Fault-tolerance techniques for hybrid CMOS/nanoarchitecture

The authors propose two fault-tolerance techniques for hybrid CMOS/nanoarchitecture implementing logic functions as look-up tables. The authors compare the efficiency of the proposed techniques with recently reported methods that use single coding schemes in tolerating high fault rates in nanoscale fabrics. Both proposed techniques are based on error correcting codes to tackle different fault rates. In the first technique, the authors implement a combined two-dimensional coding scheme using Hamming and Bose-Chaudhuri-Hocquenghem (BCH) codes to address fault rates greater than 5. In the second technique, Hamming coding is complemented with bad line exclusion technique to tolerate fault rates higher than the first proposed technique (up to 20). The authors have also estimated the improvement that can be achieved in the circuit reliability in the presence of Don-t Care Conditions. The area, latency and energy costs of the proposed techniques were also estimated in the CMOS domain

The opposites task: Using general rules to test cognitive flexibility in preschoolers

A brief narrative description of the journal article, document, or resource. Executive functions play an important role in cognitive development, and during the preschool years especially, children's performance is limited in tasks that demand flexibility in their behavior. We asked whether preschoolers would exhibit limitations when they are required to apply a general rule in the context of novel stimuli on every trial (the "opposites" task). Two types of inhibitory processing were measured: response interference (resistance to interference from a competing response) and proactive interference (resistance to interference from a previously relevant rule). Group data show 3-year-olds have difficulty inhibiting prepotent tendencies under these conditions, whereas 5-year-olds' accuracy is near ceiling in the task. (Contains 4 footnotes and 1 table.

Dissemination of Mycobacterium abscessus via global transmission networks.

Mycobacterium abscessus, a multidrug-resistant nontuberculous mycobacterium, has emerged as a major pathogen affecting people with cystic fibrosis (CF). Although originally thought to be acquired independently from the environment, most individuals are infected with one of several dominant circulating clones (DCCs), indicating the presence of global transmission networks of M. abscessus. How and when these clones emerged and spread globally is unclear. Here, we use evolutionary analyses of isolates from individuals both with and without CF to reconstruct the population history, spatiotemporal spread and recent transmission networks of the DCCs. We demonstrate synchronous expansion of six unrelated DCCs in the 1960s, a period associated with major changes in CF care and survival. Each of these clones has spread globally as a result of rare intercontinental transmission events. We show that the DCCs, but not environmentally acquired isolates, exhibit a specific smoking-associated mutational signature and that current transmission networks include individuals both with and without CF. We therefore propose that the DCCs initially emerged in non-CF populations but were then amplified and spread through the CF community. While individuals with CF are probably the most permissive host, non-CF individuals continue to play a key role in transmission networks and may facilitate long-distance transmission.Funding for this work was provided by The Wellcome Trust (investigator award no. 107032/Z/15/Z to R.A.F.), Fondation Botnar (Programme grant no. 6063) and the UK CF Trust (Innovation Hub award no. 001; Strategic Research Centre award no. 010). M.S., N.A.H. and R.M.D. acknowledge the Cystic Fibrosis Foundation for funding

Positive Affect Facilitates Task Switching in the Dimension Change Card Sort Task: Implications for the Shifting Aspect of Executive Functions

Ministry of Education, Singapore under its Academic Research Funding Tier 1; Singapore Management Universit

Evaluating the Impacts of Driver Behavior in the Speed Selection Process and the Related Outcomes

In the United States, traffic crashes claim the lives of 30,000 people every year and is the leading cause of death for 5-24 year olds. Driver error is the leading factor in over 90 percent of motor vehicle crashes, with the roadway and the vehicle each only accounting for about 2 percent of crashes. In the United States, nearly a third of fatal crashes are due to speeding and therefore, a critical step in improving traffic safety is research aimed to reduce speeding, such as crash data analysis, outreach campaigns, targeted enforcement, and understanding speed selection. In this dissertation, a multi-faceted approach was taken to improve roadway safety by examining the speeding-related crash designation, improving speed limit setting practices, and understanding the causes of speeding. Multiple experiments were conducted under this overarching goal. These experiments included an analysis of speeding-related crashes in Massachusetts, a naturalistic driving study, and a driving simulator study which investigated the causes of speeding. Collectively, the findings from these experiments can expand upon existing speed prediction models, improve crash data influence speed limit setting practices, guide speed management programs such as speed enforcement, and be used in public safety outreach campaigns

Cognitive and neural underpinnings of goal maintenance in young children

Active maintenance of goal representations is an integral part of our mental regulatory processes. Previous developmental studies have highlighted goal neglect, which is the phenomenon caused by a failure to maintain goal representations, and demonstrated developmental changes of the ability to maintain goal representations among preschoolers. Yet, few studies have explored the cognitive mechanisms underlying preschoolers' development of goal maintenance. The first aim of this study was to test whether working memory capacity and inhibitory control contribute to goal maintenance using a paradigm for measuring goal neglect. Moreover, although recent studies have shown that preschoolers recruit lateral prefrontal regions in performing executive functions tasks, they could not specify the neural underpinnings of goal maintenance. Thus, the second aim was to examine whether lateral prefrontal regions played a key role in maintaining goal representations using functional near-infrared spectroscopy. Our results showed that developmental differences in inhibitory control predicted the degree of goal neglect. It was also demonstrated that activation in the right prefrontal region was associated with children's successful avoidance of goal neglect. These findings offer important insights into the cognitive and neural underpinnings of goal maintenance in preschoolers

Impact of drug discount contracts on pharmacies and on patients' drug supply

Since April 2007, health insurance companies in Germany have been entitled to negotiate drug discount contracts (DDCs) with pharmaceutical manufacturers for particular drugs. DDCs commit pharmacists to dispense the drug made by this manufacturer. The aim of this study was to examine how DDCs are implemented in pharmacy routines and what implications DDCs have for the everday drug supply. Methods: A standardized questionnaire on DDCs and their impact on the drug supply was developed according to the previous literature, piloted and distributed to pharmacies in Baden-Württemberg. Results: Eight hundred four pharmacists and pharmaceutical assistants participated in the study. The implementation of DDCs implies significant extra work for pharmacists, particulary the additional need for customer counseling and education (99.1%), additional logistical requirements and more complex data processing needs. Patients are reported to get confused (97%) and angry (96.9%) about non-transparent drug substitutions, and medication errors occur (60.1%). Conclusion: DDCs, besides having implications for prescibers and patients, also have a substantial impact on pharmacists and pharmacies. Adverse effects on the drug supply and medication safety are possible or likely