Fuzzy rough granular neural networks, fuzzy granules, and classification

AbstractWe introduce a fuzzy rough granular neural network (FRGNN) model based on the multilayer perceptron using a back-propagation algorithm for the fuzzy classification of patterns. We provide the development strategy of the network mainly based upon the input vector, initial connection weights determined by fuzzy rough set theoretic concepts, and the target vector. While the input vector is described in terms of fuzzy granules, the target vector is defined in terms of fuzzy class membership values and zeros. Crude domain knowledge about the initial data is represented in the form of a decision table, which is divided into subtables corresponding to different classes. The data in each decision table is converted into granular form. The syntax of these decision tables automatically determines the appropriate number of hidden nodes, while the dependency factors from all the decision tables are used as initial weights. The dependency factor of each attribute and the average degree of the dependency factor of all the attributes with respect to decision classes are considered as initial connection weights between the nodes of the input layer and the hidden layer, and the hidden layer and the output layer, respectively. The effectiveness of the proposed FRGNN is demonstrated on several real-life data sets

Water filtration by using apple and banana peels as activated carbon

Water filter is an important devices for reducing the contaminants in raw water. Activated from charcoal is used to absorb the contaminants. Fruit peels are some of the suitable alternative carbon to substitute the charcoal. Determining the role of fruit peels which were apple and banana peels powder as activated carbon in water filter is the main goal. Drying and blending the peels till they become powder is the way to allow them to absorb the contaminants. Comparing the results for raw water before and after filtering is the observation. After filtering the raw water, the reading for pH was 6.8 which is in normal pH and turbidity reading recorded was 658 NTU. As for the colour, the water becomes more clear compared to the raw water. This study has found that fruit peels such as banana and apple are an effective substitute to charcoal as natural absorbent

Machine learning and statistical techniques : an application to the prediction of insolvency in Spanish non-life insurance companies

Prediction of insurance companies insolvency has arisen as an important problem in the field of financial research. Most methods applied in the past to tackle this issue are traditional statistical techniques which use financial ratios as explicative variables. However, these variables often do not satisfy statistical assumptions, which complicates the application of the mentioned methods. In this paper, a comparative study of the performance of two non-parametric machine learning techniques (See5 and Rough Set) is carried out. We have applied the two methods to the problem of the prediction of insolvency of Spanish non-life insurance companies, upon the basis of a set of financial ratios. We also compare these methods with three classical and well-known techniques: one of them belonging to the field of Machine Learning (Multilayer Perceptron) and two statistical ones (Linear Discriminant Analysis and Logistic Regression). Results indicate a higher performance of the machine learning techniques. Furthermore, See5 and Rough Set provide easily understandable and interpretable decision models, which shows that these methods can be a useful tool to evaluate insolvency of insurance firms.El pronóstico sobre la insolvencia de las compañías de seguro ha surgido como un problema importante en el ámbito de investigación financiera. La mayoría de los métodos aplicados en el pasado para abordar este problema, son técnicas estadísticas tradicionales que usan los ratios financieros como variables explicativas. Aunque, estas variables a menudo no satisfacen las suposiciones estadísticas, lo que complica la aplicación de dichos métodos. En este artículo, se lleva a cabo un estudio comparativo sobre la actuación de dos técnicas de aprendizaje automático no paramétrico (See5 y Rough Set). Hemos aplicado ambos métodos al problema del pronóstico sobre la insolvencia de compañías españolas de seguros no de vida, sobre la base de un conjunto de ratios financieros. Además, hemos comparado estos métodos con tres técnicas clásicas y muy conocidas: una de ellas perteneciente al área del Aprendizaje Automático (Perceptrón Multicapa), y dos estadísticos (Análisis Discriminante Lineal y Regresión Logística). Los resultados indican un desempeño más elevado en las técnicas de aprendizaje automático. Es más, See5 y Rough Set aportan unos modelos de decisión fácilmente entendibles, e interpretables, lo que demuestra que estos métodos pueden ser útiles para evaluar la insolvencia de empresas de seguros

