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Effect of Time-of-Flight and Regularized Reconstructions on Quantitative Measurements and Qualitative Assessments in Newly Diagnosed Prostate Cancer With 18F-Fluorocholine Dual Time Point PET/MRI.
Recent technical advances in positron emission tomography/magnetic resonance imaging (PET/MRI) technology allow much improved time-of-flight (TOF) and regularized iterative PET reconstruction regularized iterative reconstruction (RIR) algorithms. We evaluated the effect of TOF and RIR on standardized uptake values (maximum and peak SUV [SUVmax and SUVpeak]) and their metabolic tumor volume dependencies and visual image quality for 18F-fluorocholine PET/MRI in patients with newly diagnosed prostate cancer. Fourteen patients were administered with 3 MBq/kg of 18F-fluorocholine and scanned dynamically for 30 minutes. Positron emission tomography images were divided to early and late time points (1-6 minutes summed and 7-30 minutes summed). The values of the different SUVs were documented for dominant PET-avid lesions, and metabolic tumor volume was estimated using a 50% isocontour and SUV threshold of 2.5. Image quality was assessed via visual acuity scoring (VAS). We found that incorporation of TOF or RIR increased lesion SUVs. The lesion to background ratio was not improved by TOF reconstruction, while RIR improved the lesion to background ratio significantly ( P < .05). The values of the different VAS were all significantly higher ( P < .05) for RIR images over TOF, RIR over non-TOF, and TOF over non-TOF. In conclusion, our data indicate that TOF or RIR should be incorporated into current protocols when available
Evaluation of Single-Chip, Real-Time Tomographic Data Processing on FPGA - SoC Devices
A novel approach to tomographic data processing has been developed and
evaluated using the Jagiellonian PET (J-PET) scanner as an example. We propose
a system in which there is no need for powerful, local to the scanner
processing facility, capable to reconstruct images on the fly. Instead we
introduce a Field Programmable Gate Array (FPGA) System-on-Chip (SoC) platform
connected directly to data streams coming from the scanner, which can perform
event building, filtering, coincidence search and Region-Of-Response (ROR)
reconstruction by the programmable logic and visualization by the integrated
processors. The platform significantly reduces data volume converting raw data
to a list-mode representation, while generating visualization on the fly.Comment: IEEE Transactions on Medical Imaging, 17 May 201
GATE : a simulation toolkit for PET and SPECT
Monte Carlo simulation is an essential tool in emission tomography that can
assist in the design of new medical imaging devices, the optimization of
acquisition protocols, and the development or assessment of image
reconstruction algorithms and correction techniques. GATE, the Geant4
Application for Tomographic Emission, encapsulates the Geant4 libraries to
achieve a modular, versatile, scripted simulation toolkit adapted to the field
of nuclear medicine. In particular, GATE allows the description of
time-dependent phenomena such as source or detector movement, and source decay
kinetics. This feature makes it possible to simulate time curves under
realistic acquisition conditions and to test dynamic reconstruction algorithms.
A public release of GATE licensed under the GNU Lesser General Public License
can be downloaded at the address http://www-lphe.epfl.ch/GATE/
J-PET Framework: Software platform for PET tomography data reconstruction and analysis
J-PET Framework is an open-source software platform for data analysis,
written in C++ and based on the ROOT package. It provides a common environment
for implementation of reconstruction, calibration and filtering procedures, as
well as for user-level analyses of Positron Emission Tomography data. The
library contains a set of building blocks that can be combined by users with
even little programming experience, into chains of processing tasks through a
convenient, simple and well-documented API. The generic input-output interface
allows processing the data from various sources: low-level data from the
tomography acquisition system or from diagnostic setups such as digital
oscilloscopes, as well as high-level tomography structures e.g. sinograms or a
list of lines-of-response. Moreover, the environment can be interfaced with
Monte Carlo simulation packages such as GEANT and GATE, which are commonly used
in the medical scientific community.Comment: 14 pages, 5 figure
Sub-millimeter nuclear medical imaging with high sensitivity in positron emission tomography using beta-gamma coincidences
We present a nuclear medical imaging technique, employing triple-gamma
trajectory intersections from beta^+ - gamma coincidences, able to reach
sub-millimeter spatial resolution in 3 dimensions with a reduced requirement of
reconstructed intersections per voxel compared to a conventional PET
reconstruction analysis. This '-PET' technique draws on specific beta^+
- decaying isotopes, simultaneously emitting an additional photon. Exploiting
the triple coincidence between the positron annihilation and the third photon,
it is possible to separate the reconstructed 'true' events from background. In
order to characterize this technique, Monte-Carlo simulations and image
reconstructions have been performed. The achievable spatial resolution has been
found to reach ca. 0.4 mm (FWHM) in each direction for the visualization of a
22Na point source. Only 40 intersections are sufficient for a reliable
sub-millimeter image reconstruction of a point source embedded in a scattering
volume of water inside a voxel volume of about 1 mm^3 ('high-resolution mode').
Moreover, starting with an injected activity of 400 MBq for ^76Br, the same
number of only about 40 reconstructed intersections are needed in case of a
larger voxel volume of 2 x 2 x 3~mm^3 ('high-sensitivity mode'). Requiring such
a low number of reconstructed events significantly reduces the required
acquisition time for image reconstruction (in the above case to about 140 s)
and thus may open up the perspective for a quasi real-time imaging.Comment: 17 pages, 5 figutes, 3 table
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