Ultrawideband Technology for Medical In-Body Sensor Networks: An Overview of the Human Body as a Propagation Medium, Phantoms, and Approaches for Propagation Analysis

[EN] An in-body sensor network is that in which at least one of the sensors is located inside the human body. Such wireless in-body sensors are used mainly in medical applications, collecting and monitoring important parameters for health and disease treatment. IEEE Standard 802.15.6-2012 for wireless body area networks (WBANs) considers in-body communications in the Medical Implant Communications Service (MICS) band. Nevertheless, high-data-rate communications are not feasible at the MICS band because of its narrow occupied bandwidth. In this framework, ultrawideband (UWB) systems have emerged as a potential solution for in-body highdata-rate communications because of their miniaturization capabilities and low power consumption.This work was supported by the Programa de Ayudas de Investigación y Desarrollo (PAID-01-16) at the Universitat Politècnica de València, Spain; by the Ministerio de Economía y Competitividad, Spain (TEC2014-60258-C2-1-R); and by the European FEDER funds. It was also funded by the European Union’s H2020:MSCA:ITN program for the Wireless In-Body Environ-ment Communication–WiBEC project under grant 675353.Garcia-Pardo, C.; Andreu-Estellés, C.; Fornés Leal, A.; Castelló-Palacios, S.; Pérez-Simbor, S.; Barbi, M.; Vallés Lluch, A.... (2018). Ultrawideband Technology for Medical In-Body Sensor Networks: An Overview of the Human Body as a Propagation Medium, Phantoms, and Approaches for Propagation Analysis. IEEE Antennas and Propagation Magazine. 60(3):19-33. https://doi.org/10.1109/MAP.2018.2818458S193360

Wireless capsule gastrointestinal endoscopy: direction of arrival estimation based localization survey

One of the significant challenges in Capsule Endoscopy (CE) is to precisely determine the pathologies location. The localization process is primarily estimated using the received signal strength from sensors in the capsule system through its movement in the gastrointestinal (GI) tract. Consequently, the wireless capsule endoscope (WCE) system requires improvement to handle the lack of the capsule instantaneous localization information and to solve the relatively low transmission data rate challenges. Furthermore, the association between the capsule’s transmitter position, capsule location, signal reduction and the capsule direction should be assessed. These measurements deliver significant information for the instantaneous capsule localization systems based on TOA (time of arrival) approach, PDOA (phase difference of arrival), RSS (received signal strength), electromagnetic, DOA (direction of arrival) and video tracking approaches are developed to locate the WCE precisely. The current article introduces the acquisition concept of the GI medical images using the endoscopy with a comprehensive description of the endoscopy system components. Capsule localization and tracking are considered to be the most important features of the WCE system, thus the current article emphasizes the most common localization systems generally, highlighting the DOA-based localization systems and discusses the required significant research challenges to be addressed

A review of recent innovations in remote health monitoring

The development of remote health monitoring systems has focused on enhancing healthcare services’ efficiency and quality, particularly in chronic disease management and elderly care. These systems employ a range of sensors and wearable devices to track patients’ health status and offer real-time feedback to healthcare providers. This facilitates prompt interventions and reduces hospitalization rates. The aim of this study is to explore the latest developments in the realm of remote health monitoring systems. In this paper, we explore a wide range of domains, spanning antenna designs, small implantable antennas, on-body wearable solutions, and adaptable detection and imaging systems. Our research also delves into the methodological approaches used in monitoring systems, including the analysis of channel characteristics, advancements in wireless capsule endoscopy, and insightful investigations into sensing and imaging techniques. These advancements hold the potential to improve the accuracy and efficiency of monitoring, ultimately contributing to enhanced health outcomes for patients.Publisher's VersionQ2WOS:001130630400001PMID:3813832

