Parallelization of dynamic programming recurrences in computational biology

The rapid growth of biosequence databases over the last decade has led to a performance bottleneck in the applications analyzing them. In particular, over the last five years DNA sequencing capacity of next-generation sequencers has been doubling every six months as costs have plummeted. The data produced by these sequencers is overwhelming traditional compute systems. We believe that in the future compute performance, not sequencing, will become the bottleneck in advancing genome science. In this work, we investigate novel computing platforms to accelerate dynamic programming algorithms, which are popular in bioinformatics workloads. We study algorithm-specific hardware architectures that exploit fine-grained parallelism in dynamic programming kernels using field-programmable gate arrays: FPGAs). We advocate a high-level synthesis approach, using the recurrence equation abstraction to represent dynamic programming and polyhedral analysis to exploit parallelism. We suggest a novel technique within the polyhedral model to optimize for throughput by pipelining independent computations on an array. This design technique improves on the state of the art, which builds latency-optimal arrays. We also suggest a method to dynamically switch between a family of designs using FPGA reconfiguration to achieve a significant performance boost. We have used polyhedral methods to parallelize the Nussinov RNA folding algorithm to build a family of accelerators that can trade resources for parallelism and are between 15-130x faster than a modern dual core CPU implementation. A Zuker RNA folding accelerator we built on a single workstation with four Xilinx Virtex 4 FPGAs outperforms 198 3 GHz Intel Core 2 Duo processors. Furthermore, our design running on a single FPGA is an order of magnitude faster than competing implementations on similar-generation FPGAs and graphics processors. Our work is a step toward the goal of automated synthesis of hardware accelerators for dynamic programming algorithms

Some advances in the polyhedral model

Department Head: L. Darrell Whitley.2010 Summer.Includes bibliographical references.The polyhedral model is a mathematical formalism and a framework for the analysis and transformation of regular computations. It provides a unified approach to the optimization of computations from different application domains. It is now gaining wide use in optimizing compilers and automatic parallelization. In its purest form, it is based on a declarative model where computations are specified as equations over domains defined by "polyhedral sets". This dissertation presents two results. First is an analysis and optimization technique that enables us to simplify---reduce the asymptotic complexity---of such equations. The second is an extension of the model to richer domains called Ƶ-Polyhedra. Many equational specifications in the polyhedral model have reductions---application of an associative and commutative operator to collections of values to produce a collection of answers. Moreover, expressions in such equations may also exhibit reuse where intermediate values that are computed or used at different index points are identical. We develop various compiler transformations to automatically exploit this reuse and simplify the computational complexity of the specification. In general, there is an infinite set of applicable simplification transformations. Unfortunately, different choices may result in equivalent specifications with different asymptotic complexity. We present an algorithm for the optimal application of simplification transformations resulting in a final specification with minimum complexity. This dissertation also presents the Ƶ-Polyhedral model, an extension to the polyhedral model to more general sets, thereby providing a transformation framework for a larger set of regular computations. For this, we present a novel representation and interpretation of Ƶ-Polyhedra and prove a number of properties of the family of unions of Ƶ-Polyhedra that are required to extend the polyhedral model. Finally, we present value based dependence analysis and scheduling analysis for specifications in the Ƶ-Polyhedral model. These are direct extensions of the corresponding analyses of specifications in the polyhedral model. One of the benefits of our results in the Ƶ-Polyhedral model is that our abstraction allows the reuse of previously developed tools in the polyhedral model with straightforward pre- and post-processing

