Supporting public participation through interactive

A thesis submitted in partial fulfillment of the requirements for the degree of Doctor in Information Management, specialization in Geographic Information SystemsCitizen participation as a key priority of open cities, gives citizens the chance to influence public decision-making. Effectively engaging broader types of citizens into high participation levels has long been an issue due to various situational and technical constrains. Traditional public participation technologies (e.g. public hearing) usually are blame for low accessibility by the general public. The development of Information Communication Technology brings new methods to engage a broader spectrum of citizens in deeper participation level during urban planning processes. Interactive public displays as a public communication medium, hold some key advantages in comparison to other media. Compared to personal devices, public displays make public spaces into sociable places, where social communication and interaction can be enriched without intentionally or unintentionally excluding some groups’ opinions. Public displays can increase the visibility of public events while it is more flexible and up-to-date regarding showing information. Besides, they can also foster a collective awareness and support group behavioral changes. Moreover, due to the public nature of public displays, they provide broad accessibility to different groups of citizens. Public displays have a great potential in bringing new opportunities to facilitate public participation in an urban planning process. In the light of previous work on public displays, the research goal is to investigate a relatively new form of citizen participation known as Public Display Participation. This participation form refers to the use of public displays for citizen participation in the context of urban planning. The main research question of the thesis is how public displays can be used for facilitating citizen consultation in an urban planning process. First, a systematic literature review is done to get an understanding of the current achievements and gaps of research on public displays for public participation. Second, an elicitation study has been conducted to design end user centered interactions with public displays for citizens’ consulting activities. Finally, we run a usability to evaluate the usability of public displays for citizen consultation and their user experience. The main contributions of this thesis can be summarized as: (1) the identification of key challenges and opportunities for future research in using public displays for public participation in urban contexts; (2) two sets of user-defined gestures for two sets of user-defined phone gestures and hand gestures for performing eleven consulting activities, which are about examining the urban planning designs and giving feedback related to design alternatives, are also identified. (3) a new approach for using public displays for voting and commenting in urban planning, and a multi-level evaluation of a prototypical system implementing the proposed approach. Designers and researchers can use the contributions of this thesis, to create interactive public displays for supporting higher public participat i.e. citizen collaboration and empowerment

Physiology of rodent olfactory bulb interneurons

The sense of olfaction is a central gateway of perceiving and evaluating an animal’s environment filled with volatile chemicals. It affects individual and social behavior in an evaluative way, i.e. by helping to find food sources, warning from dangers like toxins or predators or influencing mating choice. Already the first central station for vertebrate olfactory processing, the olfactory bulb (OB), is astonishingly complex. Its structure features several horizontal layers of signal transformation that includes a large variety of local interneurons (INs). Most of these cells are subject to adult neurogenesis, which rejuvenates and remodels the circuitry throughout life. One of those interneuron subtypes, the granule cell (GC), poses the most numerous cell type of the olfactory bulb. As the major synaptic connection of the bulb, linking different glomerular units, it participates in numerous reported tasks like odor discrimination or memory formation. Many of those capacities are attributable to the function of peculiar spines with long necks and enormous bulbar heads called gemmules. They accommodate pre- and postsynaptic specializations of the reciprocal synapse with mitral cells (MCs) that are topographically and functionally linked and feature many modes of signal integration and transmission. As of yet, the mechanistic underpinnings of activation and neurotransmitter release are not yet resolved in great detail. This gave rise to the first project of this thesis, which focusses on the detailed granule cell gemmule physiology during local glutamatergic activation. With the help of two-photon glutamate uncaging and concomitant calcium imaging, the spine could be selectively stimulated and its physiological dynamics tested. By the use of different pharmacological agents, we could verify the importance of voltage gated sodium channels (Nav) for local signal amplification and the involvement of NMDA and high voltage activated calcium channels (HVACCs) in the calcium elevation during local stimulation, which is important for γ-aminobutyric acid (GABA) release from the spine. The superthreshold depolarizing signal and strong calcium elevation during local input are exclusively restricted to the spine, which affirms the chemical and electrical isolation of gemmules from the rest of the cell. In this study we thereby confirmed the theoretical prediction of active computation within single spines in our system, emphasizing the functional importance of morphological compartmentalization for the cell’s physiology. The second largest population of interneurons in the olfactory bulb is located in the glomerular layer (GL) of the olfactory bulb and subsumes a plethora of different cell types, categorized in terms of molecular characteristics (mostly neurotransmitter), morphology and function. Among those, dopaminergic (DAergic) juxtaglomerular cells (JGCs) form a subpopulation, which the second part of this thesis is focused on. Innervated by the first or second synapse in the olfactory pathway, these cells exert strong influence in very early stages of olfactory signaling. The gating and transformation of inputs locally and very importantly also laterally over large distances originate from several factors. This cell grouping usually expresses two neurotransmitters at the same time, GABA and dopamine (DA), and encompass many different morphologies and synaptic arrangements with other cell types. Utilizing dopamine transporter (DAT) based staining methods in three animal populations differing in age and species, this study revealed a larger diversity of dopaminergic cell types in the glomerular layer. New ‘uniglomerular’ and a ‘clasping’ cell types were discriminated, showing distinct dendritic formations and glomerulus innervations, which was assessed with a new morphometric tool kit. The clasping cell type features dendritic specializations, densely clasping around single cell bodies. These morphological traits occur in higher abundance and complexity specifically among adult animals and could be structures of neurotransmitter output since they show strong calcium influx upon soma depolarization. Comparisons of the three animal populations showed age- and/or species-dependent changes in the subtype composition of dopaminergic JGCs. Concordant with recent research, the inclusion of age-dependent comparisons in bulbar studies turned out to be of great significance

