Wormbase Curation Interfaces and Tools

Curating biological information from the published literature can be time- and labor-intensive especially without automated tools. WormBase1 has adopted several curation interfaces and tools, most of which were built in-house, to help curators recognize and extract data more efficiently from the literature. These tools range from simple computer interfaces for data entry to employing scripts that take advantage of complex text extraction algorithms, which automatically identify specific objects in a paper and presents them to the curator for curation. By using these in-house tools, we are also able to tailor the tool to the individual needs and preferences of the curator. For example, Gene Ontology Cellular Component and gene-gene interaction curators employ the text mining software Textpresso2 to indentify, retrieve, and extract relevant sentences from the full text of an article. The curators then use a web-based curation form to enter the data into our local database. For transgene and antibody curation, curators use the publicly available Phenote ontology annotation curation interface (developed by the Berkeley Bioinformatics Open-Source Projects (BBOP)), which we have adapted with datatype specific configurations. This tool has been used as a basis for developing our own Ontology Annotator tool, which is being used by our phenotype and gene ontology curators. For RNAi curation, we created web-based submission forms that allow the curator to efficiently capture all relevant information. In all cases, the data undergoes a final scripted data dump step to make sure all the information conforms into a readable file by our object oriented database

Using Sound to Enhance Users’ Experiences of Mobile Applications

The latest smartphones with GPS, electronic compass, directional audio, touch screens etc. hold potentials for location based services that are easier to use compared to traditional tools. Rather than interpreting maps, users may focus on their activities and the environment around them. Interfaces may be designed that let users search for information by simply pointing in a direction. Database queries can be created from GPS location and compass direction data. Users can get guidance to locations through pointing gestures, spatial sound and simple graphics. This article describes two studies testing prototypic applications with multimodal user interfaces built on spatial audio, graphics and text. Tests show that users appreciated the applications for their ease of use, for being fun and effective to use and for allowing users to interact directly with the environment rather than with abstractions of the same. The multimodal user interfaces contributed significantly to the overall user experience

Tomato Functional Genomics Database: a comprehensive resource and analysis package for tomato functional genomics

Tomato Functional Genomics Database (TFGD) provides a comprehensive resource to store, query, mine, analyze, visualize and integrate large-scale tomato functional genomics data sets. The database is functionally expanded from the previously described Tomato Expression Database by including metabolite profiles as well as large-scale tomato small RNA (sRNA) data sets. Computational pipelines have been developed to process microarray, metabolite and sRNA data sets archived in the database, respectively, and TFGD provides downloads of all the analyzed results. TFGD is also designed to enable users to easily retrieve biologically important information through a set of efficient query interfaces and analysis tools, including improved array probe annotations as well as tools to identify co-expressed genes, significantly affected biological processes and biochemical pathways from gene expression data sets and miRNA targets, and to integrate transcript and metabolite profiles, and sRNA and mRNA sequences. The suite of tools and interfaces in TFGD allow intelligent data mining of recently released and continually expanding large-scale tomato functional genomics data sets. TFGD is available at http://ted.bti.cornell.edu

sORFs.org : a repository of small ORFs identified by ribosome profiling

With the advent of ribosome profiling, a next generation sequencing technique providing a ‘snap-shot’ of translated mRNA in a cell, many short open reading frames (sORFs) with were identified. Follow-up studies revealed the existence of functional peptides, so-called micropeptides, translated from these ‘sORFs’, indicating a new class of bio-active peptides. Over the last few years, several micropeptides exhibiting important cellular functions were discovered. However, ribosome occupancy does not necessarily imply an actual function of the translated peptide, leading to the development of various tools assessing the coding potential of sORFs. Here, we introduce sORFs.org (http://www.sorfs.org), a novel database for sORFs identified using ribosome profiling. Starting from ribosome profiling, sORFs.org identifies sORFs, incorporates state-of-the-art tools and metrics and stores results in a public database. Two query interfaces are provided, a default one enabling quick lookup of sORFs and a BioMart interface providing advanced query and export possibilities. At present, sORFs.org harbors 263 354 sORFs that demonstrate ribosome occupancy, originating from three different cell lines: HCT116 (human), E14_mESC (mouse) and S2 (fruit fly). sORFs.org aims to provide an extensive sORFs database accessible to researchers with limited bioinformatics knowledge, thus enabling easy integration into personal projects

CCDB 13 years on

The Computer Centre DataBase (CCDB) has been in operation for over thirteen years. This paper discusses how the project was initiated, the structure of the database and its interfaces and services, and how it has evolved from the time of mainframe computing to today's situation of highly inter-related distributed computer services. The primary CCDB services provided include management of computer services, accounts, e-mail addresses and e-mail routing, resources (such as CPU, disk space) and provision of data for the division's information dissemination tools such as xwho, phone and phonebook. It feeds data to these tools and many other database applications CERN-wide and uses/provides data from/to HR (Human Resources) and Landb (IT networking database)

Some issues in data model mapping

Numerous data models have been reported in the literature since the early 1970's. They have been used as database interfaces and as conceptual design tools. The mapping between schemas expressed according to the same data model or according to different models is interesting for theoretical and practical purposes. This paper addresses some of the issues involved in such a mapping. Of special interest are the identification of the mapping parameters and some current approaches for handling the various situations that require a mapping

The GalMer database: Galaxy Mergers in the Virtual Observatory

We present the GalMer database, a library of galaxy merger simulations, made available to users through tools compatible with the Virtual Observatory (VO) standards adapted specially for this theoretical database. To investigate the physics of galaxy formation through hierarchical merging, it is necessary to simulate galaxy interactions varying a large number of parameters: morphological types, mass ratios, orbital configurations, etc. On one side, these simulations have to be run in a cosmological context, able to provide a large number of galaxy pairs, with boundary conditions given by the large-scale simulations, on the other side the resolution has to be high enough at galaxy scales, to provide realistic physics. The GalMer database is a library of thousands simulations of galaxy mergers at moderate spatial resolution and it is a compromise between the diversity of initial conditions and the details of underlying physics. We provide all coordinates and data of simulated particles in FITS binary tables. The main advantages of the database are VO access interfaces and value-added services which allow users to compare the results of the simulations directly to observations: stellar population modelling, dust extinction, spectra, images, visualisation using dedicated VO tools. The GalMer value-added services can be used as virtual telescope producing broadband images, 1D spectra, 3D spectral datacubes, thus making our database oriented towards the usage by observers. We present several examples of the GalMer database scientific usage obtained from the analysis of simulations and modelling their stellar population properties, including: (1) studies of the star formation efficiency in interactions; (2) creation of old counter-rotating components; (3) reshaping metallicity profiles in elliptical galaxies; (4) orbital to internal angular momentum transfer; (5) reproducing observed colour bimodality of galaxies.Comment: 15 pages, 11 figures, 10 tables accepted to A&A. Visualisation of GalMer simulations, access to snapshot files and value-added tools described in the paper are available at http://galmer.obspm.fr