A Computational Method for the Image Segmentation of Pigmented Skin Lesions

Senior Project submitted to The Division of Science, Mathematics and Computing of Bard College

Computational methods for the image segmentation of pigmented skin lesions: a review

Background and objectives: Because skin cancer affects millions of people worldwide, computational methods for the segmentation of pigmented skin lesions in images have been developed in order to assist dermatologists in their diagnosis. This paper aims to present a review of the current methods, and outline a comparative analysis with regards to several of the fundamental steps of image processing, such as image acquisition, pre-processing and segmentation. Methods: Techniques that have been proposed to achieve these tasks were identified and reviewed. As to the image segmentation task, the techniques were classified according to their principle. Results: The techniques employed in each step are explained, and their strengths and weaknesses are identified. In addition, several of the reviewed techniques are applied to macroscopic and dermoscopy images in order to exemplify their results. Conclusions: The image segmentation of skin lesions has been addressed successfully in many studies; however, there is a demand for new methodologies in order to improve the efficiency

Quantification of structures of skin lesion and calibration of dermoscopy images for automated melanoma diagnosis

研究成果の概要 (和文) : 我々が開発している、インターネット上の悪性黒色腫自動診断支援システムの実用化を具体的に推進するために、課題名にある2点の開発を重点的に行った。(1)定量化研究においては、皮膚科医が臨床現場で用いるABCD rule、7-point checklistの全15項目について、皮膚科医の判断と統計的有意差が見られないモデルの構築に成功した。(2)画像補正研究においては、特殊なハードウェアなどを必要とせず、画像の明度、色彩を適切なダーモスコピー画像のものに調整する手法を確立した。研究成果の概要 (英文) : I had investigated mainly following two themes for making our Internet-based melanoma screening system fit for practical use. (1) Quantification of dermoscopic structures (2) Development of automated color calibration for dermoscopy images. For both themes, I had successfully achieved the objectives set out in the proposal. (1) Succeeded to build a recognition system that has statistically no difference with expert dermatologists in recognizing a total of 15 dermoscopic structures defined in ABCD rule and 7-point checklist. (2) Achieved equivalent color calibration performance for dermoscopy images in luminance, hue and saturation without any special devices

Computer aided diagnosis system using dermatoscopical image

Computer Aided Diagnosis (CAD) systems for melanoma detection aim to mirror the expert dermatologist decision when watching a dermoscopic or clinical image. Computer Vision techniques, which can be based on expert knowledge or not, are used to characterize the lesion image. This information is delivered to a machine learning algorithm, which gives a diagnosis suggestion as an output. This research is included into this field, and addresses the objective of implementing a complete CAD system using ‘state of the art’ descriptors and dermoscopy images as input. Some of them are based on expert knowledge and others are typical in a wide variety of problems. Images are initially transformed into oRGB, a perceptual color space, looking for both enhancing the information that images provide and giving human perception to machine algorithms. Feature selection is also performed to find features that really contribute to discriminate between benign and malignant pigmented skin lesions (PSL). The problem of robust model fitting versus statistically significant system evaluation is critical when working with small datasets, which is indeed the case. This topic is not generally considered in works related to PSLs. Consequently, a method that optimizes the compromise between these two goals is proposed, giving non-overfitted models and statistically significant measures of performance. In this manner, different systems can be compared in a fairer way. A database which enjoys wide international acceptance among dermatologists is used for the experiments.Ingeniería de Sistemas Audiovisuale

Incorporating Colour Information for Computer-Aided Diagnosis of Melanoma from Dermoscopy Images: A Retrospective Survey and Critical Analysis

Cutaneous melanoma is the most life-threatening form of skin cancer. Although advanced melanoma is often considered as incurable, if detected and excised early, the prognosis is promising. Today, clinicians use computer vision in an increasing number of applications to aid early detection of melanoma through dermatological image analysis (dermoscopy images, in particular). Colour assessment is essential for the clinical diagnosis of skin cancers. Due to this diagnostic importance, many studies have either focused on or employed colour features as a constituent part of their skin lesion analysis systems. These studies range from using low-level colour features, such as simple statistical measures of colours occurring in the lesion, to availing themselves of high-level semantic features such as the presence of blue-white veil, globules, or colour variegation in the lesion. This paper provides a retrospective survey and critical analysis of contributions in this research direction

Computational Methods for Pigmented Skin Lesion Classification in Images: Review and Future Trends

Skin cancer is considered as one of the most common types of cancer in several countries, and its incidence rate has increased in recent years. Melanoma cases have caused an increasing number of deaths worldwide, since this type of skin cancer is the most aggressive compared to other types. Computational methods have been developed to assist dermatologists in early diagnosis of skin cancer. An overview of the main and current computational methods that have been proposed for pattern analysis and pigmented skin lesion classification is addressed in this review. In addition, a discussion about the application of such methods, as well as future trends, is also provided. Several methods for feature extraction from both macroscopic and dermoscopic images and models for feature selection are introduced and discussed. Furthermore, classification algorithms and evaluation procedures are described, and performance results for lesion classification and pattern analysis are given

A comparative study of algorithms for automatic segmentation of dermoscopic images

Melanoma is the most common as well as the most dangerous type of skin cancer. Nevertheless, it can be effectively treated if detected early. Dermoscopy is one of the major non-invasive imaging techniques for the diagnosis of skin lesions. The computer-aided diagnosis based on the processing of dermoscopic images aims to reduce the subjectivity and time-consuming analysis related to traditional diagnosis. The first step of automatic diagnosis is image segmentation. In this project, the implementation and evaluation of several methods were proposed for the automatic segmentation of lesion regions in dermoscopic images, along with the corresponding implemented phases for image preprocessing and postprocessing. The developed algorithms include methods based on different state of the art techniques. The main groups of techniques which have been selected to be studied and implemented are thresholding-based methods, region-based methods, segmentation based on deformable models, as well as a new proposed approach based on the bag-of-words model. The implemented methods incorporate modifications for a better adaptation to features associated with dermoscopic images. Each implemented method was applied to a database constituted by 724 dermoscopic images. The output of the automatic segmentation procedure for each image was compared with the corresponding manual segmentation in order to evaluate the performance. The comparison between algorithms was carried out regarding the obtained evaluation metrics. The best results were achieved by the combination of region-based segmentation based on the multi-region adaptation of the k-means algorithm and the subIngeniería de Sistemas Audiovisuale