NBS monograph

From Introduction: "This is the third in a planned series of reports involving selective literature reviews of research and development requirements and areas of continuing R & D concern in the computer and information sciences and technologies.

Regularisoitu riippuvuuksien mallintaminen geeniekpressio- ja metabolomiikkadatan välillä metabolian säätelyn tutkimuksessa

Fusing different high-throughput data sources is an effective way to reveal functions of unknown genes, as well as regulatory relationships between biological components such as genes and metabolites. Dependencies between biological components functioning in the different layers of biological regulation can be investigated using canonical correlation analysis (CCA). However, the properties of the high-throughput bioinformatics data induce many challenges to data analysis: the sample size is often insufficient compared to the dimensionality of the data, and the data pose multi-collinearity due to, for example, co-expressed and co-regulated genes. Therefore, a regularized version of classical CCA has been adopted. An alternative way of introducing regularization to statistical models is to perform Bayesian data analysis with suitable priors. In this thesis, the performance of a new variant of Bayesian CCA called gsCCA is compared to a classical ridge regression regularized CCA (rrCCA) in revealing relevant information shared between two high-throughput data sets. The gsCCA produces a partly similar regulatory effect as the classical CCA but, in addition, the gsCCA introduces a new type of regularization to the data covariance matrices. Both CCA methods are applied to gene expression and metabolic concentration measurements obtained from an oxidative-stress tolerant Arabidopsis thaliana ecotype Col-0, and an oxidative stress sensitive mutant rcd1 as time series under ozone exposure and in a control condition. The aim of this work is to reveal new regulatory mechanisms in the oxidative stress signalling in plants. For the both methods, rrCCA and gsCCA, the thesis illustrates their potential to reveal both already known and new regulatory mechanisms in Arabidopsis thaliana oxidative stress signalling.Bioinformatiikassa erityyppisten mittausaineistojen yhdistäminen on tehokas tapa selvittää tuntemattomien geenien toiminnallisuutta sekä säätelyvuorovaikutuksia eri biologisten komponenttien, kuten geenien ja metaboliittien, välillä. Riippuvuuksia eri biologisilla säätelytasoilla toimivien komponenttien välillä voidaan tutkia kanonisella korrelaatioanalyysilla (canonical correlation analysis, CCA). Bioinformatiikan tietoaineistot aiheuttavat kuitenkin monia haasteita data-analyysille: näytteiden määrä on usein riittämätön verrattuna aineiston piirteiden määrään, ja aineisto on multikollineaarista johtuen esim. yhdessä säädellyistä ja ilmentyvistä geeneistä. Tästä syystä usein käytetään regularisoitua versiota kanonisesta korrelaatioanalyysistä aineiston tilastolliseen analysointiin. Vaihtoehto regularisoidulle analyysille on bayesilainen lähestymistapa yhdessä sopivien priorioletuksien kanssa. Tässä diplomityössä tutkitaan ja vertaillaan uuden bayesilaisen CCA:n sekä klassisen harjanneregressio-regularisoidun CCA:n kykyä löytää oleellinen jaettu informaatio kahden bioinformatiikka-tietoaineiston välillä. Uuden bayesilaisen menetelmän nimi on ryhmittäin harva kanoninen korrelaatioanalyysi. Ryhmittäin harva CCA tuottaa samanlaisen regularisointivaikutuksen kuin harjanneregressio-CCA, mutta lisäksi uusi menetelmä regularisoi tietoaineistojen kovarianssimatriiseja uudella tavalla. Molempia CCA-menetelmiä sovelletaan geenien ilmentymisaineistoon ja metaboliittien konsentraatioaineistoon, jotka on mitattu Arabidopsis thaliana:n hapetus-stressiä sietävästä ekotyypistä Col-0 ja hapetus-stressille herkästä rcd1 mutantista aika-sarjana, sekä otsoni-altistuksessa että kontrolliolosuhteissa. Diplomityö havainnollistaa harjanneregressio-CCA:n ja ryhmittäin harvan CCA:n kykyä paljastaa jo tunnettuja ja mahdollisesti uusia säätelymekanismeja geenien ja metabolittien välillä kasvisolujen viestinnässä hapettavan stressin aikana

