Town of Cumberland Town Council Meeting April 27, 1998

Town of Cumberland Town Council Meeting April 27, 1998 is the complete packet for the Cumberland Town Council meeting for April 27, 1998, and includes the minutes of the Town Council meeting of April 6, 1998. Agenda items include: 98 - 027. To hold a Public Hearing to consider and act to authorize the Town Manager to approve aerial spraying in affected areas. 98 - 028. To set dates for bulky-waste pickup: Mainland: May 4 - May 8 and October 19 - 23, 1998 and Chebeague Island: August 7 - 9, 1998. 98 - 029. To set date for workshop with Cumberland Cemetery Association. 98 - 030. To consider and act on application of Innco. Inc. for a Liquor License for the Chebeague Island Inn. 98 - 031. To consider and act on application of Sarah Wicker, d/b/a Viking Grill for a Victualer’s license. 98 - 032. To appoint Election Clerks. 98 - 033. To set fees for Victualer’s licenses. 98 - 034. To set date for workshop with the Lands Committee. 98 - 035. To set date for special meeting to swear in newly elected Town Councilors. 98 - 036. To set date for second Town Council Meeting in May

Town of Cumberland Town Council Meeting May 11, 1998

Town of Cumberland Town Council Meeting May 11, 1998 is the complete packet for the Cumberland Town Council meeting for May 11, 1998, and includes the minutes of the Town Council meeting of April 27, 1998. Agenda items include: 98 - 037. To receive report of Cumberland Tax Acquired Property Committee. 98 - 038. To consider and act on request for property tax abatements. 98 - 039. To set date for Public Hearing on proposed Town Ways Ordinance. 98 - 040. To ratify amendments to Cumberland Housing Authority Bylaws: (1) Change fiscal year to calendar year. (2) Increase the Cumberland Housing Authority to seven members. 98 - 041. To set date for Public Hearing - Comprehensive Plan. 98 - 042. To re-set date for second Town Council Meeting in May. 98 - 043. To set date for Public Hearing to consider and act on application for a Mass Gathering Permit by the United Maine Craftsmen to hold the annual craft fair at the Cumberland Fairgrounds August 6th through August 9, 1998

Town of Cumberland Town Council Meeting March 9, 1998

Town of Cumberland Town Council Meeting March 9, 1998 is the complete packet for the Cumberland Town Council meeting for March 9, 1998. Agenda items include: 98 - 012. To review report of Maine Forest Service and consider declaration of public health hazard in regard to Brown Trail Moth infestation and set date for public hearing on possible aerial spraying program. 98 - 013. To ratify contract with Cumberland Police Benevolent Association. 98 - 014. To hear report of Recycling Committee. 98 - 015. To endorse the submittal of a Community Development Block Grant by the Town on behalf of Chebeague Care Resource. 98 - 016. To appoint Plumbing Inspector and alternates. 98 - 017. To set date for Public Hearing to consider an amendment to the Zoning Ordinance to allow “Construction Operations” as a permitted use in the Rural Industrial District. 98 - 018. To set date for a Public Hearing to consider and grant a liquor license to the Cumberland Cafe

Town of Cumberland Town Council Meeting December 21, 1998

Town of Cumberland Town Council Meeting December 21, 1998 is the complete packet for the Cumberland Town Council meeting for December 21, 1998, and includes the minutes of the Town Council meeting of November 23, 1998. Agenda items include: 98 - 135. To set date for Public Hearing to discuss the issues of open space and to consider recommending a moratorium on new residential subdivisions. 98 - 136. To set date for Public Hearing to consider and act on amendments to Sec. 204.6 and Sec. 204.7 of the Zoning Ordinance. The amendments propose adding the use of boarding kennels to the Local Business (LB) district, and the Highway Commercial (HC) district along Route 100. 98 - 137. To set date for Public Hearing to consider amendments to the Zoning Ordinance that defines boarding kennels, and private kennels. 98 - 138. To set date for Public Hearing to review and consider recommending amendments to the official zoning map. 98 - 139. To set date for Public Hearing to consider an amendment to the Zoning Ordinance regarding day care centers and nursery schools, amendment proposals include, limiting new day care centers and nursery schools in the RR 1, RR 2, MDR, and LDR districts to 16 children and allowing existing centers to expand to 30 children. 98 - 140. To set date for Public Hearing to consider and act on an amendment to the Zoning Ordinance regarding the requirement that 25% of the multiplex units in the northern Office Commercial (OC) district be affordable. (Sec. 204.8.1.5.1) This is a technical amendment that updates the reference to a state law that has been repealed. 98 - 141. To set date for bulky waste pickup, Mainland and Island. 98 - 142. Nominating Committee appointments

Town of Cumberland Town Council Meeting March 9, 1998

Town of Cumberland Town Council Meeting March 9, 1998 is the complete packet for the Cumberland Town Council meeting for March 9, 1998. Agenda items include: 98 - 012. To review report of Maine Forest Service and consider declaration of public health hazard in regard to Brown Trail Moth infestation and set date for public hearing on possible aerial spraying program. 98 - 013. To ratify contract with Cumberland Police Benevolent Association. 98 - 014. To hear report of Recycling Committee. 98 - 015. To endorse the submittal of a Community Development Block Grant by the Town on behalf of Chebeague Care Resource. 98 - 016. To appoint Plumbing Inspector and alternates. 98 - 017. To set date for Public Hearing to consider an amendment to the Zoning Ordinance to allow “Construction Operations” as a permitted use in the Rural Industrial District. 98 - 018. To set date for a Public Hearing to consider and grant a liquor license to the Cumberland Cafe

The newly developed CRF1-receptor antagonists, NGD 98-2 and NGD 9002, suppress acute stress-induced stimulation of colonic motor function and visceral hypersensitivity in rats.

