10,460 research outputs found
A multimodal neuroimaging classifier for alcohol dependence
With progress in magnetic resonance imaging technology and a broader dissemination of state-of-the-art imaging facilities, the acquisition of multiple neuroimaging modalities is becoming increasingly feasible. One particular hope associated with multimodal neuroimaging is the development of reliable data-driven diagnostic classifiers for psychiatric disorders, yet previous studies have often failed to find a benefit of combining multiple modalities. As a psychiatric disorder with established neurobiological effects at several levels of description, alcohol dependence is particularly well-suited for multimodal classification. To this aim, we developed a multimodal classification scheme and applied it to a rich neuroimaging battery (structural, functional task-based and functional resting-state data) collected in a matched sample of alcohol-dependent patients (N = 119) and controls (N = 97). We found that our classification scheme yielded 79.3% diagnostic accuracy, which outperformed the strongest individual modality - grey-matter density - by 2.7%. We found that this moderate benefit of multimodal classification depended on a number of critical design choices: a procedure to select optimal modality-specific classifiers, a fine-grained ensemble prediction based on cross-modal weight matrices and continuous classifier decision values. We conclude that the combination of multiple neuroimaging modalities is able to moderately improve the accuracy of machine-learning-based diagnostic classification in alcohol dependence
A multimodal neuroimaging classifier for alcohol dependence
With progress in magnetic resonance imaging technology and a broader dissemination of state-of-the-art imaging facilities, the acquisition of multiple neuroimaging modalities is becoming increasingly feasible. One particular hope associated with multimodal neuroimaging is the development of reliable data-driven diagnostic classifiers for psychiatric disorders, yet previous studies have often failed to find a benefit of combining multiple modalities. As a psychiatric disorder with established neurobiological effects at several levels of description, alcohol dependence is particularly well-suited for multimodal classification. To this aim, we developed a multimodal classification scheme and applied it to a rich neuroimaging battery (structural, functional task-based and functional resting-state data) collected in a matched sample of alcohol-dependent patients (N = 119) and controls (N = 97). We found that our classification scheme yielded 79.3% diagnostic accuracy, which outperformed the strongest individual modality - grey-matter density - by 2.7%. We found that this moderate benefit of multimodal classification depended on a number of critical design choices: a procedure to select optimal modality-specific classifiers, a fine-grained ensemble prediction based on cross-modal weight matrices and continuous classifier decision values. We conclude that the combination of multiple neuroimaging modalities is able to moderately improve the accuracy of machine-learning-based diagnostic classification in alcohol dependence
Security Evaluation of Support Vector Machines in Adversarial Environments
Support Vector Machines (SVMs) are among the most popular classification
techniques adopted in security applications like malware detection, intrusion
detection, and spam filtering. However, if SVMs are to be incorporated in
real-world security systems, they must be able to cope with attack patterns
that can either mislead the learning algorithm (poisoning), evade detection
(evasion), or gain information about their internal parameters (privacy
breaches). The main contributions of this chapter are twofold. First, we
introduce a formal general framework for the empirical evaluation of the
security of machine-learning systems. Second, according to our framework, we
demonstrate the feasibility of evasion, poisoning and privacy attacks against
SVMs in real-world security problems. For each attack technique, we evaluate
its impact and discuss whether (and how) it can be countered through an
adversary-aware design of SVMs. Our experiments are easily reproducible thanks
to open-source code that we have made available, together with all the employed
datasets, on a public repository.Comment: 47 pages, 9 figures; chapter accepted into book 'Support Vector
Machine Applications
A Stable Multi-Scale Kernel for Topological Machine Learning
Topological data analysis offers a rich source of valuable information to
study vision problems. Yet, so far we lack a theoretically sound connection to
popular kernel-based learning techniques, such as kernel SVMs or kernel PCA. In
this work, we establish such a connection by designing a multi-scale kernel for
persistence diagrams, a stable summary representation of topological features
in data. We show that this kernel is positive definite and prove its stability
with respect to the 1-Wasserstein distance. Experiments on two benchmark
datasets for 3D shape classification/retrieval and texture recognition show
considerable performance gains of the proposed method compared to an
alternative approach that is based on the recently introduced persistence
landscapes
Soft Methodology for Cost-and-error Sensitive Classification
Many real-world data mining applications need varying cost for different
types of classification errors and thus call for cost-sensitive classification
algorithms. Existing algorithms for cost-sensitive classification are
successful in terms of minimizing the cost, but can result in a high error rate
as the trade-off. The high error rate holds back the practical use of those
algorithms. In this paper, we propose a novel cost-sensitive classification
methodology that takes both the cost and the error rate into account. The
methodology, called soft cost-sensitive classification, is established from a
multicriteria optimization problem of the cost and the error rate, and can be
viewed as regularizing cost-sensitive classification with the error rate. The
simple methodology allows immediate improvements of existing cost-sensitive
classification algorithms. Experiments on the benchmark and the real-world data
sets show that our proposed methodology indeed achieves lower test error rates
and similar (sometimes lower) test costs than existing cost-sensitive
classification algorithms. We also demonstrate that the methodology can be
extended for considering the weighted error rate instead of the original error
rate. This extension is useful for tackling unbalanced classification problems.Comment: A shorter version appeared in KDD '1
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