Gene Expression and its Discontents: Developmental disorders as dysfunctions of epigenetic cognition

Systems biology presently suffers the same mereological and sufficiency fallacies that haunt neural network models of high order cognition. Shifting perspective from the massively parallel space of gene matrix interactions to the grammar/syntax of the time series of expressed phenotypes using a cognitive paradigm permits import of techniques from statistical physics via the homology between information source uncertainty and free energy density. This produces a broad spectrum of possible statistical models of development and its pathologies in which epigenetic regulation and the effects of embedding environment are analogous to a tunable enzyme catalyst. A cognitive paradigm naturally incorporates memory, leading directly to models of epigenetic inheritance, as affected by environmental exposures, in the largest sense. Understanding gene expression, development, and their dysfunctions will require data analysis tools considerably more sophisticated than the present crop of simplistic models abducted from neural network studies or stochastic chemical reaction theory

Experimental Economics for Philosophers

Recently, game theory and evolutionary game theory - mathematical frameworks from economics and biology designed to model and explain interactive behavior - have proved fruitful tools for philosophers in areas such as ethics, philosophy of language, social epistemology, and political philosophy. This methodological osmosis is part of a trend where philosophers have blurred disciplinary lines to import the best epistemic tools available. In this vein, experimental philosophers have drawn on practices from the social sciences, and especially from psychology, to expand philosophy's grasp on issues from morality to consciousness. We argue that the recent prevalence of formal work on human interaction in philosophy opens the door for new methods in experimental philosophy. In particular, we discuss methods from experimental economics, focusing on a small literature we have been developing investigating signaling and communication in humans. We describe results from a novel experiment showing how environmental structure can shape signaling behavior

Experimental Economics for Philosophers

Recently, game theory and evolutionary game theory - mathematical frameworks from economics and biology designed to model and explain interactive behavior - have proved fruitful tools for philosophers in areas such as ethics, philosophy of language, social epistemology, and political philosophy. This methodological osmosis is part of a trend where philosophers have blurred disciplinary lines to import the best epistemic tools available. In this vein, experimental philosophers have drawn on practices from the social sciences, and especially from psychology, to expand philosophy's grasp on issues from morality to consciousness. We argue that the recent prevalence of formal work on human interaction in philosophy opens the door for new methods in experimental philosophy. In particular, we discuss methods from experimental economics, focusing on a small literature we have been developing investigating signaling and communication in humans. We describe results from a novel experiment showing how environmental structure can shape signaling behavior

Dialogue in Peirce, Lotman, and Bakhtin: A comparative study

Th e notion of dialogue is foundational for both Juri Lotman and Mikhail Bakhtin. It is also central in Charles S. Peirce’s semeiotics and logic. While there are several scholarly comparisons of Bakhtin’s and Lotman’s dialogisms, these have yet to be compared with Peirce’s semeiotic dialogues. Th is article takes tentative steps toward a comparative study of dialogue in Peirce, Lotman, and Bakhtin. Peirce’s understanding of dialogue is explicated, and compared with both Lotman’s as well as Bakhtin’s conceptions. Lotman saw dialogue as the basic meaning-making mechanism in the semio sphere. Th e benefi ts and shortcomings of reconceptualizing the semiosphere on the basis of Peircean and Bakhtinian dialogues are weighed. Th e aim is to explore methodological alternatives in semiotics, not to challenge Lotman’s initial model. It is claimed that the semiosphere qua model operating with Bakhtinian dialogues is narrower in scope than Lotman’s original conception, while the semiosphere qua model operating with Peircean dialogues appears to be broader in scope. It is concluded that the choice between alternative dialogical foundations must be informed by attentiveness to their diff erences, and should be motivated by the researcher’s goals and theoretical commitments