Integration of Data Mining and Data Warehousing: a practical methodology

The ever growing repository of data in all fields poses new challenges to the modern analytical systems. Real-world datasets, with mixed numeric and nominal variables, are difficult to analyze and require effective visual exploration that conveys semantic relationships of data. Traditional data mining techniques such as clustering clusters only the numeric data. Little research has been carried out in tackling the problem of clustering high cardinality nominal variables to get better insight of underlying dataset. Several works in the literature proved the likelihood of integrating data mining with warehousing to discover knowledge from data. For the seamless integration, the mined data has to be modeled in form of a data warehouse schema. Schema generation process is complex manual task and requires domain and warehousing familiarity. Automated techniques are required to generate warehouse schema to overcome the existing dependencies. To fulfill the growing analytical needs and to overcome the existing limitations, we propose a novel methodology in this paper that permits efficient analysis of mixed numeric and nominal data, effective visual data exploration, automatic warehouse schema generation and integration of data mining and warehousing. The proposed methodology is evaluated by performing case study on real-world data set. Results show that multidimensional analysis can be performed in an easier and flexible way to discover meaningful knowledge from large datasets

A Knowledge-based Integrative Modeling Approach for <em>In-Silico</em> Identification of Mechanistic Targets in Neurodegeneration with Focus on Alzheimer’s Disease

Dementia is the progressive decline in cognitive function due to damage or disease in the body beyond what might be expected from normal aging. Based on neuropathological and clinical criteria, dementia includes a spectrum of diseases, namely Alzheimer's dementia, Parkinson's dementia, Lewy Body disease, Alzheimer's dementia with Parkinson's, Pick's disease, Semantic dementia, and large and small vessel disease. It is thought that these disorders result from a combination of genetic and environmental risk factors. Despite accumulating knowledge that has been gained about pathophysiological and clinical characteristics of the disease, no coherent and integrative picture of molecular mechanisms underlying neurodegeneration in Alzheimer’s disease is available. Existing drugs only offer symptomatic relief to the patients and lack any efficient disease-modifying effects. The present research proposes a knowledge-based rationale towards integrative modeling of disease mechanism for identifying potential candidate targets and biomarkers in Alzheimer’s disease. Integrative disease modeling is an emerging knowledge-based paradigm in translational research that exploits the power of computational methods to collect, store, integrate, model and interpret accumulated disease information across different biological scales from molecules to phenotypes. It prepares the ground for transitioning from ‘descriptive’ to “mechanistic” representation of disease processes. The proposed approach was used to introduce an integrative framework, which integrates, on one hand, extracted knowledge from the literature using semantically supported text-mining technologies and, on the other hand, primary experimental data such as gene/protein expression or imaging readouts. The aim of such a hybrid integrative modeling approach was not only to provide a consolidated systems view on the disease mechanism as a whole but also to increase specificity and sensitivity of the mechanistic model by providing disease-specific context. This approach was successfully used for correlating clinical manifestations of the disease to their corresponding molecular events and led to the identification and modeling of three important mechanistic components underlying Alzheimer’s dementia, namely the CNS, the immune system and the endocrine components. These models were validated using a novel in-silico validation method, namely biomarker-guided pathway analysis and a pathway-based target identification approach was introduced, which resulted in the identification of the MAPK signaling pathway as a potential candidate target at the crossroad of the triad components underlying disease mechanism in Alzheimer’s dementia

When Wrong is Right: The Instructional Power of Multiple Conceptions

For many decades, educational communities, including computing education, have debated the value of telling students what they need to know (i.e., direct instruction) compared to guiding them to construct knowledge themselves (i.e., constructivism). Comparisons of these two instructional approaches have inconsistent results. Direct instruction can be more efficient for short-term performance but worse for retention and transfer. Constructivism can produce better retention and transfer, but this outcome is unreliable. To contribute to this debate, we propose a new theory to better explain these research results. Our theory, multiple conceptions theory, states that learners develop better conceptual knowledge when they are guided to compare multiple conceptions of a concept during instruction. To examine the validity of this theory, we used this lens to evaluate the literature for eight instructional techniques that guide learners to compare multiple conceptions, four from direct instruction (i.e., test-enhanced learning, erroneous examples, analogical reasoning, and refutation texts) and four from constructivism (i.e., productive failure, ambitious pedagogy, problem-based learning, and inquiry learning). We specifically searched for variations in the techniques that made them more or less successful, the mechanisms responsible, and how those mechanisms promote conceptual knowledge, which is critical for retention and transfer. To make the paper directly applicable to education, we propose instructional design principles based on the mechanisms that we identified. Moreover, we illustrate the theory by examining instructional techniques commonly used in computing education that compare multiple conceptions. Finally, we propose ways in which this theory can advance our instruction in computing and how computing education researchers can advance this general education theory

An Agent-Based Algorithm exploiting Multiple Local Dissimilarities for Clusters Mining and Knowledge Discovery

We propose a multi-agent algorithm able to automatically discover relevant regularities in a given dataset, determining at the same time the set of configurations of the adopted parametric dissimilarity measure yielding compact and separated clusters. Each agent operates independently by performing a Markovian random walk on a suitable weighted graph representation of the input dataset. Such a weighted graph representation is induced by the specific parameter configuration of the dissimilarity measure adopted by the agent, which searches and takes decisions autonomously for one cluster at a time. Results show that the algorithm is able to discover parameter configurations that yield a consistent and interpretable collection of clusters. Moreover, we demonstrate that our algorithm shows comparable performances with other similar state-of-the-art algorithms when facing specific clustering problems