Whole genome sequencing of foodborne pathogens and global data sharing development

With the rapid development of molecular typing techniques for monitoring foodborne pathogens and outbreak investigations, whole genome sequencing (WGS) is gradually revealing its importance. In the context of the globalization of food trade, it’s urgent to establish details of the links between foodborne pathogens and human exposure in order to accurately monitor and reduce their occurrence. The accuracy of WGS is significantly better than prior analysis tools in the aspect. In this paper, we take Listeria monocytogenes as example to expound the monitoring of foodborne pathogens and the investigation of infection outbreaks, emphasizing the value of WGS in trace-back of foodborne diseases. The technologies for data generation and analysis are summarized, the practical application progress of WGS in the worldwide foodborne pathogen typing is emphasized, and the challenges in the future are prospected

Reflections and explorations on deep earth science and deep earth engineering technology

Deep earth science in the 21st century has entered a new stage of development. The laws of deep earth science have not yet been explored. Deep engineering activities generally have a certain degree of blindness, inefficiency and uncertainty, and the endogenous dynamics of the Earth’s deep part, structural evolutionary laws, and disaster-causing mechanisms need to be further cognised. Therefore, this paper firstly defines deep earth science from the perspective of geoscience: the deep and ultra-deep layers of the earth are the research objects from the shallow earth to the deep, aiming at exploring the scientific mysteries of the earth’s different layers and different depths of the earth (deep and ultra-deep); clarifies the difference and connection between the deep earth science and the earth science: that is to say, the deep earth science is an extension of the known knowledge system of the earth science, and it is the national strategic science and technology direction to expand the scientific horizons, and to deepen the earth’s cognition. It is a national strategic scientific and technological direction to expand scientific vision and deepen earth knowledge, which is included in earth science; it defines the essence of deep and deep earth engineering science: that is, for the difficulties that the existing scientific laws and technologies of shallow engineering cannot be applied to deep engineering, it is necessary to explore the relevant scientific laws of deep engineering, break through the key basic scientific problems of deep engineering, and meet the demand for geo-disaster prevention and control of human beings in the activities of deep engineering, and then guide the safe, efficient, and green development of deep resources and effective utilization of the space of deep engineering; at the same time, it further clarifies the difference and connection between deep earth science and earth science. This article proposes the definition of deep earth engineering technology, which refers to the engineering implementation technology and equipment required by humans to utilize and develop the Earth, as well as the necessary theoretical and technical means to explore the laws of deep earth science and develop deep earth engineering. Finally, to promote the development of deep earth science, the research content and strategic planning of deep earth science, and the connotation of deep earth engineering technology, have been further clarified (geomechanics and disaster mechanism of deep-earth engineering, intelligent construction and efficient mining, intelligent construction of deep-earth tunnels and giant cavern groups, intelligent disaster prevention and control as well as healthy operation and maintenance of deep-earth engineering)

Research progress on preparation and physicochemical properties of coal-based graphene quantum dots

Graphene quantum dots (GQDs) have attracted great research interest due to their remarkable quantum confinement and edge effects. In addition to exhibiting stable photoluminescence, it also has many advantages such as low cytotoxicity, good solubility and chemical inertness, making it widely used in bioimaging, photocatalysts and sensors. The industrial development of GQDs has been seriously hampered by the expensive raw materials and tedious operation of traditional preparation methods. Coal and its derivatives not only possess the characteristics of low price and abundant reserves, but also show greater advantages than graphite, graphene, graphite oxide and other carbon materials in the preparation of GQDs due to its inherent internal disorder structure and small crystal domain. GQDs can be prepared by simply stripping the aromatic ring clusters inside the coal and its derivatives through physical, chemical or electrochemical methods. This review first summarizes the “top-down” synthesis method of coal-based graphene quantum dots (C-GQDs) and its pros and cons. Then the structural morphology, chemical composition, fluorescence properties of C-GQDs and their influencing factors are analyzed. Further, we describe the progress in applications of C-GQDs in fields such as sensors, bioimaging and energy Finally, the future development of C-GQDs is discussed from the perspectives of preparation methods, carbon source selection and research directions, and the following experimental schemes are proposed: (1) Experiment with H2O2 as oxidizer and thermally altered coals as carbon sources； (2) Experiments other than oxidation with sulfuric acid and nitric acid using superhigh organic sulfur coals as carbon sources； (3) Experiment on coal macerals as a carbon sources. In addition, the combination of experimentally derived basic data and computer simulation technology can solve the problems of current research such as single fluorescence color and low quantum yield. The goals of clean utilization of coal resources and green development of GQDs have been achieved

Composition, Molecular Structure, Binding,Stability, and Inducing Apoptosis of Tumor Cellswith Tea Polyphenol-Manganese

