12,750 research outputs found
Towards Automatic Generation of Shareable Synthetic Clinical Notes Using Neural Language Models
Large-scale clinical data is invaluable to driving many computational
scientific advances today. However, understandable concerns regarding patient
privacy hinder the open dissemination of such data and give rise to suboptimal
siloed research. De-identification methods attempt to address these concerns
but were shown to be susceptible to adversarial attacks. In this work, we focus
on the vast amounts of unstructured natural language data stored in clinical
notes and propose to automatically generate synthetic clinical notes that are
more amenable to sharing using generative models trained on real de-identified
records. To evaluate the merit of such notes, we measure both their privacy
preservation properties as well as utility in training clinical NLP models.
Experiments using neural language models yield notes whose utility is close to
that of the real ones in some clinical NLP tasks, yet leave ample room for
future improvements.Comment: Clinical NLP Workshop 201
Clinical Data Reuse or Secondary Use: Current Status and Potential Future Progress
Objective: To perform a review of recent research in clinical data reuse or secondary use, and envision future advances in this field. Methods: The review is based on a large literature search in MEDLINE (through PubMed), conference proceedings, and the ACM Digital Library, focusing only on research published between 2005 and early 2016. Each selected publication was reviewed by the authors, and a structured analysis and summarization of its content was developed. Results: The initial search produced 359 publications, reduced after a manual examination of abstracts and full publications. The following aspects of clinical data reuse are discussed: motivations and challenges, privacy and ethical concerns, data integration and interoperability, data models and terminologies, unstructured data reuse, structured data mining, clinical practice and research integration, and examples of clinical data reuse (quality measurement and learning healthcare systems). Conclusion: Reuse of clinical data is a fast-growing field recognized as essential to realize the potentials for high quality healthcare, improved healthcare management, reduced healthcare costs, population health management, and effective clinical research
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