6,461 research outputs found
Scale Stain: Multi-Resolution Feature Enhancement in Pathology Visualization
Digital whole-slide images of pathological tissue samples have recently
become feasible for use within routine diagnostic practice. These gigapixel
sized images enable pathologists to perform reviews using computer workstations
instead of microscopes. Existing workstations visualize scanned images by
providing a zoomable image space that reproduces the capabilities of the
microscope. This paper presents a novel visualization approach that enables
filtering of the scale-space according to color preference. The visualization
method reveals diagnostically important patterns that are otherwise not
visible. The paper demonstrates how this approach has been implemented into a
fully functional prototype that lets the user navigate the visualization
parameter space in real time. The prototype was evaluated for two common
clinical tasks with eight pathologists in a within-subjects study. The data
reveal that task efficiency increased by 15% using the prototype, with
maintained accuracy. By analyzing behavioral strategies, it was possible to
conclude that efficiency gain was caused by a reduction of the panning needed
to perform systematic search of the images. The prototype system was well
received by the pathologists who did not detect any risks that would hinder use
in clinical routine
Context-based Normalization of Histological Stains using Deep Convolutional Features
While human observers are able to cope with variations in color and
appearance of histological stains, digital pathology algorithms commonly
require a well-normalized setting to achieve peak performance, especially when
a limited amount of labeled data is available. This work provides a fully
automated, end-to-end learning-based setup for normalizing histological stains,
which considers the texture context of the tissue. We introduce Feature Aware
Normalization, which extends the framework of batch normalization in
combination with gating elements from Long Short-Term Memory units for
normalization among different spatial regions of interest. By incorporating a
pretrained deep neural network as a feature extractor steering a pixelwise
processing pipeline, we achieve excellent normalization results and ensure a
consistent representation of color and texture. The evaluation comprises a
comparison of color histogram deviations, structural similarity and measures
the color volume obtained by the different methods.Comment: In: 3rd Workshop on Deep Learning in Medical Image Analysis (DLMIA
2017
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