Synthetic Observational Health Data with GANs: from slow adoption to a boom in medical research and ultimately digital twins?

After being collected for patient care, Observational Health Data (OHD) can further benefit patient well-being by sustaining the development of health informatics and medical research. Vast potential is unexploited because of the fiercely private nature of patient-related data and regulations to protect it. Generative Adversarial Networks (GANs) have recently emerged as a groundbreaking way to learn generative models that produce realistic synthetic data. They have revolutionized practices in multiple domains such as self-driving cars, fraud detection, digital twin simulations in industrial sectors, and medical imaging. The digital twin concept could readily apply to modelling and quantifying disease progression. In addition, GANs posses many capabilities relevant to common problems in healthcare: lack of data, class imbalance, rare diseases, and preserving privacy. Unlocking open access to privacy-preserving OHD could be transformative for scientific research. In the midst of COVID-19, the healthcare system is facing unprecedented challenges, many of which of are data related for the reasons stated above. Considering these facts, publications concerning GAN applied to OHD seemed to be severely lacking. To uncover the reasons for this slow adoption, we broadly reviewed the published literature on the subject. Our findings show that the properties of OHD were initially challenging for the existing GAN algorithms (unlike medical imaging, for which state-of-the-art model were directly transferable) and the evaluation synthetic data lacked clear metrics. We find more publications on the subject than expected, starting slowly in 2017, and since then at an increasing rate. The difficulties of OHD remain, and we discuss issues relating to evaluation, consistency, benchmarking, data modelling, and reproducibility.Comment: 31 pages (10 in previous version), not including references and glossary, 51 in total. Inclusion of a large number of recent publications and expansion of the discussion accordingl

A Backend Framework for the Efficient Management of Power System Measurements

Increased adoption and deployment of phasor measurement units (PMU) has provided valuable fine-grained data over the grid. Analysis over these data can provide insight into the health of the grid, thereby improving control over operations. Realizing this data-driven control, however, requires validating, processing and storing massive amounts of PMU data. This paper describes a PMU data management system that supports input from multiple PMU data streams, features an event-detection algorithm, and provides an efficient method for retrieving archival data. The event-detection algorithm rapidly correlates multiple PMU data streams, providing details on events occurring within the power system. The event-detection algorithm feeds into a visualization component, allowing operators to recognize events as they occur. The indexing and data retrieval mechanism facilitates fast access to archived PMU data. Using this method, we achieved over 30x speedup for queries with high selectivity. With the development of these two components, we have developed a system that allows efficient analysis of multiple time-aligned PMU data streams.Comment: Published in Electric Power Systems Research (2016), not available ye

Two Procedures for Robust Monitoring of Probability Distributions of Economic Data Streams induced by Depth Functions

Data streams (streaming data) consist of transiently observed, evolving in time, multidimensional data sequences that challenge our computational and/or inferential capabilities. In this paper we propose user friendly approaches for robust monitoring of selected properties of unconditional and conditional distribution of the stream basing on depth functions. Our proposals are robust to a small fraction of outliers and/or inliers but sensitive to a regime change of the stream at the same time. Their implementations are available in our free R package DepthProc.Comment: Operations Research and Decisions, vol. 25, No. 1, 201