieved a performance of 99.56%, 95.82%, and 96.92%, respectively. Similarly, the last three models achieved an optimal yield close to 100%. Finally, the results show a clear advantage of the RF, GB, and AB models, as they achieve more accurate results in breast cancer prediction

Computational Logic for Biomedicine and Neurosciences

We advocate here the use of computational logic for systems biology, as a \emph{unified and safe} framework well suited for both modeling the dynamic behaviour of biological systems, expressing properties of them, and verifying these properties. The potential candidate logics should have a traditional proof theoretic pedigree (including either induction, or a sequent calculus presentation enjoying cut-elimination and focusing), and should come with certified proof tools. Beyond providing a reliable framework, this allows the correct encodings of our biological systems. % For systems biology in general and biomedicine in particular, we have so far, for the modeling part, three candidate logics: all based on linear logic. The studied properties and their proofs are formalized in a very expressive (non linear) inductive logic: the Calculus of Inductive Constructions (CIC). The examples we have considered so far are relatively simple ones; however, all coming with formal semi-automatic proofs in the Coq system, which implements CIC. In neuroscience, we are directly using CIC and Coq, to model neurons and some simple neuronal circuits and prove some of their dynamic properties. % In biomedicine, the study of multi omic pathway interactions, together with clinical and electronic health record data should help in drug discovery and disease diagnosis. Future work includes using more automatic provers. This should enable us to specify and study more realistic examples, and in the long term to provide a system for disease diagnosis and therapy prognosis

Intelligent data mining via evolutionary computing

Master'sMASTER OF ENGINEERIN

Predicting Rules for Cancer Subtype Classification using Grammar-Based Genetic Programming on various Genomic Data Types

With the advent of high-throughput methods more genomic data then ever has been generated during the past decade. As these technologies remain cost intensive and not worthwhile for every research group, databases, such as the TCGA and Firebrowse, emerged. While these database enable the fast and free access to massive amounts of genomic data, they also embody new challenges to the research community. This study investigates methods to obtain, normalize and process genomic data for computer aided decision making in the field of cancer subtype discovery. A new software, termed FirebrowseR is introduced, allowing the direct download of genomic data sets into the R programming environment. To pre-process the obtained data, a set of methods is introduced, enabling data type specific normalization. As a proof of principle, the Web-TCGA software is created, enabling fast data analysis. To explore cancer subtypes a statistical model, the EDL, is introduced. The newly developed method is designed to provide highly precise, yet interpretable models. The EDL is tested on well established data sets, while its performance is compared to state of the art machine learning algorithms. As a proof of principle, the EDL was run on a cohort of 1,000 breast cancer patients, where it reliably re-identified the known subtypes and automatically selected the corresponding maker genes, by which the subtypes are defined. In addition, novel patterns of alterations in well known maker genes could be identified to distinguish primary and mCRPC samples. The findings suggest that mCRPC is characterized through a unique amplification of the Androgen Receptor, while a significant fraction of primary samples is described by a loss of heterozygosity TP53 and NCOR1

Deployment of DeepTech AI Models in Engineering Solutions

Ponencia presentada en ICRAMAE-2k21, International Conference on Recent Advances in Mechanical and Automation Engineering, Vivekananda Global University, Jaipur, India, 29-30th November 2021[EN]Industrial Engineering is a branch of engineering that focuses on the design and operation of industrial processes. It involves the application of science to the construction of production systems. This field has undergone significant advancements over the last decades. In the last centuries, the emergence of different technologies has led to breakthroughs in engineering, making it possible to automate processes in industries. Steam, electricity, the internet, and now Artificial Intelligence technologies have all brought with them greater levels of automation to machinery, gradually decreasing human involvement in processes such as procurement, raw material handling, manufacturing and quality control

Pathway-Based Multi-Omics Data Integration for Breast Cancer Diagnosis and Prognosis.

Ph.D. Thesis. University of Hawaiʻi at Mānoa 2017

Reinforcement Learning

Brains rule the world, and brain-like computation is increasingly used in computers and electronic devices. Brain-like computation is about processing and interpreting data or directly putting forward and performing actions. Learning is a very important aspect. This book is on reinforcement learning which involves performing actions to achieve a goal. The first 11 chapters of this book describe and extend the scope of reinforcement learning. The remaining 11 chapters show that there is already wide usage in numerous fields. Reinforcement learning can tackle control tasks that are too complex for traditional, hand-designed, non-learning controllers. As learning computers can deal with technical complexities, the tasks of human operators remain to specify goals on increasingly higher levels. This book shows that reinforcement learning is a very dynamic area in terms of theory and applications and it shall stimulate and encourage new research in this field