630 research outputs found
Composite Correlation Quantization for Efficient Multimodal Retrieval
Efficient similarity retrieval from large-scale multimodal database is
pervasive in modern search engines and social networks. To support queries
across content modalities, the system should enable cross-modal correlation and
computation-efficient indexing. While hashing methods have shown great
potential in achieving this goal, current attempts generally fail to learn
isomorphic hash codes in a seamless scheme, that is, they embed multiple
modalities in a continuous isomorphic space and separately threshold embeddings
into binary codes, which incurs substantial loss of retrieval accuracy. In this
paper, we approach seamless multimodal hashing by proposing a novel Composite
Correlation Quantization (CCQ) model. Specifically, CCQ jointly finds
correlation-maximal mappings that transform different modalities into
isomorphic latent space, and learns composite quantizers that convert the
isomorphic latent features into compact binary codes. An optimization framework
is devised to preserve both intra-modal similarity and inter-modal correlation
through minimizing both reconstruction and quantization errors, which can be
trained from both paired and partially paired data in linear time. A
comprehensive set of experiments clearly show the superior effectiveness and
efficiency of CCQ against the state of the art hashing methods for both
unimodal and cross-modal retrieval
Machine Learning and Integrative Analysis of Biomedical Big Data.
Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues
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