Optimal exact designs of experiments via Mixed Integer Nonlinear Programming

Optimal exact designs are problematic to find and study because there is no unified theory for determining them and studyingtheir properties. Each has its own challenges and when a method exists to confirm the design optimality, it is invariablyapplicable to the particular problem only.We propose a systematic approach to construct optimal exact designs by incorporatingthe Cholesky decomposition of the Fisher Information Matrix in a Mixed Integer Nonlinear Programming formulation. Asexamples, we apply the methodology to find D- and A-optimal exact designs for linear and nonlinear models using global orlocal optimizers. Our examples include design problems with constraints on the locations or the number of replicates at theoptimal design points

A binarisation heuristic for non-convex quadratic programming with box constraints

Non-convex quadratic programming with box constraints is a fundamental problem in the global optimization literature, being one of the simplest NP-hard nonlinear programs. We present a new heuristic for this problem, which enables one to obtain solutions of excellent quality in reasonable computing times. The heuristic consists of four phases: binarisation, convexification, branch-and-Bound, and local optimisation. Some very encouraging computational results are given

Mathematical Programming Decoding of Binary Linear Codes: Theory and Algorithms

Mathematical programming is a branch of applied mathematics and has recently been used to derive new decoding approaches, challenging established but often heuristic algorithms based on iterative message passing. Concepts from mathematical programming used in the context of decoding include linear, integer, and nonlinear programming, network flows, notions of duality as well as matroid and polyhedral theory. This survey article reviews and categorizes decoding methods based on mathematical programming approaches for binary linear codes over binary-input memoryless symmetric channels.Comment: 17 pages, submitted to the IEEE Transactions on Information Theory. Published July 201