The Australian methylamphetamine market: the national picture

The Australian Methylamphetamine Market provide a concise understanding of the nature of organised criminal involvement in the Australian methylamphetamine market. The report consolidates open source information with operational and strategic intelligence to inform the Australian public on what the Australian Crime Commission sees as a significant threat to the Australian community. It is intended for the report to inform the national response to the methylamphetamine problem. Aim This report aims to provide a concise understanding of the nature of organised crime involvement in the Australian methylamphetamine market. The ACC monitors all illicit drug markets through its High Risk and Emerging Drugs Special Operation. Through this work, the ACC has assessed that methylamphetamine poses the greatest threat to the Australian public of all illicit drug types. The ACC’s annual Illicit Drug Data Report provides a detailed and comprehensive statistical picture of the illicit drug threat to Australia and provides an in-depth statistical analysis of the illicit drug market. The Australian Methylamphetamine Market: The National Picture is a complementary intelligence report. This report provides a brief summation of the national picture of the methylamphetamine threat. It explores the international and national dimensions of the methylamphetamine market, outlines the role of organised crime in driving the Australian market, the nature of the market, and the harms associated with methylamphetamine use. It also examines the diversion of precursor chemicals required to produce methylamphetamine in clandestine laboratories. It does this by consolidating open source information with operational and strategic intelligence collected by the ACC and Commonwealth, state and territory law enforcement agencies. The release of this report is designed to: ƒƒ inform the widest possible audience, including those who are not privy to classified law enforcement intelligence ƒƒ generate discussion and dialogue about what can be done to tackle the methylamphetamine problem ƒƒ enable individuals, friends and families to understand the nature of the harms caused by methylamphetamine and influence those around them to minimise harm ƒƒ inform the national response to the methylamphetamine market

The Infectious Disease Ontology in the Age of COVID-19

The Infectious Disease Ontology (IDO) is a suite of interoperable ontology modules that aims to provide coverage of all aspects of the infectious disease domain, including biomedical research, clinical care, and public health. IDO Core is designed to be a disease and pathogen neutral ontology, covering just those types of entities and relations that are relevant to infectious diseases generally. IDO Core is then extended by a collection of ontology modules focusing on specific diseases and pathogens. In this paper we present applications of IDO Core within various areas of infectious disease research, together with an overview of all IDO extension ontologies and the methodology on the basis of which they are built. We also survey recent developments involving IDO, including the creation of IDO Virus; the Coronaviruses Infectious Disease Ontology (CIDO); and an extension of CIDO focused on COVID-19 (IDO-CovID-19).We also discuss how these ontologies might assist in information-driven efforts to deal with the ongoing COVID-19 pandemic, to accelerate data discovery in the early stages of future pandemics, and to promote reproducibility of infectious disease research

Networking the way towards antimicrobial combination therapies

Publicado em "8th International Conference on Practical Applications of Computational Biology & Bioinformatics (PACBB 2014)"The exploration of new antimicrobial combinations is a pressing concern for Clinical Microbiology due to the growing number of resistant strains emerging in healthcare settings and in the general community. Researchers are screening agents with alternative modes of action and interest is rising for the potential of antimicrobial peptides (AMPs). This work presents the first ever network reconstruction of AMP combinations reported in the literature fighting Pseudomonas aeruginosa infections. The network, containing 193 combinations of AMPs with 39 AMPs and 154 traditional antibiotics, is expected to help in the design of new studies, notably by unveiling different mechanisms of action and helping in the prediction of new combinations and synergisms. The challenges faced in the attempted text-mining approaches and other considerations regarding the manual curation of the data are pointed out, reflecting about the future automation of this type of reconstruction as means to widen the scope of analysis

A global review of the expansion of multinational healthcare companies

There are some common patterns of expansion among healthcare multinational companies throughout the world. Many are diversifying away from just delivering healthcare to providing health insurance and other financial infrastructure

