19,071 research outputs found
Structural identifiability analyses of candidate models for in vitro Pitavastatin hepatic uptake
In this paper a review of the application of four different techniques (a version of the similarity transformation approach for autonomous uncontrolled systems, a non-differential input/output observable normal form approach, the characteristic set differential algebra and a recent algebraic input/output relationship approach) to determine the structural identifiability of certain in vitro nonlinear pharmacokinetic models is provided. The Organic Anion Transporting Polypeptide (OATP) substrate, Pitavastatin, is used as a probe on freshly isolated animal and human hepatocytes. Candidate pharmacokinetic non-linear compartmental models have been derived to characterise the uptake process of Pitavastatin. As a prerequisite to parameter estimation, structural identifiability analyses are performed to establish that all unknown parameters can be identified from the experimental observations available
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Precision Extrusion Deposition of Polycaprolactone/Hydroxyapatite Tissue Scaffolds
Freeform fabrication provides an effective process tool to manufacture advanced tissue scaffolds
with specific designed properties. Our research focuses on using a novel Precision Extrusion
Deposition (PED) process technique to directly fabricate Polycaprolactone (PCL) and composite
PCL/ Hydroxyapatite (HA) tissue scaffolds. The scaffold morphology and the mechanical
properties were evaluated using SEM and mechanical testing. In vitro biological studies were
conducted to investigate the cellular responses of the composite scaffolds. Results and
characterizations demonstrate the viability of the PED process as well as the good mechanical
property, structural integrity, controlled pore size, pore interconnectivity, and the biological
compatibility of the fabricated scaffolds.Mechanical Engineerin
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