Bridging data management platforms and visualization tools to enable ad-hoc and smart analytics in life sciences

Core facilities have to offer technologies that best serve the needs of their users and provide them a competitive advantage in research. They have to set up and maintain instruments in the range of ten to a hundred, which produce large amounts of data and serve thousands of active projects and customers. Particular emphasis has to be given to the reproducibility of the results. More and more, the entire process from building the research hypothesis, conducting the experiments, doing the measurements, through the data explorations and analysis is solely driven by very few experts in various scientific fields. Still, the ability to perform the entire data exploration in real-time on a personal computer is often hampered by the heterogeneity of software, the data structure formats of the output, and the enormous data sizes. These impact the design and architecture of the implemented software stack. At the Functional Genomics Center Zurich (FGCZ), a joint state-of-the-art research and training facility of ETH Zurich and the University of Zurich, we have developed the B-Fabric system, which has served for more than a decade, an entire life sciences community with fundamental data science support. In this paper, we sketch how such a system can be used to glue together data (including metadata), computing infrastructures (clusters and clouds), and visualization software to support instant data exploration and visual analysis. We illustrate our in-daily life implemented approach using visualization applications of mass spectrometry data

Barry Smith an sich

Festschrift in Honor of Barry Smith on the occasion of his 65th Birthday. Published as issue 4:4 of the journal Cosmos + Taxis: Studies in Emergent Order and Organization. Includes contributions by Wolfgang Grassl, Nicola Guarino, John T. Kearns, Rudolf Lüthe, Luc Schneider, Peter Simons, Wojciech Żełaniec, and Jan Woleński

Incorporating Domain-Specific Information Quality Constraints into Database Queries

The range of information now available in queryable repositories opens up a host of possibilities for new and valuable forms of data analysis. Database query languages such as SQL and XQuery offer a concise and high-level means by which such analyses can be implemented, facilitating the extraction of relevant data subsets into either generic or bespoke data analysis environments. Unfortunately, the quality of data in these repositories is often highly variable. The data is still useful, but only if the consumer is aware of the data quality problems and can work around them. Standard query languages offer little support for this aspect of data management. In principle, however, it should be possible to embed constraints describing the consumer’s data quality requirements into the query directly, so that the query evaluator can take over responsibility for enforcing them during query processing. Most previous attempts to incorporate information quality constraints into database queries have been based around a small number of highly generic quality measures, which are defined and computed by the information provider. This is a useful approach in some application areas but, in practice, quality criteria are more commonly determined by the user of the information not by the provider. In this paper, we explore an approach to incorporating quality constraints into databas