Corticotropin releasing factor receptor 1 (CRF1) is the key receptor that mediates stress-related body responses. However to date there are no CRF1 antagonists that have shown clinical efficacy in stress-related diseases. We investigated the inhibitory effects of a new generation, topology 2 selective CRF1 antagonists, NGD 98-2 and NGD 9002 on exogenous and endogenous CRF-induced stimulation of colonic function and visceral hypersensitivity to colorectal distension (CRD) in conscious rats. CRF1 antagonists or vehicle were administered orogastrically (og) or subcutaneously (sc) before either intracerebroventricular (icv) or intraperitoneal (ip) injection of CRF (10 µg/kg), exposure to water avoidance stress (WAS, 60 min) or repeated CRD (60 mmHg twice, 10 min on/off at a 30 min interval). Fecal pellet output (FPO), diarrhea and visceromotor responses were monitored. In vehicle (og)-pretreated rats, icv CRF stimulated FPO and induced diarrhea in >50% of rats. NGD 98-2 or NGD 9002 (3, 10 and 30 mg/kg, og) reduced the CRF-induced FPO response with an inhibitory IC50 of 15.7 and 4.3 mg/kg respectively. At the highest dose, og NGD 98-2 or NGD 9002 blocked icv CRF-induced FPO by 67-87% and decreased WAS-induced-FPO by 23-53%. When administered sc, NGD 98-2 or NGD 9002 (30 mg/kg) inhibited icv and ip CRF-induced-FPO. The antagonists also prevented the development of nociceptive hyper-responsivity to repeated CRD. These data demonstrate that topology 2 CRF1 antagonists, NGD 98-2 and NGD 9002, administered orally, prevented icv CRF-induced colonic secretomotor stimulation, reduced acute WAS-induced defecation and blocked the induction of visceral sensitization to repeated CRD

Revisiting Epidermal Growth Factor Receptor (EGFR) Amplification as a Target for Anti-EGFR Therapy: Analysis of Cell-Free Circulating Tumor DNA in Patients With Advanced Malignancies.

PurposeTo date, evidence for tissue epidermal growth factor receptor (EGFR) overexpression as a biomarker for anti-EGFR therapies has been weak. We investigated the genomic landscape of EGFR amplification in blood-derived cell-free tumor DNA (cfDNA) across diverse cancers and the role of anti-EGFR therapies in achieving response.MethodsWe assessed EGFR amplification status among 28,584 patients with malignancies evaluated by clinical-grade next-generation sequencing (NGS) of blood-derived cfDNA (54- to 73-gene panel). Furthermore, we curated the clinical characteristics of 1,434 patients at the University of California San Diego who had cfDNA testing by this NGS test.ResultsOverall, EGFR amplification was detected in cfDNA from 8.5% of patients (2,423 of 28,584), most commonly in colorectal (16.3% [458 of 2,807]), non-small-cell lung (9.0% [1,096 of 12,197]), and genitourinary cancers (8.1% [170 of 2,104]). Most patients had genomic coalterations (96.9% [95 of 98]), frequently involving genes affecting other tyrosine kinases (72.4% [71 of 98]), mitogen-activated protein kinase cascades (56.1% [55 of 98]), cell-cycle-associated signals (52.0% [51 of 98]), and the phosphoinositide 3-kinase pathway (35.7% [35 of 98]). EGFR amplification emerged in serial cfDNA after various anticancer therapies (n = 6), including checkpoint inhibitors (n = 4), suggesting a possible role for these amplifications in acquired resistance. Nine evaluable patients with EGFR amplification were treated with anti-EGFR-based regimens; five (55.6%) achieved partial responses, including three patients whose tissue NGS lacked EGFR amplification.ConclusionEGFR amplification was detected in cfDNA among 8.5% of 28,584 diverse cancers. Most patients had coexisting alterations. Responses were observed in five of nine patients who received EGFR inhibitors. Incorporating EGFR inhibitors into the treatment regimens of patients harboring EGFR amplification in cfDNA merits additional study

Kārawān, 1350-10-30, 1972-01-20

The volume and issue of this edition is Kārawān, v. 4, no. 98. The numbers in the title refer to the date of the edition, with the first set of numbers representing the Persian calendar and the second set of numbers representing the date in the Gregorian calendar. Editor: 1972- Abdul Haq Waleh. Title transliterated into English : Caravan. Salurum kal̄, Ata navyayuma ganạh [vol. 4, no. 98] (Jadi. 30, 1350 [January 20, 1972]).https://digitalcommons.unomaha.edu/karawan/1876/thumbnail.jp

Kārawān, 1349-11-01, 1971-01-21

The volume and issue of this edition is Kārawān, v. 3, no. 98. The numbers in the title refer to the date of the edition, with the first set of numbers representing the Persian calendar and the second set of numbers representing the date in the Gregorian calendar. Editor: 1971- Abdul Haq Waleh. Title transliterated into English : Caravan. Dreyum kal̄, Ata navyayuma ganạh [vol. 3, no. 98] (Dalwa. 1, 1349 [January 21, 1971]).https://digitalcommons.unomaha.edu/karawan/2018/thumbnail.jp

Kārawān, 1351-11-12, 1973-02-01

The volume and issue of this edition is Kārawān, v. 5, no. 98. The numbers in the title refer to the date of the edition, with the first set of numbers representing the Persian calendar and the second set of numbers representing the date in the Gregorian calendar. Editor: 1973- Abdul Haq Waleh. Title transliterated into English : Caravan. Pinzahum kal̄, Ata navyayuma ganạh [vol. 5, no. 98] (Dalwa. 12, 1351 [February 1, 1973]).https://digitalcommons.unomaha.edu/karawan/1581/thumbnail.jp