茶多酚(TP)具有多种生物活性，尤其在预防癌症和抗肿瘤作用较为明显，具有开发抗肿瘤药物的价值。茶多酚主要由儿茶素及酚类化合物组成，儿茶素主要有(-)表没食儿茶素没食子酸（EGCG）、(-)表没食儿茶素没食子棓酸甲酯（EGCMG）和表三羟基黄烷-3-醇没食子酸酯（EZG）等。这些多酚化合物均能与Mn2+和Ge4+反应且形成含锰或锗的酚类化合物，表现出茶多酚锰/锗的特殊理化特性及生物活性。本论文采用有机合成法合成茶多酚锰（TP-Mn）、茶多酚锗(TP-Ge)。选用红外光谱法、ESI-Q-TOF技术表征茶多酚锰（TP-Mn）的理化特性。选用凝胶高效液相色谱（GP-HPLC）和电感藕合等离子体质谱(I...Tea Polyphenols (TP) has great value as an anticancer drug in the future, due to its various biological activities, especially in the prevention of human cancer and the effects of anticancer. The main components of TP are catechins and multiphenolic compounds. Epigallo-catechin gallate (EGCG), EGCMG and EZG, etc are the major compounds of catechins. They also show the ability for binding to heavy ...学位：理学硕士院系专业：生命科学学院生物化学与生物技术系_生物化学与分子生物学学号：K20014502

Application Progress of Oilomics Research in Human Nutrition and Health Research

Edible oils and fats are the important dietary nutrients for human body, and play a vital roles in maintaining nutritional health for the hosts. Whereas, the unhealthy oils and fats intake would lead to the increase of the risks of chronic metabolic diseases, which has become a serious public health challenge for the present society. The oilomics, integrating genomics, transcriptomics, proteomics, metabolomics, lipomics as the major analytical methods, have been becoming on important approach to elucidate the host nutritional and metabolic regulation mechanisms, and realize the personalized nutrition of human body based on the functional characteristics of dietary factors. The present review manuscript illustrated the basic concepts of oilomics, and the major research approaches of oilomics in the areas of edible oil nutrition and human health. Moreover, the research progress of oilomics in oil nutrition and host health research were also summarized, primarily, focusing on elaborating the nutrients metabolic regulation, the enteral nutrition and gut homeostasis, as well as the personalized nutrition of the humans. In view of the current research status, the future trends of the development of oilomics were further prospected, at the aim of which is to provide references for expanding the applications of oilomics in lipid nutrition and human health. The overall nutrition level of the nationwide residents will be improved, and the construction of healthy China will be promoted

Overseas Chinese Environmental Engineers and Scientists Association (OCEESA) Report, Regular Issue, February 2020

This OCEESA report, which is regular issue of OCEESA Journal (Overseas Chinese Environmental Engineers and Scientists Association Journal). This report is OCEESA report number: OCEESA/JL-2020/3701, February 2020, ISSN 1072 -7248. This report is also OCEESA Journal, Volume 37, Number 1, February 2020. Yung-Tse Hung, Permanent Executive Director, OCEESA, is editor of this report. This issue includes: (A) 10 OCEESA Best Papers (B) 6 OCEESA Papers; 21.Zhang-Zhi Charlie Huang 黄长志 , Implementing Compensation System for Environmental Damages: Challenges and Solutions, 22. Hanlu Yan, Kaimin Shih施凱閔 , Quantitative X-Ray Diffraction for Characterizing P Recovery Products from Wastewater, 23. Kaimin Shih 施凱閔 , Material Mineralogical Technology for Pollution Prevention and Resource Recovery材料礦物學技術於污染防治與資源回收的應用, 24. Kuo-Kunag Hsu 許國光 , Cleanup of MSW-Gasified Synthesis Gas, 25. Pao-Chiang Yuan 袁保強 , End of Useful Life Computer Recycling Program at Jackson State University, Jackson, Mississippi, USA, 26. Qin Qian钱琴, Bo Sun, Xianchang Li, Frank Sun, Che-Jen Lin, Water quality modeling with data collected by wireless sensor networks (WSNs) in an experimental pond: A case study; (C) 3 technical papers; 28. Abdulkarim Alorayfij, Yung-Tse Hung, Anaerobic digestion of agricultural waste, 29. Abdullah Alshati, Yung-Tse Hung, Methane Gas Production from Animal Waste, 30. Abdulmajeed Alshatti, Yung-Tse Hung, Treatment of Timber Industry Wastes, 31. OCEESA Constitutions By-Laws (5 November 2000 edition), 32. OCEESA Constitutions By-Laws (14 February 2006 edition), 33. OCEESA Constitutions By-Laws (27 October 2013 edition), 34. Lawrence Kong-Pu Wang letter of support Yung-Tse Hung Permanent Executive Director OCEESA 12-30-20, 35. Wen-Chi Ku letter of support Yung-Tse Hung Permanent Executive Director OCEESA 12-03-20, 36. OCEESA Member Application Form and Information, 37. Mailing Address Pag