Menetelmiä mielenkiintoisten solmujen löytämiseen verkostoista

With the increasing amount of graph-structured data available, finding interesting objects, i.e., nodes in graphs, becomes more and more important. In this thesis we focus on finding interesting nodes and sets of nodes in graphs or networks. We propose several definitions of node interestingness as well as different methods to find such nodes. Specifically, we propose to consider nodes as interesting based on their relevance and non-redundancy or representativeness w.r.t. the graph topology, as well as based on their characterisation for a class, such as a given node attribute value. Identifying nodes that are relevant, but non-redundant to each other is motivated by the need to get an overview of different pieces of information related to a set of given nodes. Finding representative nodes is of interest, e.g. when the user needs or wants to select a few nodes that abstract the large set of nodes. Discovering nodes characteristic for a class helps to understand the causes behind that class. Next, four methods are proposed to find a representative set of interesting nodes. The first one incrementally picks one interesting node after another. The second iteratively changes the set of nodes to improve its overall interestingness. The third method clusters nodes and picks a medoid node as a representative for each cluster. Finally, the fourth method contrasts diverse sets of nodes in order to select nodes characteristic for their class, even if the classes are not identical across the selected nodes. The first three methods are relatively simple and are based on the graph topology and a similarity or distance function for nodes. For the second and third, the user needs to specify one parameter, either an initial set of k nodes or k, the size of the set. The fourth method assumes attributes and class attributes for each node, a class-related interesting measure, and possible sets of nodes which the user wants to contrast, such as sets of nodes that represent different time points. All four methods are flexible and generic. They can, in principle, be applied on any weighted graph or network regardless of what nodes, edges, weights, or attributes represent. Application areas for the methods developed in this thesis include word co-occurrence networks, biological networks, social networks, data traffic networks, and the World Wide Web. As an illustrating example, consider a word co-occurrence network. There, finding terms (nodes in the graph) that are relevant to some given nodes, e.g. branch and root, may help to identify different, shared contexts such as botanics, mathematics, and linguistics. A real life application lies in biology where finding nodes (biological entities, e.g. biological processes or pathways) that are relevant to other, given nodes (e.g. some genes or proteins) may help in identifying biological mechanisms that are possibly shared by both the genes and proteins.Väitöskirja käsittelee verkostojen louhinnan menetelmiä. Sen tavoitteena on löytää mielenkiintoisia tietoja painotetuista verkoista. Painotettuna verkkona voi tarkastella esim. tekstiainestoja, biologisia ainestoja, ihmisten välisiä yhteyksiä tai internettiä. Tällaisissa verkoissa solmut edustavat käsitteitä (esim. sanoja, geenejä, ihmisiä tai internetsivuja) ja kaaret niiden välisiä suhteita (esim. kaksi sanaa esiintyy samassa lauseessa, geeni koodaa proteiinia, ihmisten ystävyyksiä tai internetsivu viittaa toiseen internetsivuun). Kaarten painot voivat vastata esimerkiksi yhteyden voimakuutta tai luotettavuutta. Väitöskirjassa esitetään erilaisia verkon rakenteeseen tai solmujen attribuutteihin perustuvia määritelmiä solmujen mielenkiintoisuudelle sekä useita menetelmiä mielenkiintoisten solmujen löytämiseksi. Mielenkiintoisuuden voi määritellä esim. merkityksellisyytenä suhteessa joihinkin annettuihin solmuihin ja toisaalta mielenkiintoisten solmujen keskinäisenä erilaisuutena. Esimerkiksi ns. ahneella menetelmällä voidaan löytää keskenään erilaisia solmuja yksi kerrallaan. Väitöskirjan tuloksia voidaan soveltaa esimerkiksi tekstiaineistoa käsittelemällä saatuun sanojen väliseen verkostoon, jossa kahden sanan välillä on sitä voimakkaampi yhteys mitä useammin ne tapaavat esiintyä keskenään samoissa lauseissa. Sanojen erilaisia käyttöyhteyksiä ja jopa merkityksiä voidaan nyt löytää automaattisesti. Jos kohdesanaksi otetaan vaikkapa "juuri", niin siihen liittyviä mutta keskenään toisiinsa liittymättömiä sanoja ovat "puu" (biologinen merkitys: kasvin juuri), "yhtälö" (matemaattinen merkitys: yhtälön ratkaisu eli juuri) sekä "indoeurooppalainen" (kielitieteellinen merkitys: sanan vartalo eli juuri). Tällaisia menetelmiä voidaan soveltaa esimerkiksi hakukoneessa: sanalla "juuri" tehtyihin hakutuloksiin sisällytetään tuloksia mahdollisimman erilaisista käyttöyhteyksistä, jotta käyttäjän tarkoittama merkitys tulisi todennäköisemmin katetuksi hakutuloksissa. Merkittävä sovelluskohde väitöskirjan menetelmille ovat biologiset verkot, joissa solmut edustavat biologisia käsitteitä (esim. geenejä, proteiineja tai sairauksia) ja kaaret niiden välisiä suhteita (esim. geeni koodaa proteiinia tai proteiini on aktiivinen tietyssä sairauksessa). Menetelmillä voidaan etsiä esimerkiksi sairauksiin vaikuttavia biologisia mekanismeja paikantamalla edustava joukko sairauteen ja siihen mahdollisesti liittyviin geeneihin verkostossa kytkeytyviä muita solmuja. Nämä voivat auttaa biologeja ymmärtämään geenien ja sairauden mahdollisia kytköksiä ja siten kohdentamaan jatkotutkimustaan lupaavimpiin geeneihin, proteiineihin tms. Väitöskirjassa esitetyt solmujen mielenkiintoisuuden määritelmät sekä niiden löytämiseen ehdotetut menetelmät ovat yleispäteviä ja niitä voi soveltaa periaatteessa mihin tahansa verkkoon riippumatta siitä, mitä solmut, kaaret tai painot edustavat. Kokeet erilaisilla verkoilla osoittavat että ne löytävät mielenkiintoisia solmuja