UWB radio channel and diversity characterization for wireless implanted devices

Las redes de área corporal permiten la interconexión de nodos independientes situados dentro o fuera de la superficie corporal o, incluso, alejados de dicha superficie. En cuanto a las comunicaciones intracorporales, el establecimiento de un enlace robusto con una cápsula endoscópica o con un marcapasos, son ejemplos de los avances tecnológicos conseguidos en las últimas décadas. A pesar de estos desarrollos en asistencia sanitaria, los estándares actuales para este tipo de comunicaciones no permiten conexiones inalámbricas de alta velocidad de transmisión, las cuales son comunes en los servicios actuales de telecomunicaciones. Los sistemas UWB han surgido como potencial candidato para las futuras redes de comunicaciones inalámbricas intracorporales. No obstante, el principal obstáculo de la tecnología UWB para aplicaciones intracorporales es la alta atenuación que sufren las señales transmitidas al atravesar los distintos tejidos corporales, que aumenta drásticamente con el aumento de la frecuencia. Por tanto, es importante una caracterización precisa del canal UWB intracorporal a la hora de validar dicha banda como la adecuada para este propósito.Esta tesis se centra en el análisis de la tecnología UWB para posibilitar comunicaciones intracorporales inalámbricas desde un punto de vista experimental. Para conseguir este objetivo, se ha empleado un novedoso sistema de medidas experimental basado en fantomas en diversos escenarios de propagación intracorporal. De esta forma, se pueden comprobar las pérdidas de propagación en el medio así como la diversidad del canal de una forma fiable. Con el fin de validar los valores obtenidos en el laboratorio, se han comparado y analizado con los obtenidos en un experimento in vivo. Por otro lado, se han diseñado y fabricado nuevas antenas UWB candidatas para comunicaciones intracorporales, empleando técnicas existentes y nuevas de miniaturización y optimización. Finalmente, se han usado técnicas basadas en diversidad para mejorar el rendimiento del canal de propagación en dos escenarios intracorporales diferentes.Wireless Body Area Networks allow the interconnection between independent nodes located either inside or over the body skin or further. Regarding in-body communications, establishing a proper link with a capsule endoscope or with a pacemaker are examples of technological advances achieved in the last decades. In spite of these healthcare developments, current standards for these kind of communications do not allow high data rate wireless connections, which are common in the current telecommunication services. UWB systems have emerged as a potential solution for future wireless in-body communications. Nevertheless, the main drawback of UWB for in-body applications is the high attenuation of human body tissues which increases dramatically with the increment of frequency. Hence, an accurate UWB in-body channel characterization is relevant in order validate UWB frequency band as the best candidate for future networks of implantable nodes. This thesis is devoted to test UWB technology for in-body communications from an experimental point of view. To achieve this goal, a novel spatial phantom-based measurement setup is used in several in-body propagation scenarios. Thus, the losses in the propagation medium and the channel diversity are checked in a reliable way. In order to check the values obtained in laboratory, they are compared and discussed with those obtained in an in vivo experiment. On the other hand, new UWB antenna candidates for inbody communications are designed and manufactured by using typical and new miniaturization and antenna optimization techniques for this purpose. Finally, diversity-based techniques are used to improve the performance of the propagation channel in two different in-body scenarios.Les xarxes d'àrea corporal permeten la interconnexió de nodes independents situats, o bé dins, o bé sobre la pell, o inclús allunyats del propi cos. Pel que fa a les comunicacions intracorporals, l'establiment d'un bon enllaç amb una càpsula endoscòpica o amb un marcapassos, són exemples dels avanços tecnològics aconseguits les darreres dècades. A pesar d'aquests desenvolupaments en assistència sanitària, els estàndards actuals per a aquests tipus de comunicacions no permeten connexions sense fil d'alta velocitat de transmissió, que són habituals als serveis actuals de telecomunicacions. Els sistemes UWB han sorgit com una solució potencial per a les futures comunicacions sense fill intracorporals. No obstant, el principal obstacle de la tecnologia UWB per a les aplicacions intracorporals és l'alta atenuació dels teixits del cos humà, que augmenta dràsticament amb l'increment de freqüència. Per tant, és important una caracterització acurada del canal UWB intracorporal a l'hora de validar la banda de freqüència UWB com a la millor candidata per a les futures xarxes de nodes implantats.Aquesta tesi se centra en l'anàlisi de la tecnologia UWB per a comunicacions intracorporals des d'un punt de vista experimental. Per a aconseguir aquest objectiu s'ha emprat un sistema novedós de mesures experimentals, basat en fantomes, en diversos escenaris de propagació intracorporal. D'aquesta manera es poden comprovar les pèrdues de propagació en el medi i la diversitat del canal d'una forma fiable. Per tal d'avaluar els valors obtinguts al laboratori, s'han comparat i analitzat amb aquells obtinguts en un experiment in vivo. Per altra banda, s'han dissenyat i fabricat noves antenes UWB candidates per a comunicacions intracorporals emprant tècniques típiques i noves de miniaturització i optimització d'antenes per a aquest propòsit. Finalment s'han usat tècniques basades en diversitat per a millorar el rendiment del canal de propagació en dos escenaris intracorporals diferents.Andreu Estellés, C. (2018). UWB radio channel and diversity characterization for wireless implanted devices [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/111836TESI