Physiology of rodent olfactory bulb interneurons

The sense of olfaction is a central gateway of perceiving and evaluating an animal’s environment filled with volatile chemicals. It affects individual and social behavior in an evaluative way, i.e. by helping to find food sources, warning from dangers like toxins or predators or influencing mating choice. Already the first central station for vertebrate olfactory processing, the olfactory bulb (OB), is astonishingly complex. Its structure features several horizontal layers of signal transformation that includes a large variety of local interneurons (INs). Most of these cells are subject to adult neurogenesis, which rejuvenates and remodels the circuitry throughout life. One of those interneuron subtypes, the granule cell (GC), poses the most numerous cell type of the olfactory bulb. As the major synaptic connection of the bulb, linking different glomerular units, it participates in numerous reported tasks like odor discrimination or memory formation. Many of those capacities are attributable to the function of peculiar spines with long necks and enormous bulbar heads called gemmules. They accommodate pre- and postsynaptic specializations of the reciprocal synapse with mitral cells (MCs) that are topographically and functionally linked and feature many modes of signal integration and transmission. As of yet, the mechanistic underpinnings of activation and neurotransmitter release are not yet resolved in great detail. This gave rise to the first project of this thesis, which focusses on the detailed granule cell gemmule physiology during local glutamatergic activation. With the help of two-photon glutamate uncaging and concomitant calcium imaging, the spine could be selectively stimulated and its physiological dynamics tested. By the use of different pharmacological agents, we could verify the importance of voltage gated sodium channels (Nav) for local signal amplification and the involvement of NMDA and high voltage activated calcium channels (HVACCs) in the calcium elevation during local stimulation, which is important for γ-aminobutyric acid (GABA) release from the spine. The superthreshold depolarizing signal and strong calcium elevation during local input are exclusively restricted to the spine, which affirms the chemical and electrical isolation of gemmules from the rest of the cell. In this study we thereby confirmed the theoretical prediction of active computation within single spines in our system, emphasizing the functional importance of morphological compartmentalization for the cell’s physiology. The second largest population of interneurons in the olfactory bulb is located in the glomerular layer (GL) of the olfactory bulb and subsumes a plethora of different cell types, categorized in terms of molecular characteristics (mostly neurotransmitter), morphology and function. Among those, dopaminergic (DAergic) juxtaglomerular cells (JGCs) form a subpopulation, which the second part of this thesis is focused on. Innervated by the first or second synapse in the olfactory pathway, these cells exert strong influence in very early stages of olfactory signaling. The gating and transformation of inputs locally and very importantly also laterally over large distances originate from several factors. This cell grouping usually expresses two neurotransmitters at the same time, GABA and dopamine (DA), and encompass many different morphologies and synaptic arrangements with other cell types. Utilizing dopamine transporter (DAT) based staining methods in three animal populations differing in age and species, this study revealed a larger diversity of dopaminergic cell types in the glomerular layer. New ‘uniglomerular’ and a ‘clasping’ cell types were discriminated, showing distinct dendritic formations and glomerulus innervations, which was assessed with a new morphometric tool kit. The clasping cell type features dendritic specializations, densely clasping around single cell bodies. These morphological traits occur in higher abundance and complexity specifically among adult animals and could be structures of neurotransmitter output since they show strong calcium influx upon soma depolarization. Comparisons of the three animal populations showed age- and/or species-dependent changes in the subtype composition of dopaminergic JGCs. Concordant with recent research, the inclusion of age-dependent comparisons in bulbar studies turned out to be of great significance

