NELFE-Dependent MYC Signature Identifies a Unique Cancer Subtype in Hepatocellular Carcinoma.

The MYC oncogene is dysregulated in approximately 30% of liver cancer. In an effort to exploit MYC as a therapeutic target, including in hepatocellular carcinoma (HCC), strategies have been developed on the basis of MYC amplification or gene translocation. Due to the failure of these strategies to provide accurate diagnostics and prognostic value, we have developed a Negative Elongation Factor E (NELFE)-Dependent MYC Target (NDMT) gene signature. This signature, which consists of genes regulated by MYC and NELFE, an RNA binding protein that enhances MYC-induced hepatocarcinogenesis, is predictive of NELFE/MYC-driven tumors that would otherwise not be identified by gene amplification or translocation alone. We demonstrate the utility of the NDMT gene signature to predict a unique subtype of HCC, which is associated with a poor prognosis in three independent cohorts encompassing diverse etiologies, demographics, and viral status. The application of gene signatures, such as the NDMT signature, offers patients access to personalized risk assessments, which may be utilized to direct future care

The role of alcohol in crime and disorder

Looking into the Australian culture of drinking and the correlations it has with crime numbers. Four out of five Australians aged over 14 years report being recent drinkers and one in five report drinking seven or more drinks on a single occasion at least monthly. 1 Two-thirds (61 per cent) of 18–29-year-olds report consuming alcohol for the purpose of getting drunk.2 The annual cost of alcohol-related harm in Australia is estimated between $15.63 and$36 billion,4 depending on the model used and whether harm to others is included in the model. The personal cost of alcohol-related trauma to many individuals is overwhelming.4 Virtually every type of alcohol-related harm is on the rise in Australia.5 This report provides a review of the literature and statistics related to alcohol consumption and crime and disorder in Australia and Victoria. This paper is part of a ‘suite’ of resources for government (local, state and federal), the justice sector, health professionals and associated agencies. It offers an overview of proven and promising strategies for reducing alcohol-influenced crime and disorder

Developing Model-Based Design Evaluation for Pipelined A/D Converters

This paper deals with a prospective approach of modeling, design evaluation and error determination applied to pipelined A/D converter architecture. In contrast with conventional ADC modeling algorithms targeted to extract the maximum ADC non-linearity error, the innovative approach presented allows to decompose magnitudes of individual error sources from a measured or simulated response of an ADC device. Design Evaluation methodology was successfully applied to Nyquist rate cyclic converters in our works [13]. Now, we extend its principles to pipelined architecture. This qualitative decomposition can significantly contribute to the ADC calibration procedure performed on the production line in term of integral and differential nonlinearity. This is backgrounded by the fact that the knowledge of ADC performance contributors provided by the proposed method helps to adjust the values of on-chip converter components so as to equalize (and possibly minimize) the total non-linearity error. In this paper, the design evaluation procedure is demonstrated on a system design example of pipelined A/D converter. Significant simulation results of each stage of the design evaluation process are given, starting from the INL performance extraction proceeded in a powerful Virtual Testing Environment implemented in Maple™ software and finishing by an error source simulation, modeling of pipelined ADC structure and determination of error source contribution, suitable for a generic process flow

The Effect of Student Team Achievement Divisions (Stad) and Learning Motivation Toward the Students' Reading Competence of the Eighth Year Students of SMP N 3 Ubud in the Academic Year 2012/2013

This study was an experimental research which aimed at identifying the effect of implementation of Student Team Achievement Division (STAD) and learning motivation toward students' reading competence. This research used 2x2 factorial designs. The data collected through test and analyzed by using statistical Two-Way Anova and Tukey Test. The population was 4 classes (197 students) of grade VIII SMP Negeri 3 UBUD in academic year 2012/2013 in which 2 classes were chosen as the sample of the study. The chosen of two classes as a sample used intact Random Sampling. The results of the research were first, there was a significant different effect between the students taught by using STAD method and conventional method. Second, there was an effect of learning motivation toward student reading competence. Third, there was a significant interactional effect between implementation of student's team achievement division (STAD) and Learning motivation toward students reading competence. Forth, there was a significant different effect between the students having high motivation taught by using student team achievement division (STAD) and conventional method. Fifth, there was a significant different effect between the student having low motivation taught by using student team achievement division (STAD) and conventional method

A Scalable Low-Cost-UAV Traffic Network (uNet)

