Conformal Prediction: a Unified Review of Theory and New Challenges

In this work we provide a review of basic ideas and novel developments about Conformal Prediction -- an innovative distribution-free, non-parametric forecasting method, based on minimal assumptions -- that is able to yield in a very straightforward way predictions sets that are valid in a statistical sense also in in the finite sample case. The in-depth discussion provided in the paper covers the theoretical underpinnings of Conformal Prediction, and then proceeds to list the more advanced developments and adaptations of the original idea.Comment: arXiv admin note: text overlap with arXiv:0706.3188, arXiv:1604.04173, arXiv:1709.06233, arXiv:1203.5422 by other author

Superconformal constraints for QCD conformal anomalies

Anomalous superconformal Ward identities and commutator algebra in N = 1 super-Yang-Mills theory give rise to constraints between the QCD special conformal anomalies of conformal composite operators. We evaluate the superconformal anomalies that appear in the product of renormalized conformal operators and the trace anomaly in the supersymmetric spinor current and check the constraints at one-loop order. In this way we prove the universality of QCD conformal anomalies, which define the non-diagonal part of the anomalous dimension matrix responsible for scaling violations of exclusive QCD amplitudes at the next-to-leading order.Comment: 30 pages, 2 figures, LaTe

Evolution equations beyond one loop from conformal symmetry

We study implications of exact conformal invariance of scalar quantum field theories at the critical point in non-integer dimensions for the evolution kernels of the light-ray operators in physical (integer) dimensions. We demonstrate that all constraints due the conformal symmetry are encoded in the form of the generators of the collinear sl(2) subgroup. Two of them, S_- and S_0, can be fixed at all loops in terms of the evolution kernel, while the generator of special conformal transformations, S_+, receives nontrivial corrections which can be calculated order by order in perturbation theory. Provided that the generator S_+ is known at the k-1 loop order, one can fix the evolution kernel in physical dimension to the k-loop accuracy up to terms that are invariant with respect to the tree-level generators. The invariant parts can easily be restored from the anomalous dimensions. The method is illustrated on two examples: The O(n)-symmetric phi^4 theory in d=4 to the three-loop accuracy, and the su(n) matrix phi^3 theory in d=6 to the two-loop accuracy. We expect that the same technique can be used in gauge theories e.g. in QCD.Comment: 19 pages, 3 figure

Two-loop conformal generators for leading-twist operators in QCD

QCD evolution equations in minimal subtraction schemes have a hidden symmetry: One can construct three operators that commute with the evolution kernel and form an $SL(2)$ algebra, i.e. they satisfy (exactly) the $SL(2)$ commutation relations. In this paper we find explicit expressions for these operators to two-loop accuracy going over to QCD in non-integer $d=4-2\epsilon$ space-time dimensions at the intermediate stage. In this way conformal symmetry of QCD is restored on quantum level at the specially chosen (critical) value of the coupling, and at the same time the theory is regularized allowing one to use the standard renormalization procedure for the relevant Feynman diagrams. Quantum corrections to conformal generators in $d=4-2\epsilon$ effectively correspond to the conformal symmetry breaking in the physical theory in four dimensions and the $SL(2)$ commutation relations lead to nontrivial constraints on the renormalization group equations for composite operators. This approach is valid to all orders in perturbation theory and the result includes automatically all terms that can be identified as due to a nonvanishing QCD $\beta$-function (in the physical theory in four dimensions). Our result can be used to derive three-loop evolution equations for flavor-nonsinglet quark-antiquark operators including mixing with the operators containing total derivatives. These equations govern, e.g., the scale dependence of generalized hadron parton distributions and light-cone meson distribution amplitudes.Comment: 36 page

Improved large-scale prediction of growth inhibition patterns using the NCI60 cancer cell line panel

International audienceMotivation: Recent large-scale omics initiatives have catalogued the somatic alterations of cancer cell line panels along with their pharmacological response to hundreds of compounds. In this study, we have explored these data to advance computational approaches that enable more effective and targeted use of current and future anticancer therapeutics.Results: We modelled the 50% growth inhibition bioassay end-point (GI50) of 17 142 compounds screened against 59 cancer cell lines from the NCI60 panel (941 831 data-points, matrix 93.08% complete) by integrating the chemical and biological (cell line) information. We determine that the protein, gene transcript and miRNA abundance provide the highest predictive signal when modelling the GI50 endpoint, which significantly outperformed the DNA copy-number variation or exome sequencing data (Tukey’s Honestly Significant Difference, P <0.05). We demonstrate that, within the limits of the data, our approach exhibits the ability to both interpolate and extrapolate compound bioactivities to new cell lines and tissues and, although to a lesser extent, to dissimilar compounds. Moreover, our approach outperforms previous models generated on the GDSC dataset. Finally, we determine that in the cases investigated in more detail, the predicted drug-pathway associations and growth inhibition patterns are mostly consistent with the experimental data, which also suggests the possibility of identifying genomic markers of drug sensitivity for novel compounds on novel cell lines

Conformal constraints for anomalous dimensions of leading twist operators

Leading-twist operators have a remarkable property that their divergence vanishes in a free theory. Recently it was suggested that this property can be used for an alternative technique to calculate anomalous dimensions of leading-twist operators and allows one to gain one order in perturbation theory so that, i.e., two-loop anomalous dimensions can be calculated from one-loop Feynman diagrams, etc. In this work we study feasibility of this program on a toy-model example of the $\varphi^3$ theory in six dimensions. Our conclusion is that this approach is valid, although it does not seem to present considerable technical simplifications as compared to the standard technique. It does provide one, however, with a very nontrivial check of the calculation as the structure of the contributions is very different.Comment: 14 pages, 6 figure

Deeply virtual Compton scattering beyond next-to-leading order: the flavor singlet case

We study radiative corrections to deeply virtual Compton scattering in the kinematics of HERA collider experiments to next--to--leading and next--to--next--to--leading order. In the latter case the radiative corrections are evaluated in a special scheme that allows us to employ the predictive power of conformal symmetry. As observed before, the size of next--to--leading order corrections strongly depends on the gluonic input, as gluons start to contribute at this order. Beyond next--to--leading order we find, in contrast, that the corrections for an input scale of few GeV^2 are small enough to justify the uses of perturbation theory. For $\xi > 5 10^{-3}$ the modification of the scale dependence is also small. However, with decreasing $\xi$ it becomes moderate or even large, in particular for the phase.Comment: 17 pages, 2 figure