Machine Learning and Integrative Analysis of Biomedical Big Data.

Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues

Distributed Triangle Counting in the Graphulo Matrix Math Library

Triangle counting is a key algorithm for large graph analysis. The Graphulo library provides a framework for implementing graph algorithms on the Apache Accumulo distributed database. In this work we adapt two algorithms for counting triangles, one that uses the adjacency matrix and another that also uses the incidence matrix, to the Graphulo library for server-side processing inside Accumulo. Cloud-based experiments show a similar performance profile for these different approaches on the family of power law Graph500 graphs, for which data skew increasingly bottlenecks. These results motivate the design of skew-aware hybrid algorithms that we propose for future work.Comment: Honorable mention in the 2017 IEEE HPEC's Graph Challeng

Regular and almost universal hashing: an efficient implementation

Random hashing can provide guarantees regarding the performance of data structures such as hash tables---even in an adversarial setting. Many existing families of hash functions are universal: given two data objects, the probability that they have the same hash value is low given that we pick hash functions at random. However, universality fails to ensure that all hash functions are well behaved. We further require regularity: when picking data objects at random they should have a low probability of having the same hash value, for any fixed hash function. We present the efficient implementation of a family of non-cryptographic hash functions (PM+) offering good running times, good memory usage as well as distinguishing theoretical guarantees: almost universality and component-wise regularity. On a variety of platforms, our implementations are comparable to the state of the art in performance. On recent Intel processors, PM+ achieves a speed of 4.7 bytes per cycle for 32-bit outputs and 3.3 bytes per cycle for 64-bit outputs. We review vectorization through SIMD instructions (e.g., AVX2) and optimizations for superscalar execution.Comment: accepted for publication in Software: Practice and Experience in September 201

Disaggregating non-volatile memory for throughput-oriented genomics workloads

Massive exploitation of next-generation sequencing technologies requires dealing with both: huge amounts of data and complex bioinformatics pipelines. Computing architectures have evolved to deal with these problems, enabling approaches that were unfeasible years ago: accelerators and Non-Volatile Memories (NVM) are becoming widely used to enhance the most demanding workloads. However, bioinformatics workloads are usually part of bigger pipelines with different and dynamic needs in terms of resources. The introduction of Software Defined Infrastructures (SDI) for data centers provides roots to dramatically increase the efficiency in the management of infrastructures. SDI enables new ways to structure hardware resources through disaggregation, and provides new hardware composability and sharing mechanisms to deploy workloads in more flexible ways. In this paper we study a state-of-the-art genomics application, SMUFIN, aiming to address the challenges of future HPC facilities.This work is partially supported by the European Research Council (ERC) under the EU Horizon 2020 programme (GA 639595), the Spanish Ministry of Economy, Industry and Competitivity (TIN2015-65316-P) and the Generalitat de Catalunya (2014-SGR-1051).Peer ReviewedPostprint (author's final draft