Tools for efficient Deep Learning

In the era of Deep Learning (DL), there is a fast-growing demand for building and deploying Deep Neural Networks (DNNs) on various platforms. This thesis proposes five tools to address the challenges for designing DNNs that are efficient in time, in resources and in power consumption. We first present Aegis and SPGC to address the challenges in improving the memory efficiency of DL training and inference. Aegis makes mixed precision training (MPT) stabler by layer-wise gradient scaling. Empirical experiments show that Aegis can improve MPT accuracy by at most 4\%. SPGC focuses on structured pruning: replacing standard convolution with group convolution (GConv) to avoid irregular sparsity. SPGC formulates GConv pruning as a channel permutation problem and proposes a novel heuristic polynomial-time algorithm. Common DNNs pruned by SPGC have maximally 1\% higher accuracy than prior work. This thesis also addresses the challenges lying in the gap between DNN descriptions and executables by Polygeist for software and POLSCA for hardware. Many novel techniques, e.g. statement splitting and memory partitioning, are explored and used to expand polyhedral optimisation. Polygeist can speed up software execution in sequential and parallel by 2.53 and 9.47 times on Polybench/C. POLSCA achieves 1.5 times speedup over hardware designs directly generated from high-level synthesis on Polybench/C. Moreover, this thesis presents Deacon, a framework that generates FPGA-based DNN accelerators of streaming architectures with advanced pipelining techniques to address the challenges from heterogeneous convolution and residual connections. Deacon provides fine-grained pipelining, graph-level optimisation, and heuristic exploration by graph colouring. Compared with prior designs, Deacon shows resource/power consumption efficiency improvement of 1.2x/3.5x for MobileNets and 1.0x/2.8x for SqueezeNets. All these tools are open source, some of which have already gained public engagement. We believe they can make efficient deep learning applications easier to build and deploy.Open Acces

Towards Comprehensive Parametric Code Generation Targeting Graphics Processing Units in Support of Scientific Computation

The most popular multithreaded languages based on the fork-join concurrency model (CIlkPlus, OpenMP) are currently being extended to support other forms of parallelism (vectorization, pipelining and single-instruction-multiple-data (SIMD)). In the SIMD case, the objective is to execute the corresponding code on a many-core device, like a GPGPU, for which the CUDA language is a natural choice. Since the programming concepts of CilkPlus and OpenMP are very different from those of CUDA, it is desirable to automatically generate optimized CUDA-like code from CilkPlus or OpenMP. In this thesis, we propose an accelerator model for annotated C/C++ code together with an implementation that allows the automatic generation of CUDA code. One of the key features of this CUDA code generator is that it supports the generation of CUDA kernel code where program parameters (like number of threads per block) and machine parameters (like shared memory size) are treated as unknown symbols. Hence, these parameters need not to be known at code-generation-time: machine parameters and program parameters can be respectively determined when the generated code is installed on the target machine. In addition, we show how these parametric CUDA programs can be optimized at compile-time in the form of a case discussion, where cases depend on the values of machine parameters (e.g. hardware resource limits) and program parameters (e.g. dimension sizes of thread-blocks). This generation of parametric CUDA kernels requires to deal with non-linear polynomial expressions during the dependence analysis and tiling phase. To achieve these algebraic calculations, we take advantage of techniques from computer algebra, in particular in the RegularChains library of Maple. Various illustrative examples are provided together with performance evaluation

On the synthesis of integral and dynamic recurrences

PhD ThesisSynthesis techniques for regular arrays provide a disciplined and well-founded approach to the design of classes of parallel algorithms. The design process is guided by a methodology which is based upon a formal notation and transformations. The mathematical model underlying synthesis techniques is that of affine Euclidean geometry with embedded lattice spaces. Because of this model, computationally powerful methods are provided as an effective way of engineering regular arrays. However, at present the applicability of such methods is limited to so-called affine problems. The work presented in this thesis aims at widening the applicability of standard synthesis methods to more general classes of problems. The major contributions of this thesis are the characterisation of classes of integral and dynamic problems, and the provision of techniques for their systematic treatment within the framework of established synthesis methods. The basic idea is the transformation of the initial algorithm specification into a specification with data dependencies of increased regularity, so that corresponding regular arrays can be obtained by a direct application of the standard mapping techniques. We will complement the formal development of the techniques with the illustration of a number of case studies from the literature.EPSR