Between War and Peace: Humanitarian Assistance in Violent Urban Settings

Cities are fast becoming new territories of violence. The humanitarian consequences of many criminally violent urban settings are comparable to those of more traditional wars, yet despite the intensity of the needs, humanitarian aid to such settings is limited. The way in which humanitarian needs are typically defined, fails to address the problems of these contexts, the suffering they produce and the populations affected. Distinctions between formal armed conflicts, regulated by international humanitarian law, and other violent settings, as well as those between emergency and developmental assistance, can lead to the neglect of populations in distress. It can take a lot of time and effort to access vulnerable communities and implement programmes in urban settings, but experience shows that it is possible to provide humanitarian assistance with a significant focus on the direct and indirect health consequences of violence outside a traditional conflict setting. This paper considers the situation of Port-au-Prince (Haiti), Rio de Janeiro (Brazil) and Guatemala City (Guatemala)

A Comparison of U. S. and European University-Industry Relations in the Life Sciences

We draw on diverse data sets to compare the institutional organization of upstream life science research across the United States and Europe. Understanding cross-national differences in the organization of innovative labor in the life sciences requires attention to the structure and evolution of biomedical networks involving public research organizations (universities, government laboratories, nonprofit research institutes, and research hospitals), science-based biotechnology firms, and multinational pharmaceutical corporations. We use network visualization methods and correspondence analyses to demonstrate that innovative research in biomedicine has its origins in regional clusters in the United States and in European nations. But the scientific and organizational composition of these regions varies in consequential ways. In the United States, public research organizations and small firms conduct R&D across multiple therapeutic areas and stages of the development process. Ties within and across these regions link small firms and diverse public institutions, contributing to the development of a robust national network. In contrast, the European story is one of regional specialization with a less diverse group of public research organizations working in a smaller number of therapeutic areas. European institutes develop local connections to small firms working on similar scientific problems, while cross-national linkages of European regional clusters typically involve large pharmaceutical corporations. We show that the roles of large and small firms differ in the United States and Europe, arguing that the greater heterogeneity of the U. S. system is based on much closer integration of basic science and clinical development

Organised crime and international aid subversion: evidence from Colombia and Afghanistan

Scholarly attempts to explain aid subversion in post-conflict contexts frame the challenge in terms of corrupt practices and transactions disconnected from local power struggles. Also, they assume a distinction between organised crime and the state. This comparative analysis of aid subversion in Colombia and Afghanistan reveals the limits of such an approach. Focusing on relations that anchor organised crime within local political, social and economic processes, we demonstrate that organised crime is dynamic, driven by multiple motives, and endogenous to local power politics. Better understanding of governance arrangements around the organised crime-conflict nexus which enable aid subversion is therefore required

Partisanship in Mexico: Influence of Violence and State Spending

This paper serves to further investigate factors influencing partisanship in Mexican politics with a focus on state spending and drug violence. With state spending, this paper builds on prior literature about political effects of federal social spending (Handelman 1997, Domínguez and Chappell 2004, Díaz-Cayeros 2009) to propose a similar theory regarding state social spending. The proposed panel data model for national elections between 2000 and 2012 finds that for diputados elections, a thousand-peso increase in state spending had a statistically significant influence on party voting – boosting PRI candidates (typically incumbents) by 0.66% and hurting both PAN and PRD candidates by 0.78% and 1.57% respectively. This paper also proposes an alternative theory of state spending whereby the effect comes from a linkage of spending and economic performance. With drug violence, this paper studies the importance of the Mexican Drug War on the Mexican political environment but finds no consistent party impact of instability (modeled with intentional homicide statistics) in national elections from 2000 to 2012. This paper delves into potential explanations for this finding including different effects by election, distrust of political parties, and the perception of little difference between parties. Finally, the paper outlines other responses to instability and drug violence to demonstrate approaches taken by Mexican citizens outside of the ballot box. These alternative strategies include protesting, lobbying, migration, and the rise of private security