Data bases and data base systems related to NASA's aerospace program. A bibliography with indexes

This bibliography lists 1778 reports, articles, and other documents introduced into the NASA scientific and technical information system, 1975 through 1980

Australian innovation system report 2011

Key points Metrics and baseline indicators which track progress against the Government’s innovation priorities and targets – these metrics are presented under four themes: skills and research capacity, business innovation, links and collaboration and public sector and social innovation Features and trends of the Australian innovation system and performance as a whole by comparing Australia’s innovation performance to other OECD countries in areas such as framework conditions for entrepreneurship and innovation, the ways Australian firms innovate, investment in intangible capital, collaboration and skills used and shortages Actions, achievements, and forward plans of various participants in the national innovation system, including governments, public sector researchers, and industry

Portugal SB13: contribution of sustainable building to meet EU 20-20-20 targets

Proceedings of the International Conference Portugal SB13: contribution of sustainable building to meet EU 20-20-20 targetsThe international conference Portugal SB13 is organized by the University of Minho, the Technical University of Lisbon and the Portuguese Chapter of the International Initiative for a Sustainable Built Environment in Guimarães, Portugal, from the 30th of October till the 1st of November 2013. This conference is included in the Sustainable Building Conference Series 2013-2014 (SB13-14) that are being organized all over the world. The event is supported by high prestige partners, such as the International Council for Research and Innovation in Building and Construction (CIB), the United Nations Environment Programme (UNEP), the International Federation of Consulting Engineers (FIDIC) and the International Initiative for a Sustainable Built Environment (iiSBE). Portugal SB13 is focused on the theme â Sustainable Building Contribution to Achieve the European Union 20-20-20 Targetsâ . These targets, known as the â EU 20-20-20â targets, set three key objectives for 2020: - A 20% reduction in EU greenhouse gas emissions from 1990 levels; - Raising the share of EU energy consumption produced from renewable resources to 20%; - A 20% improvement in the EU's energy efficiency. Building sector uses about 40% of global energy, 25% of global water, 40% of global resources and emit approximately 1/3 of the global greenhouse gas emissions (the largest contributor). Residential and commercial buildings consume approximately 60% of the worldâ s electricity. Existing buildings represent significant energy saving opportunities because their performance level is frequently far below the current efficiency potentials. Energy consumption in buildings can be reduced by 30 to 80% using proven and commercially available technologies. Investment in building energy efficiency is accompanied by significant direct and indirect savings, which help offset incremental costs, providing a short return on investment period. Therefore, buildings offer the greatest potential for achieving significant greenhouse gas emission reductions, at least cost, in developed and developing countries. On the other hand, there are many more issues related to the sustainability of the built environment than energy. The building sector is responsible for creating, modifying and improving the living environment of the humanity. Construction and buildings have considerable environmental impacts, consuming a significant proportion of limited resources of the planet including raw material, water, land and, of course, energy. The building sector is estimated to be worth 10% of global GDP (5.5 trillion EUR) and employs 111 million people. In developing countries, new sustainable construction opens enormous opportunities because of the population growth and the increasing prosperity, which stimulate the urbanization and the construction activities representing up to 40% of GDP. Therefore, building sustainably will result in healthier and more productive environments. The sustainability of the built environment, the construction industry and the related activities are a pressing issue facing all stakeholders in order to promote the Sustainable Development. The Portugal SB13 conference topics cover a wide range of up-to-date issues and the contributions received from the delegates reflect critical research and the best available practices in the Sustainable Building field. The issues presented include: - Nearly Zero Energy Buildings - Policies for Sustainable Construction - High Performance Sustainable Building Solutions - Design and Technologies for Energy Efficiency - Innovative Construction Systems - Building Sustainability Assessment Tools - Renovation and Retrofitting - Eco-Efficient Materials and Technologies - Urban Regeneration - Design for Life Cycle and Reuse - LCA of sustainable materials and technologies All the articles selected for presentation at the conference and published in these Proceedings, went through a refereed review process and were evaluated by, at least, two reviewers. The Organizers want to thank all the authors who have contributed with papers for publication in the proceedings and to all reviewers, whose efforts and hard work secured the high quality of all contributions to this conference. A special gratitude is also addressed to Eng. José Amarílio Barbosa and to Eng. Catarina Araújo that coordinated the Secretariat of the Conference. Finally, Portugal SB13 wants to address a special thank to CIB, UNEP, FIDIC and iiSBE for their support and wish great success for all the other SB13 events that are taking place all over the world