IN-BODY RANGING FOR ULTRA-WIDE BAND WIRELESS CAPSULE ENDOSCOPY USING NEURAL NETWORKS BASED ON PARTICLE SWARM OPTIMIZATION

We consider the problem of accurate in-body ranging for localization of a wireless capsule endoscope utilizing ultra-wide band (UWB) signaling. In this context, we explore the joint use of neural network structures and learning algorithms based on metaheuristics, an example of which is particle swarm optimization (PSO). The contributions of this paper are three-fold. First, we undertake a systematic performance analysis of the PSO technique for UWB-based in-body ranging and propose an improved version of the PSO algorithm. Second, we quantitatively compare the performance of PSO techniques against more traditional learning algorithms, such as Bayesian Regularization, Levenberg-Marquardt and Single Conjugate Gradient. Third, we quantify the impact of activation functions used to define the neural network structure on performance. Our results indicate that PSO-based techniques can outperform traditional techniques by as much as 40%, depending on the activation functions used in the neural network

Conformal antenna-based wireless telemetry system for capsule endoscopy

Capsule endoscopy for imaging the gastrointestinal tract is an innovative tool for carrying out medical diagnosis and therapy. Additional modalities beyond optical imaging would enhance current capabilities at the expense of denser integration, due to the limited space available within the capsule. We therefore need new designs and technologies to increase the smartness of the capsules for a given volume. This thesis presents the design, manufacture and performance characterisation of a helical antenna placed conformally outside an endoscopic capsule, and the characterisation in-silico, in-vitro and in-vivo of the telemetry system in alive and euthanised pigs. This method does not use the internal volume of the capsule, but does use an extra coating to protect the antenna from the surrounding tissue and maintain biocompatibility for safe use inside the human body. The helical antenna, radiating at 433 MHz with a bandwidth of 20 MHz within a muscle-type tissue, presents a low gain and efficiency, which is typical for implantable and ingestible medical devices. Telemetry capsule prototypes were simulated, manufactured and assembled with the necessary internal electronics, including a commercially available transceiver unit. Thermistors were embedded into each capsule shell, to record any temperature increase in the tissue surrounding the antenna during the experiments. A temperature increase of less than 1°C was detected for the tissue surrounding the antenna. The process of coating the biocompatible insulation layer over the full length of the capsule is described in detail. Data transmission programmes were established to send programmed data packets to an external receiver. The prototypes radiated at different power levels ranging from -10 to 10 dBm, and all capsules demonstrated a satisfactory performance at a data rate of 16 kbps during phantom and in-vivo experiments. Data transmission was achieved with low bit-error rates below 10-5. A low signal strength of only -54 dBm still provided effective data transfer, irrespective of the orientation and location of the capsule, and this successfully demonstrated the feasibility of the system

