Evoked Potentials and Their Applications in Cardiac Arrest, Prosthetic Feedback, and Focused Ultrasound

The hypoxic-ischemic (HI) brain injury is a major complication after cardiac arrest (CA). While the HI brain injury affects all regions of the brain, the majority of the studies have focused on the injury of the cerebral cortex and the hippocampus. The thalamus is an important subcortical structure due to its functions in sensation, sleep, attention, and arousal, and has been shown to be selectively vulnerable to HI injury. Despite the importance of the thalamus, there does not exists a translatable quantitative metric of thalamic injury after CA. Thus, this thesis focuses on studying thalamic injury after CA using somatosensory evoked potentials (SSEPs). The thesis first reviews past studies on thalamic blood flow, metabolism, immune response, cell damage, and electrophysiology change after CA to paint a full picture of the problem. The existing quantitative metrics of somatosensory evoked potentials to evaluate the integrity of the somatosensory pathway after CA are then reported to identify potential areas for breakthrough. Lastly, our current work on noninvasive monitoring of thalamocortical (TC) connectivity with wavelet filtering and Granger causality (GC) analysis is presented. Multiresolution wavelet (MRW) analysis extracted the SSEP N10 and high-frequency oscillation (HFO) components. The Granger causality between the two components were calculated. The results show that the HFO to N10 GC measure could reflect the severity of CA and highlights the first 10 minutes post-return of spontaneous circulation (ROSC) as the critical period for TC dissociation intervention. In the last two parts of the thesis, additional projects utilizing evoked potentials to study the ultrasound neuromodulation effect on the spinal cord and the cognitive limitations of prosthetic sensory feedback were also reported. These works are documented for archiving purposes and enlightening readers on the broad spectrum of evoked potential applications. Motor evoked potential amplitudes were suppressed during low-frequency focused ultrasound (LIFUS) modulation and gradually recovered after modulation. The future goal of this project is to use focused ultrasound to inhibit TC neurons and to increase TC association in the acute phase of recovery after cardiac arrest. P300 event-related potential is commonly associated with the subject's level of confidence about the category of a stimulus. When a new sensory feedback intensity was introduced, no different in force level was found, but the higher P300 amplitude in response to the novel sensory stimulation showed that the brain were able to recognize the new stimulation level. This work provides evidence that the upper limit of prosthetic sensory feedback level should be more than just three levels

Aberrant Modulation of Brain Oscillatory Activity and Attentional Impairment in Attention-Deficit/Hyperactivity Disorder

Electroencephalography and magnetoencephalography are noninvasive neuroimaging techniques that have been used extensively to study various resting-state and cognitive processes in the brain. The purpose of this review is to highlight a number of recent studies that have investigated the alpha band (8-12 Hz) oscillatory activity present in magnetoencephalography and electroencephalography, to provide new insights into the maladaptive network activity underlying attentional impairments in attention-deficit/hyperactivity disorder (ADHD). Studies reviewed demonstrate that event-related decrease in alpha is attenuated during visual selective attention, primarily in ADHD inattentive type, and is often significantly associated with accuracy and reaction time during task performance. Furthermore, aberrant modulation of alpha activity has been reported across development and may have abnormal or atypical lateralization patterns in ADHD. Modulations in the alpha band thus represent a robust, relatively unexplored putative biomarker of attentional impairment and a strong prospect for future studies aimed at examining underlying neural mechanisms and treatment response among individuals with ADHD. Potential limitations of its use as a diagnostic biomarker and directions for future research are discussed

A model for cerebral cortical neuron group electric activity and its implications for cerebral function

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2002.Includes bibliographical references (p. 245-265).The electroencephalogram, or EEG, is a recording of the field potential generated by the electric activity of neuronal populations of the brain. Its utility has long been recognized as a monitor which reflects the vigilance states of the brain, such as arousal, drowsiness, and sleep stages. Moreover, it is used to detect pathological conditions such as seizures, to calibrate drug action during anesthesia, and to understand cognitive task signatures in healthy and abnormal subjects. Being an aggregate measure of neural activity, understanding the neural origins of EEG oscillations has been limited. With the advent of recording techniques, however, and as an influx of experimental evidence on cellular and network properties of the neocortex has become available, a closer look into the neuronal mechanisms for EEG generation is warranted. Accordingly, we introduce an effective neuronal skeleton circuit at a neuronal group level which could reproduce basic EEG-observable slow ( 3mm). The effective circuit makes use of the dynamic properties of the layer 5 network to explain intra-cortically generated augmenting responses, restful alpha, slow wave (< 1Hz) oscillations, and disinhibition-induced seizures. Based on recent cellular evidence, we propose a hierarchical binding mechanism in tufted layer 5 cells which acts as a controlled gate between local cortical activity and inputs arriving from distant cortical areas. This gate is manifested by the switch in output firing patterns in tufted(cont.) layer 5 cells between burst firing and regular spiking, with specific implications on local functional connectivity. This hypothesized mechanism provides an explanation of different alpha band (10Hz) oscillations observed recently under cognitive states. In particular, evoked alpha rhythms, which occur transiently after an input stimulus, could account for initial reogranization of local neural activity based on (mis)match between driving inputs and modulatory feedback of higher order cortical structures, or internal expectations. Emitted alpha rhythms, on the other hand, is an example of extreme attention where dominance of higher order control inputs could drive reorganization of local cortical activity. Finally, the model makes predictions on the role of burst firing patterns in tufted layer 5 cells in redefining local cortical dynamics, based on internal representations, as a prelude to high frequency oscillations observed in various sensory systems during cognition.by Fadi Nabih Karameh.Ph.D

Influence of deep structures on the EEG and their invasive and non-invasive assessment

Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Fisiología, leída el 22-11-2019El EEG es la prueba diagnóstica de mayor utilidad en el diagnóstico de la epilepsia. Consiste esencialmente en la representación gráfica de los potenciales postsinápticos generados en las neuronas piramidales de la corteza. Los campos eléctricos registrados en la superficie tienen principalmente dos mecanismos de origen: conducción de volumen desde regiones adyacentes y propagación interneuronal sináptica. Las neuronal piramidales se agrupan formando microcircuitos locales siendo estos circuitos los responsables de la generación delos ritmos registrados en el EEG. Uno de los principales retos de la electroencefalografía consiste en descifrar la relación entre la actividad registrada y la actividad subyacente en las redes neuronales. Para encontrar la fuente de dichas actividades, es necesario tener en cuenta complejos mecanismos tanto no lineales como lineales, así como el efecto de la conducción de volumen y la influencia de la morfología y las propiedades eléctricas del cerebro y el cráneo. Además, las regiones cerebrales se encuentran profusamente interconectadas a menudo produciendo una modulación recíproca que añade un mayor grado complejidad...The EEG is the most valuable diagnostic test in epilepsy. In essence, it mainly consists in agraphical representation of the summated postsynaptic potentials generated in the pyramidal neurons from the cortex. The electrical fields can be generated on the scalp by two mechanisms: volume conduction from nearby regions and synaptic inter‐neuronal propagation. Pyramidal cells align conforming local microcircuit configurations which activation lead to the generation of EEG rhythms. One of the main challenges of EEG is to decipher the relation between the recorded EEG activity and the activity in the neuronal networks. To find the source of EEG activity, complex non‐linear and linear mechanisms as well as volume conduction effect and influence of the shape and electrical properties of the brain and skull need to be taken in consideration. In addition, brain regions are profusely interconnected and functionally connected regions often produce mutual modulation that adds additional complexity...Depto. de FisiologíaFac. de MedicinaTRUEunpu