This article proposes a new Unmanned Aerial Vehicle (UAV) operation paradigm to enable a large number of relatively low-cost UAVs to fly beyond-line-of-sight without costly sensing and communication systems or substantial human intervention in individual UAV control. Under current free-flight-like paradigm, wherein a UAV can travel along any route as long as it avoids restricted airspace and altitudes. However, this requires expensive on-board sensing and communication as well as substantial human effort in order to ensure avoidance of obstacles and collisions. The increased cost serves as an impediment to the emergence and development of broader UAV applications. The main contribution of this work is to propose the use of pre-established route network for UAV traffic management, which allows: (i) pre- mapping of obstacles along the route network to reduce the onboard sensing requirements and the associated costs for avoiding such obstacles; and (ii) use of well-developed routing algorithms to select UAV schedules that avoid conflicts. Available GPS-based navigation can be used to fly the UAV along the selected route and time schedule with relatively low added cost, which therefore, reduces the barrier to entry into new UAV-applications market. Finally, this article proposes a new decoupling scheme for conflict-free transitions between edges of the route network at each node of the route network to reduce potential conflicts between UAVs and ensuing delays. A simulation example is used to illustrate the proposed uNet approach.Comment: To be submitted to journal, 21 pages, 9 figure

A fundamental approach to the sticking of insect residues to aircraft wings

A proposed testing scheme is described for obtaining data on the effects of surface roughness and surface energy on insect adhesion. The road test apparatus is discussed as well as surface preparation techniques. Uncoated and polymer coated metal substrates were analyzed by SEM/ESCA/IRS before and following collision with insects. Critical surface tensions of unexposed Nyebar and poly sulfone coatings were 10 and 33 dynes/cm, respectively, as determined from contact angles. A total of 95% of insect residues collected belong to order Diptera. Significantly less insect debris was detected on the coated plates as compared to the uncoated plates. Minimal contamination at the 5 nm level of both coated and uncoated plates occurs even after hours of exposure to road conditions as determined by ESCA analysis. The presence of nitrogen detected by ESCA on exposed plates is unequivocal evidence for insect residues left on plates

Peningkatan Kemampuan Berpikir Kritis Melalui Pendekatan Problem Solving Berbasis Pembelajaran Kooperatif Tipe Student Teams Achievement Division (STAD) (PTK Pada Siswa Kelas VIII SMP N 4 Satu Atap Kismantoro Wonogiri Tahun Ajaran 2012/2013)

Penelitian ini bertujuan untuk mendeskripsikan peningkatan kemampuan berpikir kritis siswa melalui penerapan pendekatan problem solving berbasis pembelajaran kooperatif tipe STAD. Jenis penelitian ini adalah penelitian tindakan kelas. Subyek penelitian adalah guru yang memberikan tindakan kelas dan penerima tindakan adalah siswa kelas VIII SMP N 4 Satu Atap Kismantoro Wonogiri yang berjumlah 46 siswa. Metode pengumpulan data dilakukan melalui observasi, catatan lapangan, dokumentasi, dan tes. Teknik analisis data dilakukan secara deskriptif kualitatif dengan metode alur yang dianalisis dari tindakan pembelajaran dilaksanakan dan dikembangkan selama proses pembelajaran. Validitas data menggunakan teknik triangulasi, yaitu triangulasi metode. Hasil penelitian menunjukkan adanya peningkatan kemampuan berpikir kritis siswa. Penemuan dari penelitian menunjukkan: 1)siswa berusaha mengetahui informasi dengan baik 86,96%; 2) kemampuan siswa dalam merumuskan pokok-pokok permasalahan 80,44%; 3) kemampuan siswa dalam mencari alternatif 65,22%; 4) kemampuan siswa dalam mengurutkan langkah-langkah penyelesaian masalah 84,78%; 5) kemampuan siswa dalam mengungkapkan data dalam menyelesaikan masalah 73,91%; 6) kemampuan siswa dalam mengevaluasi argumen dalam menyelesaikan masalah 63,04%. Sehingga disimpulkan bahwa penggunaan pendekatan problem solving berbasis STAD dalam pembelajaran matematika dapat meningkatkan kemampuan berpikir kritis siswa

Application of the STAD-Type Cooperative Model Assisted by Wordwall to Enhance Students Critical Thinking Ability

An advanced nation begins with individuals who are able to compete with other individuals based on the standards of ability needed by the world community, which are known as 21st-century abilities, one of which is the critical thinking ability. The application of the STAD-type cooperative model assisted by Wordwall aims to describe students critical thinking abilities and find differences in critical thinking abilities between control and experiment classes. The research design used nonequivalent post-test only control group. This research included all students in class X of MIPA SMA Muhammadiyah 1 Pekanbaru as a population. A sample of 66 students consisted of X MIPA 1 as control class and X MIPA 5 as experiment class. After the research was carried out, a critical thinking abilities post-test was given, which consisted of 12 multiple-choice questions as an instrument for data collection. Post-test results were analyzed using descriptive analysis and inferential. The results of the descriptive analysis showed that the experiment class was in the very good category with score 80.99, and the control class was in the good category with score 61.03. Then, in the inferential analysis, it is known that there are significant differences between experiment and control clas