355,140 research outputs found

    A manufacturing model to support data-driven applications for design and manufacture

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    This thesis is primarily concerned with conceptual work on the Manufacturing Model. The Manufacturing Model is an information model which describes the manufacturing capability of an enterprise. To achieve general applicability, the model consists of the entities that are relevant and important for any type of manufacturing firm, namely: manufacturing resources (e.g. machines, tools, fixtures, machining cells, operators, etc.), manufacturing processes (e.g. injection moulding, machining processes, etc.) and manufacturing strategies (e.g. how these resources and processes are used and organized). The Manufacturing Model is a four level model based on a de—facto standard (i.e. Factory, Shop, Cell, Station) which represents the functionality of the manufacturing facility of any firm. In the course of the research, the concept of data—driven applications has emerged in response to the need of integrated and flexible computer environments for the support of design and manufacturing activities. These data—driven applications require the use of different information models to capture and represent the company's information and knowledge. One of these information models is the Manufacturing Model. The value of this research work is highlighted by the use of two case studies, one related with the representation of a single machining station, and the other, the representation of a multi-cellular manufacturing facility of a high performance company

    Understanding Science Through Knowledge Organizers: An Introduction

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    We propose, in this paper, a teaching program based on a grammar of scientific language borrowed mostly from the area of knowledge representation in computer science and logic. The paper introduces an operationizable framework for understanding knowledge using knowledge representation (KR) methodology. We start with organizing concepts based on their cognitive function, followed by assigning valid and authentic semantic relations to the concepts. We propose that in science education, students can understand better if they organize their knowledge using the KR principles. The process, we claim, can help them to align their conceptual framework with that of experts which we assume is the goal of science education

    Neural Mechanisms for Information Compression by Multiple Alignment, Unification and Search

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    This article describes how an abstract framework for perception and cognition may be realised in terms of neural mechanisms and neural processing. This framework — called information compression by multiple alignment, unification and search (ICMAUS) — has been developed in previous research as a generalized model of any system for processing information, either natural or artificial. It has a range of applications including the analysis and production of natural language, unsupervised inductive learning, recognition of objects and patterns, probabilistic reasoning, and others. The proposals in this article may be seen as an extension and development of Hebb’s (1949) concept of a ‘cell assembly’. The article describes how the concept of ‘pattern’ in the ICMAUS framework may be mapped onto a version of the cell assembly concept and the way in which neural mechanisms may achieve the effect of ‘multiple alignment’ in the ICMAUS framework. By contrast with the Hebbian concept of a cell assembly, it is proposed here that any one neuron can belong in one assembly and only one assembly. A key feature of present proposals, which is not part of the Hebbian concept, is that any cell assembly may contain ‘references’ or ‘codes’ that serve to identify one or more other cell assemblies. This mechanism allows information to be stored in a compressed form, it provides a robust mechanism by which assemblies may be connected to form hierarchies and other kinds of structure, it means that assemblies can express abstract concepts, and it provides solutions to some of the other problems associated with cell assemblies. Drawing on insights derived from the ICMAUS framework, the article also describes how learning may be achieved with neural mechanisms. This concept of learning is significantly different from the Hebbian concept and appears to provide a better account of what we know about human learning

    Visualisation of the information resources for cell biology

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    Intelligent multimodal interfaces can facilitate scientists in utilising available information resources. Combining scientific visualisations with interactive and intelligent tools can help create a “habitable” information space. Development of such tools remains largely iterative. We discuss an ongoing implementation of intelligent interactive visualisation of information resources in cell biology

    Neurally Implementable Semantic Networks

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    We propose general principles for semantic networks allowing them to be implemented as dynamical neural networks. Major features of our scheme include: (a) the interpretation that each node in a network stands for a bound integration of the meanings of all nodes and external events the node links with; (b) the systematic use of nodes that stand for categories or types, with separate nodes for instances of these types; (c) an implementation of relationships that does not use intrinsically typed links between nodes.Comment: 32 pages, 12 figure

    Representation of probabilistic scientific knowledge

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    This article is available through the Brunel Open Access Publishing Fund. Copyright © 2013 Soldatova et al; licensee BioMed Central Ltd.The theory of probability is widely used in biomedical research for data analysis and modelling. In previous work the probabilities of the research hypotheses have been recorded as experimental metadata. The ontology HELO is designed to support probabilistic reasoning, and provides semantic descriptors for reporting on research that involves operations with probabilities. HELO explicitly links research statements such as hypotheses, models, laws, conclusions, etc. to the associated probabilities of these statements being true. HELO enables the explicit semantic representation and accurate recording of probabilities in hypotheses, as well as the inference methods used to generate and update those hypotheses. We demonstrate the utility of HELO on three worked examples: changes in the probability of the hypothesis that sirtuins regulate human life span; changes in the probability of hypotheses about gene functions in the S. cerevisiae aromatic amino acid pathway; and the use of active learning in drug design (quantitative structure activity relation learning), where a strategy for the selection of compounds with the highest probability of improving on the best known compound was used. HELO is open source and available at https://github.com/larisa-soldatova/HELO.This work was partially supported by grant BB/F008228/1 from the UK Biotechnology & Biological Sciences Research Council, from the European Commission under the FP7 Collaborative Programme, UNICELLSYS, KU Leuven GOA/08/008 and ERC Starting Grant 240186
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