Evaluating Microarray-based Classifiers: An Overview

For the last eight years, microarray-based class prediction has been the subject of numerous publications in medicine, bioinformatics and statistics journals. However, in many articles, the assessment of classification accuracy is carried out using suboptimal procedures and is not paid much attention. In this paper, we carefully review various statistical aspects of classifier evaluation and validation from a practical point of view. The main topics addressed are accuracy measures, error rate estimation procedures, variable selection, choice of classifiers and validation strategy

Microarray-Based Cancer Prediction Using Soft Computing Approach

One of the difficulties in using gene expression profiles to predict cancer is how to effectively select a few informative genes to construct accurate prediction models from thousands or ten thousands of genes. We screen highly discriminative genes and gene pairs to create simple prediction models involved in single genes or gene pairs on the basis of soft computing approach and rough set theory. Accurate cancerous prediction is obtained when we apply the simple prediction models for four cancerous gene expression datasets: CNS tumor, colon tumor, lung cancer and DLBCL. Some genes closely correlated with the pathogenesis of specific or general cancers are identified. In contrast with other models, our models are simple, effective and robust. Meanwhile, our models are interpretable for they are based on decision rules. Our results demonstrate that very simple models may perform well on cancerous molecular prediction and important gene markers of cancer can be detected if the gene selection approach is chosen reasonably

A Rough Set-Based Model of HIV-1 Reverse Transcriptase Resistome

Reverse transcriptase (RT) is a viral enzyme crucial for HIV-1 replication. Currently, 12 drugs are targeted against the RT. The low fidelity of the RT-mediated transcription leads to the quick accumulation of drug-resistance mutations. The sequence-resistance relationship remains only partially understood. Using publicly available data collected from over 15 years of HIV proteome research, we have created a general and predictive rule-based model of HIV-1 resistance to eight RT inhibitors. Our rough set-based model considers changes in the physicochemical properties of a mutated sequence as compared to the wild-type strain. Thanks to the application of the Monte Carlo feature selection method, the model takes into account only the properties that significantly contribute to the resistance phenomenon. The obtained results show that drug-resistance is determined in more complex way than believed. We confirmed the importance of many resistance-associated sites, found some sites to be less relevant than formerly postulated and—more importantly—identified several previously neglected sites as potentially relevant. By mapping some of the newly discovered sites on the 3D structure of the RT, we were able to suggest possible molecular-mechanisms of drug-resistance. Importantly, our model has the ability to generalize predictions to the previously unseen cases. The study is an example of how computational biology methods can increase our understanding of the HIV-1 resistome

Revealing cell cycle control by combining model-based detection of periodic expression with novel cis-regulatory descriptors

<p>Abstract</p> <p>Background</p> <p>We address the issue of explaining the presence or absence of phase-specific transcription in budding yeast cultures under different conditions. To this end we use a model-based detector of gene expression periodicity to divide genes into classes depending on their behavior in experiments using different synchronization methods. While computational inference of gene regulatory circuits typically relies on expression similarity (clustering) in order to find classes of potentially co-regulated genes, this method instead takes advantage of known time profile signatures related to the studied process.</p> <p>Results</p> <p>We explain the regulatory mechanisms of the inferred periodic classes with <it>cis</it>-regulatory descriptors that combine upstream sequence motifs with experimentally determined binding of transcription factors. By systematic statistical analysis we show that periodic classes are best explained by combinations of descriptors rather than single descriptors, and that different combinations correspond to periodic expression in different classes. We also find evidence for additive regulation in that the combinations of <it>cis</it>-regulatory descriptors associated with genes periodically expressed in fewer conditions are frequently subsets of combinations associated with genes periodically expression in more conditions. Finally, we demonstrate that our approach retrieves combinations that are more specific towards known cell-cycle related regulators than the frequently used clustering approach.</p> <p>Conclusion</p> <p>The results illustrate how a model-based approach to expression analysis may be particularly well suited to detect biologically relevant mechanisms. Our new approach makes it possible to provide more refined hypotheses about regulatory mechanisms of the cell cycle and it can easily be adjusted to reveal regulation of other, non-periodic, cellular processes.</p