Doppler Characterization in Ultra Wideband BAN Channels During Breathing

[EN] Monitoring the physical parameters from devices inside the body, using ultra wideband (UWB) technology, enables the development of high bandwidth demanding applications in real time. The relative movement of the nodes deployed in the body, due to breathing, can give rise to a frequency shifting effect, increasing the fading level in the propagation channel during transmissions. In this article, therefore, we present a study of the frequency effects on the propagation channel derived from the relative movement between two nodes of a wireless body area network (WBAN), at least one of them placed inside the human body, caused by breathing. The study is performed on the basis of the Doppler spectrum characterization in terms of the shape fitting and frequency spread parameter derivation. Continuous wave (CW) signals have been used to cover the UWB range at four selected frequencies: 3.1, 4.8, 6, and 8.5 GHz, and a liquid phantom has been employed for emulating the dielectric properties of the high water content tissues at the considered UWB frequencies.This work was supported in part by the Ministerio de Economia y Competitividad (MINECO), Spain, under Grant TEC2016-78028-C3-2-P, in part by the European Union's H2020-MSCA-ITN Program by the "mmWave Communications in the Built Environments-WaveComBE" Project, under Grant 766231, and in part by the European FEDER funds.García-Serna, RG.; Garcia-Pardo, C.; Molina-García-Pardo, JM.; Juan Llacer, L.; Cardona Marcet, N. (2020). Doppler Characterization in Ultra Wideband BAN Channels During Breathing. IEEE Transactions on Antennas and Propagation. 68(2):1066-1073. https://doi.org/10.1109/TAP.2019.2951849S1066107368

On Simultaneous Localization and Mapping inside the Human Body (Body-SLAM)

Wireless capsule endoscopy (WCE) offers a patient-friendly, non-invasive and painless investigation of the entire small intestine, where other conventional wired endoscopic instruments can barely reach. As a critical component of the capsule endoscopic examination, physicians need to know the precise position of the endoscopic capsule in order to identify the position of intestinal disease after it is detected by the video source. To define the position of the endoscopic capsule, we need to have a map of inside the human body. However, since the shape of the small intestine is extremely complex and the RF signal propagates differently in the non-homogeneous body tissues, accurate mapping and localization inside small intestine is very challenging. In this dissertation, we present an in-body simultaneous localization and mapping technique (Body-SLAM) to enhance the positioning accuracy of the WCE inside the small intestine and reconstruct the trajectory the capsule has traveled. In this way, the positions of the intestinal diseases can be accurately located on the map of inside human body, therefore, facilitates the following up therapeutic operations. The proposed approach takes advantage of data fusion from two sources that come with the WCE: image sequences captured by the WCE\u27s embedded camera and the RF signal emitted by the capsule. This approach estimates the speed and orientation of the endoscopic capsule by analyzing displacements of feature points between consecutive images. Then, it integrates this motion information with the RF measurements by employing a Kalman filter to smooth the localization results and generate the route that the WCE has traveled. The performance of the proposed motion tracking algorithm is validated using empirical data from the patients and this motion model is later imported into a virtual testbed to test the performance of the alternative Body-SLAM algorithms. Experimental results show that the proposed Body-SLAM technique is able to provide accurate tracking of the WCE with average error of less than 2.3cm

Antenna Designs for Wireless Medical Implants.

Active medical implants are devices that are surgically implanted inside the body. They have been developed to treat a wide range of ailments and many require some form of communications link with the outside world for maintenance and for remote medical diagnostics. Radio links promise a wide range of benefits over the traditional low frequency inductive coupling method. Body tissue is a challenging environment, both for the device and for the radio signal that it transmits. Innovation in medical technology is creating a demand for high bandwidth links, and this in turn is driving the development of implantable antennas. Many factors constrain antenna design choices. These include low signal power levels, minimal space availability and the effect that tissue characteristics have on the antenna’s performance. Most body tissues are highly dissipative and antennas must be specifically designed for a high dielectric environment. A review of spectrum availability indicates that the 401 – 406 MHz and 2.4 GHz bands are suitable for implant links. Multiband antennas were explored in the research, but the design priority focussed on the 401 – 406 MHz band. Custom antenna designs were simulated in software and prototypes were later produced and tested in a range of different materials that closely imitate body tissue. Two final designs were developed. The designs are meander-line variants of an inverted-L antenna. Validation tests confirmed a return loss of 10 to 20 dB in a replicated implant environment. The design process, test results and antenna specifications are described in detail