Data Fusion by Matrix Factorization

For most problems in science and engineering we can obtain data sets that describe the observed system from various perspectives and record the behavior of its individual components. Heterogeneous data sets can be collectively mined by data fusion. Fusion can focus on a specific target relation and exploit directly associated data together with contextual data and data about system's constraints. In the paper we describe a data fusion approach with penalized matrix tri-factorization (DFMF) that simultaneously factorizes data matrices to reveal hidden associations. The approach can directly consider any data that can be expressed in a matrix, including those from feature-based representations, ontologies, associations and networks. We demonstrate the utility of DFMF for gene function prediction task with eleven different data sources and for prediction of pharmacologic actions by fusing six data sources. Our data fusion algorithm compares favorably to alternative data integration approaches and achieves higher accuracy than can be obtained from any single data source alone.Comment: Short preprint, 13 pages, 3 Figures, 3 Tables. Full paper in 10.1109/TPAMI.2014.234397

Tensor Analysis and Fusion of Multimodal Brain Images

Current high-throughput data acquisition technologies probe dynamical systems with different imaging modalities, generating massive data sets at different spatial and temporal resolutions posing challenging problems in multimodal data fusion. A case in point is the attempt to parse out the brain structures and networks that underpin human cognitive processes by analysis of different neuroimaging modalities (functional MRI, EEG, NIRS etc.). We emphasize that the multimodal, multi-scale nature of neuroimaging data is well reflected by a multi-way (tensor) structure where the underlying processes can be summarized by a relatively small number of components or "atoms". We introduce Markov-Penrose diagrams - an integration of Bayesian DAG and tensor network notation in order to analyze these models. These diagrams not only clarify matrix and tensor EEG and fMRI time/frequency analysis and inverse problems, but also help understand multimodal fusion via Multiway Partial Least Squares and Coupled Matrix-Tensor Factorization. We show here, for the first time, that Granger causal analysis of brain networks is a tensor regression problem, thus allowing the atomic decomposition of brain networks. Analysis of EEG and fMRI recordings shows the potential of the methods and suggests their use in other scientific domains.Comment: 23 pages, 15 figures, submitted to Proceedings of the IEE

Prompt photon hadroproduction at high energies in off-shell gluon-gluon fusion

The amplitude for production of a single photon associated with quark pair in the fusion of two off-shell gluons is calculated. The matrix element found is applied to the inclusive prompt photon hadroproduction at high energies in the framework of kt-factorization QCD approach. The total and differential cross sections are calculated in both central and forward pseudo-rapidity regions. The conservative error analisys is performed. We used the unintegrated gluon distributions in a proton which were obtained from the full CCFM evolution equation as well as from the Kimber-Martin-Ryskin prescription. Theoretical results were compared with recent experimental data taken by the D0 and CDF collaborations at Fermilab Tevatron. Theoretical predictions for the LHC energies are given.Comment: 32 pages, 18 figure

Improved Coupled Tensor Factorization with Its Applications in Health Data Analysis

© 2019 Qing Wu et al. Coupled matrix and tensor factorizations have been successfully used in many data fusion scenarios where datasets are assumed to be exactly coupled. However, in the real world, not all the datasets share the same factor matrices, which makes joint analysis of multiple heterogeneous sources challenging. For this reason, approximate coupling or partial coupling is widely used in real-world data fusion, with exact coupling as a special case of these techniques. However, to fully address the challenge of tensor factorization, in this paper, we propose two improved coupled tensor factorization methods: one for approximately coupled datasets and the other for partially coupled datasets. A series of experiments using both simulated data and three real-world datasets demonstrate the improved accuracy of these approaches over existing baselines. In particular, when experiments on MRI data is conducted, the performance of our method is improved even by 12.47% in terms of accuracy compared with traditional methods

Survival regression by data fusion

Any knowledge discovery could in principal benefit from the fusion of directly or even indirectly related data sources. In this paper we explore whether data fusion by simultaneous matrix factorization could be adapted for survival regression. We propose a new method that jointly infers latent data factors from a number of heterogeneous data sets and estimates regression coefficients of a survival model. We have applied the method to CAMDA 2014 large- scale Cancer Genomes Challenge and modeled survival time as a function of gene, protein and miRNA expression data, and data on methylated and mutated regions. We find that both joint inference of data factors and regression coefficients and data fusion procedure are crucial for performance. Our approach is substantially more accurate than the baseline Aalen’s additive model. Latent factors inferred by our approach could be mined further; for CAMDA challenge, we found that the most informative factors are related to known cancer processes