A formal architecture-centric and model driven approach for the engineering of science gateways

From n-Tier client/server applications, to more complex academic Grids, or even the most recent and promising industrial Clouds, the last decade has witnessed significant developments in distributed computing. In spite of this conceptual heterogeneity, Service-Oriented Architecture (SOA) seems to have emerged as the common and underlying abstraction paradigm, even though different standards and technologies are applied across application domains. Suitable access to data and algorithms resident in SOAs via so-called ‘Science Gateways’ has thus become a pressing need in order to realize the benefits of distributed computing infrastructures.In an attempt to inform service-oriented systems design and developments in Grid-based biomedical research infrastructures, the applicant has consolidated work from three complementary experiences in European projects, which have developed and deployed large-scale production quality infrastructures and more recently Science Gateways to support research in breast cancer, pediatric diseases and neurodegenerative pathologies respectively. In analyzing the requirements from these biomedical applications the applicant was able to elaborate on commonly faced issues in Grid development and deployment, while proposing an adapted and extensible engineering framework. Grids implement a number of protocols, applications, standards and attempt to virtualize and harmonize accesses to them. Most Grid implementations therefore are instantiated as superposed software layers, often resulting in a low quality of services and quality of applications, thus making design and development increasingly complex, and rendering classical software engineering approaches unsuitable for Grid developments.The applicant proposes the application of a formal Model-Driven Engineering (MDE) approach to service-oriented developments, making it possible to define Grid-based architectures and Science Gateways that satisfy quality of service requirements, execution platform and distribution criteria at design time. An novel investigation is thus presented on the applicability of the resulting grid MDE (gMDE) to specific examples and conclusions are drawn on the benefits of this approach and its possible application to other areas, in particular that of Distributed Computing Infrastructures (DCI) interoperability, Science Gateways and Cloud architectures developments

The Proceedings of the 23rd Annual International Conference on Digital Government Research (DGO2022) Intelligent Technologies, Governments and Citizens June 15-17, 2022

The 23rd Annual International Conference on Digital Government Research theme is “Intelligent Technologies, Governments and Citizens”. Data and computational algorithms make systems smarter, but should result in smarter government and citizens. Intelligence and smartness affect all kinds of public values - such as fairness, inclusion, equity, transparency, privacy, security, trust, etc., and is not well-understood. These technologies provide immense opportunities and should be used in the light of public values. Society and technology co-evolve and we are looking for new ways to balance between them. Specifically, the conference aims to advance research and practice in this field. The keynotes, presentations, posters and workshops show that the conference theme is very well-chosen and more actual than ever. The challenges posed by new technology have underscored the need to grasp the potential. Digital government brings into focus the realization of public values to improve our society at all levels of government. The conference again shows the importance of the digital government society, which brings together scholars in this field. Dg.o 2022 is fully online and enables to connect to scholars and practitioners around the globe and facilitate global conversations and exchanges via the use of digital technologies. This conference is primarily a live conference for full engagement, keynotes, presentations of research papers, workshops, panels and posters and provides engaging exchange throughout the entire duration of the conference